FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808230265> ?p ?o ?g. }

• W2808230265 abstract "Introduction: Obstructive sleep apnea (OSA) is a serious and prevalent medical condition with major consequences for health and safety. Excessive daytime sleepiness (EDS) is a common-but not universal-accompanying symptom. The purpose of this literature analysis is to understand whether the presence/absence of EDS is associated with different physiopathologic, prognostic, and therapeutic outcomes in OSA patients. Methods: Articles in English published in PubMed, Medline, and EMBASE between January 2000 and June 2017, focusing on no-EDS OSA patients, were critically reviewed. Results: A relevant percentage of OSA patients do not complain of EDS. EDS is a significant and independent predictor of incident cardiovascular disease (CVD) and is associated with all-cause mortality and an increased risk of metabolic syndrome and diabetes. Male gender, younger age, high body mass index, are predictors of EDS. The positive effects of nasal continuous positive airway pressure (CPAP) therapy on blood pressure, insulin resistance, fatal and non-fatal CVD, and endothelial dysfunction risk factors have been demonstrated in EDS-OSA patients, but results are inconsistent in no-EDS patients. The most sustainable cause of EDS is nocturnal hypoxemia and alterations of sleep architecture, including sleep fragmentation. These changes are less evident in no-EDS patients that seem less susceptible to the cortical effects of apneas. Conclusions: There is no consensus if we should consider OSA as a single disease with different phenotypes with or without EDS, or if there are different diseases with different genetic/epigenetic determinants, pathogenic mechanisms, prognosis, and treatment.The small number of studies focused on this issue indicates the need for further research in this area. Clinicians must carefully assess the presence or absence of EDS and decide accordingly the treatment. This approach could improve combination therapy targeted to a patient's specific pathology to enhance both efficacy and long-term adherence to OSA treatment and significantly reduce the social, economic, and health negative impact of OSA." @default.
• W2808230265 created "2018-06-21" @default.
• W2808230265 creator A5033462632 @default.
• W2808230265 creator A5051588069 @default.
• W2808230265 creator A5053361771 @default.
• W2808230265 creator A5054885498 @default.
• W2808230265 creator A5069071336 @default.
• W2808230265 creator A5081233977 @default.
• W2808230265 date "2018-06-27" @default.
• W2808230265 modified "2023-10-12" @default.
• W2808230265 title "Obstructive Sleep Apnea With or Without Excessive Daytime Sleepiness: Clinical and Experimental Data-Driven Phenotyping" @default.
• W2808230265 cites W118661420 @default.
• W2808230265 cites W147768144 @default.
• W2808230265 cites W1480531314 @default.
• W2808230265 cites W1490801080 @default.
• W2808230265 cites W1497461844 @default.
• W2808230265 cites W1541031456 @default.
• W2808230265 cites W1545648730 @default.
• W2808230265 cites W1601575358 @default.
• W2808230265 cites W1615367021 @default.
• W2808230265 cites W1790658153 @default.
• W2808230265 cites W182302572 @default.
• W2808230265 cites W1823065994 @default.
• W2808230265 cites W1912676390 @default.
• W2808230265 cites W1960516152 @default.
• W2808230265 cites W1964924469 @default.
• W2808230265 cites W1965068329 @default.
• W2808230265 cites W1965141648 @default.
• W2808230265 cites W1966657660 @default.
• W2808230265 cites W1967506791 @default.
• W2808230265 cites W1970950058 @default.
• W2808230265 cites W1972056446 @default.
• W2808230265 cites W1973241164 @default.
• W2808230265 cites W1974439414 @default.
• W2808230265 cites W1975319022 @default.
• W2808230265 cites W1976241412 @default.
• W2808230265 cites W1979386519 @default.
• W2808230265 cites W1982822410 @default.
• W2808230265 cites W1988499887 @default.
• W2808230265 cites W1994156730 @default.
• W2808230265 cites W1996981326 @default.
• W2808230265 cites W1999422411 @default.
• W2808230265 cites W2005349564 @default.
• W2808230265 cites W2005417791 @default.
• W2808230265 cites W2006654450 @default.
• W2808230265 cites W2006878514 @default.
• W2808230265 cites W2011114870 @default.
• W2808230265 cites W2013333500 @default.
• W2808230265 cites W2013691124 @default.
• W2808230265 cites W2014934423 @default.
• W2808230265 cites W2025317126 @default.
• W2808230265 cites W2026191693 @default.
• W2808230265 cites W2031374244 @default.
• W2808230265 cites W2031552314 @default.
• W2808230265 cites W2031750226 @default.
• W2808230265 cites W2034556696 @default.
• W2808230265 cites W2037793634 @default.
• W2808230265 cites W2045561532 @default.
• W2808230265 cites W2048437465 @default.
• W2808230265 cites W2048468809 @default.
• W2808230265 cites W2050113062 @default.
• W2808230265 cites W2051233403 @default.
• W2808230265 cites W2052543150 @default.
• W2808230265 cites W2058520951 @default.
• W2808230265 cites W2062457313 @default.
• W2808230265 cites W2064921388 @default.
• W2808230265 cites W2067944500 @default.
• W2808230265 cites W2069220162 @default.
• W2808230265 cites W2069340435 @default.
• W2808230265 cites W2074291987 @default.
• W2808230265 cites W2079485496 @default.
• W2808230265 cites W2081496318 @default.
• W2808230265 cites W2082533403 @default.
• W2808230265 cites W2083503000 @default.
• W2808230265 cites W2083789006 @default.
• W2808230265 cites W2083860194 @default.
• W2808230265 cites W2084292135 @default.
• W2808230265 cites W2086926485 @default.
• W2808230265 cites W2089429418 @default.
• W2808230265 cites W2095580030 @default.
• W2808230265 cites W2097515450 @default.
• W2808230265 cites W2097688706 @default.
• W2808230265 cites W2098077186 @default.
• W2808230265 cites W2099407948 @default.
• W2808230265 cites W2102522239 @default.
• W2808230265 cites W2103163472 @default.
• W2808230265 cites W2103548686 @default.
• W2808230265 cites W2103647655 @default.
• W2808230265 cites W2103939721 @default.
• W2808230265 cites W2107258965 @default.
• W2808230265 cites W2108496675 @default.
• W2808230265 cites W2112375249 @default.
• W2808230265 cites W2112861297 @default.
• W2808230265 cites W2113743226 @default.
• W2808230265 cites W2117834225 @default.
• W2808230265 cites W2118255543 @default.
• W2808230265 cites W2119054115 @default.
• W2808230265 cites W2119063805 @default.
• W2808230265 cites W2119213758 @default.
• W2808230265 cites W2119344876 @default.

• next