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• W2808255718 abstract "Abstract The increase in greenhouse gases with high global warming potential such as methane is a matter of concern and requires multifaceted efforts to reduce its emission and increase its mitigation from the environment. Microbes such as methanotrophs can assist in methane mitigation. To understand the metabolic capabilities of methanotrophs, a complete genome-scale metabolic model of an obligate methanotroph, Methylococcus capsulatus str. Bath was reconstructed. The model contains 535 genes, 898 reactions and 784 unique metabolites and is named i MC535. The predictive potential of the model was validated using previously-reported experimental data. The model predicted the Entner-Duodoroff (ED) pathway to be essential for the growth of this bacterium, whereas the Embden-Meyerhof-Parnas (EMP) pathway was found non-essential. The performance of the model was simulated on various carbon and nitrogen sources and found that M. capsulatus can grow on amino acids. The analysis of network topology of the model identified that six amino acids were in the top-ranked metabolic hubs. Using flux balance analysis (FBA), 29% of the metabolic genes were predicted to be essential, and 76 double knockout combinations involving 92 unique genes were predicted to be lethal. In conclusion, we have reconstructed a genome-scale metabolic model of a unique methanotroph Methylococcus capsulatus str. Bath. The model will serve as a knowledge-base for deeper understanding, as a platform for exploring the metabolic potential, and as a tool to engineer this bacterium for methane mitigation and industrial applications." @default.
• W2808255718 created "2018-06-21" @default.
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• W2808255718 date "2018-06-18" @default.
• W2808255718 modified "2023-09-27" @default.
• W2808255718 title "Genome-scale metabolic reconstruction and metabolic versatility of an obligate methanotrophMethylococcus capsulatusstr. Bath" @default.
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• W2808255718 doi "https://doi.org/10.1101/349191" @default.
• W2808255718 hasPublicationYear "2018" @default.
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