Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808271009> ?p ?o ?g. }
- W2808271009 abstract "The junctional complexes that couple cardiomyocytes must transmit the mechanical forces of contraction while maintaining adhesive homeostasis. The adherens junction (AJ) connects the actomyosin networks of neighboring cardiomyocytes and is required for proper heart function. Yet little is known about the molecular composition of the cardiomyocyte AJ or how it is organized to function under mechanical load. Here we define the architecture, dynamics and proteome of the cardiomyocyte AJ. Mouse neonatal cardiomyocytes assemble stable AJs along intercellular contacts with organizational and structural hallmarks similar to mature contacts. We combine quantitative mass spectrometry with proximity labeling to identify the N-cadherin (CDH2) interactome. We define over 350 proteins in this interactome, nearly 200 of which are unique to CDH2 and not part of the E-cadherin (CDH1) interactome. CDH2-specific interactors are comprised primarily of adaptor and adhesion proteins that promote junction specialization. Our results provide novel insight into the cardiomyocyte AJ and provide a proteomic atlas for defining the molecular complexes that regulate cardiomyocyte intercellular adhesion." @default.
- W2808271009 created "2018-06-21" @default.
- W2808271009 creator A5005845448 @default.
- W2808271009 creator A5009053119 @default.
- W2808271009 creator A5013299897 @default.
- W2808271009 creator A5024874881 @default.
- W2808271009 creator A5030792778 @default.
- W2808271009 creator A5041636520 @default.
- W2808271009 creator A5047780776 @default.
- W2808271009 creator A5054783962 @default.
- W2808271009 creator A5075446824 @default.
- W2808271009 creator A5088924932 @default.
- W2808271009 date "2019-01-01" @default.
- W2808271009 modified "2023-10-01" @default.
- W2808271009 title "The N-cadherin interactome in primary cardiomyocytes as defined by quantitative proximity proteomics" @default.
- W2808271009 cites W1493497001 @default.
- W2808271009 cites W1578172800 @default.
- W2808271009 cites W1854528864 @default.
- W2808271009 cites W1970831361 @default.
- W2808271009 cites W1971253408 @default.
- W2808271009 cites W1972076214 @default.
- W2808271009 cites W1972682824 @default.
- W2808271009 cites W1973884972 @default.
- W2808271009 cites W1977007311 @default.
- W2808271009 cites W1981184799 @default.
- W2808271009 cites W1993869558 @default.
- W2808271009 cites W1995736912 @default.
- W2808271009 cites W2004736524 @default.
- W2808271009 cites W2010572700 @default.
- W2808271009 cites W2013394636 @default.
- W2808271009 cites W2015351470 @default.
- W2808271009 cites W2016518204 @default.
- W2808271009 cites W2017716708 @default.
- W2808271009 cites W2023958353 @default.
- W2808271009 cites W2029131812 @default.
- W2808271009 cites W2039870758 @default.
- W2808271009 cites W2046290680 @default.
- W2808271009 cites W2051521992 @default.
- W2808271009 cites W2051983016 @default.
- W2808271009 cites W2055592068 @default.
- W2808271009 cites W2059499722 @default.
- W2808271009 cites W2073660522 @default.
- W2808271009 cites W2076049773 @default.
- W2808271009 cites W2080752012 @default.
- W2808271009 cites W2082933118 @default.
- W2808271009 cites W2083779268 @default.
- W2808271009 cites W2085218980 @default.
- W2808271009 cites W2090147884 @default.
- W2808271009 cites W2091013332 @default.
- W2808271009 cites W2091216980 @default.
- W2808271009 cites W2091634027 @default.
- W2808271009 cites W2092528796 @default.
- W2808271009 cites W2092922521 @default.
- W2808271009 cites W2094647249 @default.
- W2808271009 cites W2100636303 @default.
- W2808271009 cites W2105257979 @default.
- W2808271009 cites W2117933964 @default.
- W2808271009 cites W2118567467 @default.
- W2808271009 cites W2121345187 @default.
- W2808271009 cites W2122742614 @default.
- W2808271009 cites W2122778614 @default.
- W2808271009 cites W2122914905 @default.
- W2808271009 cites W2124067739 @default.
- W2808271009 cites W2128551987 @default.
- W2808271009 cites W2130334101 @default.
- W2808271009 cites W2132772764 @default.
- W2808271009 cites W2132864654 @default.
- W2808271009 cites W2135984195 @default.
- W2808271009 cites W2137898197 @default.
- W2808271009 cites W2138839726 @default.
- W2808271009 cites W2143646667 @default.
- W2808271009 cites W2151256435 @default.
- W2808271009 cites W2151447171 @default.
- W2808271009 cites W2152731523 @default.
- W2808271009 cites W2153975342 @default.
- W2808271009 cites W2154830975 @default.
- W2808271009 cites W2167898988 @default.
- W2808271009 cites W2169865172 @default.
- W2808271009 cites W2171580010 @default.
- W2808271009 cites W2185613772 @default.
- W2808271009 cites W2192249410 @default.
- W2808271009 cites W2220807091 @default.
- W2808271009 cites W2265874208 @default.
- W2808271009 cites W2282483835 @default.
- W2808271009 cites W2304846645 @default.
- W2808271009 cites W2328192806 @default.
- W2808271009 cites W2345668379 @default.
- W2808271009 cites W2346937970 @default.
- W2808271009 cites W2407317828 @default.
- W2808271009 cites W2518735686 @default.
- W2808271009 cites W2544360569 @default.
- W2808271009 cites W2559990974 @default.
- W2808271009 cites W2564588200 @default.
- W2808271009 cites W2570852555 @default.
- W2808271009 cites W2597394755 @default.
- W2808271009 cites W2604534935 @default.
- W2808271009 cites W2612240612 @default.
- W2808271009 cites W2623796068 @default.
- W2808271009 cites W2644618666 @default.
- W2808271009 cites W2786841916 @default.