Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808148473> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2808148473 abstract "To investigate the mechanism of pericyte migration through Angiopoietin-2 (Ang-2)/Tie-2 signaling pathway.We divided the rats into 5 groups. Each diabetic rat model groups injected with Tie-2 inhibitor, ERK1/2 inhibitor, Akt/PKB inhibitor, and DMSO intravitreal. Retinal digest preparation was done to examine the retinal vasculature including pericyte: endothelial ratio, and morphology of pericyte migration. Tie-2, ERK1/2 and Akt/PKB phosporylation were analyzed by confocal laser scanning microscopy.There was a correlation between pericyte migration with increasing Ang-2 (P<0.05). Pericyte number reduced by 40% (1:2.4) after 5wk diabetes on diabetic rats. The pericyte: endothelial ratio on group with Tie-2 inhibitor were 1:1.8. The same result shows on group with Akt/PKB inhibition. ERK1/2 inhibitor group shows the best results of pericyte: endothelial ratio (1:1.7). Inhibition on Tie-2 receptor decreased the phosphorylation activity of Tie-2, ERK1/2 and Akt/PKB pathway. ERK1/2 inhibition also decreasing the phosphorylation of Tie-2 and Akt/PKB. But on Akt/PKB inhibition, the phosphorylation of Tie-2 and ERK1/2 were relative the same.Ang-2 has a role for pericyte migration on diabetic rats through Tie-2 receptor, ERK1/2 and Akt/PKB pathways. ERK1/2 is a dominant pathway based on the ability to supress another pathway activity and decreasing pericyte migration on diabetic rats." @default.
- W2808148473 created "2018-06-21" @default.
- W2808148473 creator A5009419543 @default.
- W2808148473 creator A5009518533 @default.
- W2808148473 creator A5024578857 @default.
- W2808148473 creator A5033062233 @default.
- W2808148473 creator A5078959404 @default.
- W2808148473 date "2018-03-18" @default.
- W2808148473 modified "2023-10-16" @default.
- W2808148473 title "Mechanism of retinal pericyte migration through Angiopoietin/Tie-2 signaling pathway on diabetic rats" @default.
- W2808148473 cites W1991587502 @default.
- W2808148473 cites W1992190771 @default.
- W2808148473 cites W2015436684 @default.
- W2808148473 cites W2024907834 @default.
- W2808148473 cites W2063057279 @default.
- W2808148473 cites W2078956094 @default.
- W2808148473 cites W2115390024 @default.
- W2808148473 cites W2129790740 @default.
- W2808148473 cites W2139397108 @default.
- W2808148473 cites W2144776559 @default.
- W2808148473 cites W2154926361 @default.
- W2808148473 cites W2157985193 @default.
- W2808148473 cites W2160870679 @default.
- W2808148473 cites W2164951032 @default.
- W2808148473 cites W2167963794 @default.
- W2808148473 cites W2168746915 @default.
- W2808148473 cites W2169758080 @default.
- W2808148473 cites W2300771249 @default.
- W2808148473 cites W2736594300 @default.
- W2808148473 cites W4235369040 @default.
- W2808148473 doi "https://doi.org/10.18240/ijo.2018.03.05" @default.
- W2808148473 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5861225" @default.
- W2808148473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29600169" @default.
- W2808148473 hasPublicationYear "2018" @default.
- W2808148473 type Work @default.
- W2808148473 sameAs 2808148473 @default.
- W2808148473 citedByCount "5" @default.
- W2808148473 countsByYear W28081484732020 @default.
- W2808148473 countsByYear W28081484732021 @default.
- W2808148473 countsByYear W28081484732022 @default.
- W2808148473 countsByYear W28081484732023 @default.
- W2808148473 crossrefType "journal-article" @default.
- W2808148473 hasAuthorship W2808148473A5009419543 @default.
- W2808148473 hasAuthorship W2808148473A5009518533 @default.
- W2808148473 hasAuthorship W2808148473A5024578857 @default.
- W2808148473 hasAuthorship W2808148473A5033062233 @default.
- W2808148473 hasAuthorship W2808148473A5078959404 @default.
- W2808148473 hasBestOaLocation W28081484731 @default.
- W2808148473 hasConcept C118487528 @default.
- W2808148473 hasConcept C11960822 @default.
- W2808148473 hasConcept C123012128 @default.
- W2808148473 hasConcept C126322002 @default.
- W2808148473 hasConcept C134018914 @default.
- W2808148473 hasConcept C185592680 @default.
- W2808148473 hasConcept C202751555 @default.
- W2808148473 hasConcept C2780427682 @default.
- W2808148473 hasConcept C2780827179 @default.
- W2808148473 hasConcept C55493867 @default.
- W2808148473 hasConcept C62478195 @default.
- W2808148473 hasConcept C71924100 @default.
- W2808148473 hasConcept C75217442 @default.
- W2808148473 hasConcept C86803240 @default.
- W2808148473 hasConcept C95444343 @default.
- W2808148473 hasConceptScore W2808148473C118487528 @default.
- W2808148473 hasConceptScore W2808148473C11960822 @default.
- W2808148473 hasConceptScore W2808148473C123012128 @default.
- W2808148473 hasConceptScore W2808148473C126322002 @default.
- W2808148473 hasConceptScore W2808148473C134018914 @default.
- W2808148473 hasConceptScore W2808148473C185592680 @default.
- W2808148473 hasConceptScore W2808148473C202751555 @default.
- W2808148473 hasConceptScore W2808148473C2780427682 @default.
- W2808148473 hasConceptScore W2808148473C2780827179 @default.
- W2808148473 hasConceptScore W2808148473C55493867 @default.
- W2808148473 hasConceptScore W2808148473C62478195 @default.
- W2808148473 hasConceptScore W2808148473C71924100 @default.
- W2808148473 hasConceptScore W2808148473C75217442 @default.
- W2808148473 hasConceptScore W2808148473C86803240 @default.
- W2808148473 hasConceptScore W2808148473C95444343 @default.
- W2808148473 hasLocation W28081484731 @default.
- W2808148473 hasLocation W28081484732 @default.
- W2808148473 hasLocation W28081484733 @default.
- W2808148473 hasLocation W28081484734 @default.
- W2808148473 hasLocation W28081484735 @default.
- W2808148473 hasOpenAccess W2808148473 @default.
- W2808148473 hasPrimaryLocation W28081484731 @default.
- W2808148473 hasRelatedWork W2045005486 @default.
- W2808148473 hasRelatedWork W2074715999 @default.
- W2808148473 hasRelatedWork W2101634100 @default.
- W2808148473 hasRelatedWork W2121295484 @default.
- W2808148473 hasRelatedWork W2135050229 @default.
- W2808148473 hasRelatedWork W2372589721 @default.
- W2808148473 hasRelatedWork W2537134138 @default.
- W2808148473 hasRelatedWork W2748952813 @default.
- W2808148473 hasRelatedWork W2766589798 @default.
- W2808148473 hasRelatedWork W3194519802 @default.
- W2808148473 isParatext "false" @default.
- W2808148473 isRetracted "false" @default.
- W2808148473 magId "2808148473" @default.
- W2808148473 workType "article" @default.