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• W2808220797 abstract "Summary Aim Substance P ( SP ) causes vasodilation and blood pressure ( BP ) reduction. However, the involvement of tachykinin receptors ( NKR s) within baroreflex afferent pathway in SP ‐mediated BP regulation is largely unknown. Methods Under control and hypertensive condition, NKR s’ expressions were evaluated in nodose ( NG ) and nucleus of tractus solitary ( NTS ) of male, female, and ovariectomized ( OVX ) rats; BP was recorded after microinjection of SP and NKR s agonists into NG ; Baroreceptor sensitivity ( BRS ) was tested as well. Results Immunostaining and immunoblotting data showed that NK 1R and NK 2R were estrogen‐dependently expressed on myelinated and unmyelinated afferents in NG . A functional study showed that BP was reduced dose‐dependently by SP microinjection, which was more dramatic in males and can be mimicked by NK 1R and NK 2R agonists. Notably, further BP elevation and BRS dysfunction were confirmed in desoxycorticosterone acetate ( DOCA )‐salt model in OVX compared with DOCA ‐salt model in intact female rats. Additionally, similar changes in NKR s’ expression in NG were also detected using DOCA ‐salt and SHR . Compared with NG , inversed expression profiles of NKR s were also found in NTS with either gender. Conclusion The estrogen‐dependent NKR s’ expression in baroreflex afferent pathway participates at least partially in sexual‐dimorphic and SP ‐mediated BP regulation under physiological and hypertensive conditions." @default.
• W2808220797 created "2018-06-21" @default.
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• W2808220797 date "2018-06-13" @default.
• W2808220797 modified "2023-10-15" @default.
• W2808220797 title "Direct activation of tachykinin receptors within baroreflex afferent pathway and neurocontrol of blood pressure regulation" @default.
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• W2808220797 doi "https://doi.org/10.1111/cns.12993" @default.
• W2808220797 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6436602" @default.
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