Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808149145> ?p ?o ?g. }
- W2808149145 endingPage "114" @default.
- W2808149145 startingPage "99" @default.
- W2808149145 abstract "Tributyltin chloride (TBT) is an obesogen associated with various metabolic and reproductive dysfunctions after in utero exposure. However, few studies have evaluated TBT’s obesogenic effect on adult ovaries. In this study, we assessed whether TBT’s obesogenic effects resulted in adult ovarian adipogenesis and other reproductive abnormalities. TBT was administered to adult female Wistar rats, and their reproductive tract morphophysiology was assessed. We further assessed the ovarian mRNA/protein expression of genes that regulate adipogenesis. Rats exposed to TBT displayed abnormal estrous cyclicity, ovarian sex hormone levels, ovarian follicular development and ovarian steroidogenic enzyme regulation. Rats exposed to TBT also demonstrated abnormal ovarian adipogenesis with increased cholesterol levels, lipid accumulation, and PPARγ, C/EBP-β and Lipin-1 expression. A negative correlation between the ovarian PPARγ expression and aromatase expression was observed in the TBT rats. Furthermore, TBT exposure resulted in reproductive tract atrophy, inflammation, oxidative stress and fibrosis. Ovarian dysfunctions also co-occurred with the uterine irregularities. Abnormal ovarian adipogenic markers occurring after TBT exposure may be associated with uterine irregularities. A positive correlation between the ovarian cholesterol levels and uterine inflammation was observed in the TBT rats. These findings suggest that TBT leads to ovarian obesogenic effects directly by abnormal adipogenesis and/or indirectly through adult reproductive tract irregularities." @default.
- W2808149145 created "2018-06-21" @default.
- W2808149145 creator A5000984820 @default.
- W2808149145 creator A5001952415 @default.
- W2808149145 creator A5010448643 @default.
- W2808149145 creator A5023245258 @default.
- W2808149145 creator A5029206728 @default.
- W2808149145 creator A5037207855 @default.
- W2808149145 creator A5042607221 @default.
- W2808149145 creator A5049578725 @default.
- W2808149145 creator A5071474022 @default.
- W2808149145 creator A5083255789 @default.
- W2808149145 creator A5087897548 @default.
- W2808149145 date "2018-10-01" @default.
- W2808149145 modified "2023-09-27" @default.
- W2808149145 title "The obesogen tributyltin induces abnormal ovarian adipogenesis in adult female rats" @default.
- W2808149145 cites W1957710301 @default.
- W2808149145 cites W1964734283 @default.
- W2808149145 cites W1973984331 @default.
- W2808149145 cites W1974548765 @default.
- W2808149145 cites W1979164709 @default.
- W2808149145 cites W1984315343 @default.
- W2808149145 cites W1984720580 @default.
- W2808149145 cites W1985204047 @default.
- W2808149145 cites W1995744007 @default.
- W2808149145 cites W2001542472 @default.
- W2808149145 cites W2002519246 @default.
- W2808149145 cites W2007141580 @default.
- W2808149145 cites W2013435542 @default.
- W2808149145 cites W2018115529 @default.
- W2808149145 cites W2020303667 @default.
- W2808149145 cites W2023704290 @default.
- W2808149145 cites W2027966980 @default.
- W2808149145 cites W2031167314 @default.
- W2808149145 cites W2031727355 @default.
- W2808149145 cites W2033183020 @default.
- W2808149145 cites W2035046157 @default.
- W2808149145 cites W2038914291 @default.
- W2808149145 cites W2044412397 @default.
- W2808149145 cites W2058244668 @default.
- W2808149145 cites W2062005522 @default.
- W2808149145 cites W2065439624 @default.
- W2808149145 cites W2067058980 @default.
- W2808149145 cites W2070907292 @default.
- W2808149145 cites W2072045762 @default.
- W2808149145 cites W2084300141 @default.
- W2808149145 cites W2089142609 @default.
- W2808149145 cites W2093044380 @default.
- W2808149145 cites W2107277218 @default.
- W2808149145 cites W2114589445 @default.
- W2808149145 cites W2117923938 @default.
- W2808149145 cites W2120653485 @default.
- W2808149145 cites W2130736113 @default.
- W2808149145 cites W2133461377 @default.
- W2808149145 cites W2135281871 @default.
- W2808149145 cites W2136138120 @default.
- W2808149145 cites W2138250410 @default.
- W2808149145 cites W2140321480 @default.
- W2808149145 cites W2151574084 @default.
- W2808149145 cites W2151723746 @default.
- W2808149145 cites W2157382661 @default.
- W2808149145 cites W2161437953 @default.
- W2808149145 cites W2163051017 @default.
- W2808149145 cites W2165700542 @default.
- W2808149145 cites W2170888799 @default.
- W2808149145 cites W2171302838 @default.
- W2808149145 cites W2205803035 @default.
- W2808149145 cites W2411363873 @default.
- W2808149145 cites W2501562521 @default.
- W2808149145 cites W2513039295 @default.
- W2808149145 cites W2555920391 @default.
- W2808149145 cites W2585837937 @default.
- W2808149145 cites W2763360114 @default.
- W2808149145 cites W2791450253 @default.
- W2808149145 cites W604210470 @default.
- W2808149145 doi "https://doi.org/10.1016/j.toxlet.2018.06.1068" @default.
- W2808149145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29908848" @default.
- W2808149145 hasPublicationYear "2018" @default.
- W2808149145 type Work @default.
- W2808149145 sameAs 2808149145 @default.
- W2808149145 citedByCount "38" @default.
- W2808149145 countsByYear W28081491452018 @default.
- W2808149145 countsByYear W28081491452019 @default.
- W2808149145 countsByYear W28081491452020 @default.
- W2808149145 countsByYear W28081491452021 @default.
- W2808149145 countsByYear W28081491452022 @default.
- W2808149145 countsByYear W28081491452023 @default.
- W2808149145 crossrefType "journal-article" @default.
- W2808149145 hasAuthorship W2808149145A5000984820 @default.
- W2808149145 hasAuthorship W2808149145A5001952415 @default.
- W2808149145 hasAuthorship W2808149145A5010448643 @default.
- W2808149145 hasAuthorship W2808149145A5023245258 @default.
- W2808149145 hasAuthorship W2808149145A5029206728 @default.
- W2808149145 hasAuthorship W2808149145A5037207855 @default.
- W2808149145 hasAuthorship W2808149145A5042607221 @default.
- W2808149145 hasAuthorship W2808149145A5049578725 @default.
- W2808149145 hasAuthorship W2808149145A5071474022 @default.
- W2808149145 hasAuthorship W2808149145A5083255789 @default.