Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808301714> ?p ?o ?g. }
- W2808301714 endingPage "756" @default.
- W2808301714 startingPage "745" @default.
- W2808301714 abstract "Metastasis is the most important feature of gastric cancer (GC) and the most widely recognized reason for GC-related deaths. Unfortunately, the underlying mechanism behind this metastasis remains unknown. Mounting evidence suggests the dynamic regulatory role of sirtuin2 (SIRT2), a histone deacetylase (HDAC), in cell migration and invasion. The present study aims to evaluate the biological function of SIRT2 in GC and identify the target of SIRT2 as well as evaluate its therapeutic efficacy. We found that SIRT2 was upregulated in GC tissues compared to adjacent normal tissues, and this was correlated with reduced patient survival. Although CCK8 and colony-formation assays showed that SIRT2 overexpression marginally promoted proliferation in GC cell lines, SIRT2 knockdown or treatment with SirReal2 decreased the migration and invasion of GC cells. We demonstrated both in vitro and in vivo that SirReal2 could inhibit the deacetylation activity of SIRT2 and its downstream target PEPCK1, which is related to mitochondrial metabolism and RAS/ERK/JNK/MMP-9 pathway. Taken together, these results demonstrate for the first time that SirReal2 selectively targets SIRT2 and decreases migration as well as invasion in human GC cells. SirReal2 therefore shows promise as a new drug candidate for GC therapy." @default.
- W2808301714 created "2018-06-21" @default.
- W2808301714 creator A5000868352 @default.
- W2808301714 creator A5002459266 @default.
- W2808301714 creator A5022235180 @default.
- W2808301714 creator A5022871374 @default.
- W2808301714 creator A5027664400 @default.
- W2808301714 creator A5032741542 @default.
- W2808301714 creator A5037184723 @default.
- W2808301714 creator A5039728001 @default.
- W2808301714 creator A5045392886 @default.
- W2808301714 creator A5045531895 @default.
- W2808301714 creator A5047932326 @default.
- W2808301714 creator A5073216396 @default.
- W2808301714 creator A5079963427 @default.
- W2808301714 creator A5086005204 @default.
- W2808301714 creator A5086839633 @default.
- W2808301714 creator A5089608755 @default.
- W2808301714 creator A5090702667 @default.
- W2808301714 date "2018-07-01" @default.
- W2808301714 modified "2023-10-16" @default.
- W2808301714 title "SIRT2 Promotes the Migration and Invasion of Gastric Cancer through RAS/ERK/JNK/MMP-9 Pathway by Increasing PEPCK1-Related Metabolism" @default.
- W2808301714 cites W140287985 @default.
- W2808301714 cites W1450659139 @default.
- W2808301714 cites W1501165518 @default.
- W2808301714 cites W1708829112 @default.
- W2808301714 cites W1879352431 @default.
- W2808301714 cites W1939575169 @default.
- W2808301714 cites W1977444445 @default.
- W2808301714 cites W1982330633 @default.
- W2808301714 cites W1995044319 @default.
- W2808301714 cites W2020531899 @default.
- W2808301714 cites W2022136169 @default.
- W2808301714 cites W2024452482 @default.
- W2808301714 cites W2025099161 @default.
- W2808301714 cites W2036181747 @default.
- W2808301714 cites W2038009564 @default.
- W2808301714 cites W2042898532 @default.
- W2808301714 cites W2046178144 @default.
- W2808301714 cites W2062641317 @default.
- W2808301714 cites W2063460322 @default.
- W2808301714 cites W2064921878 @default.
- W2808301714 cites W2065649212 @default.
- W2808301714 cites W2070186254 @default.
- W2808301714 cites W2084194105 @default.
- W2808301714 cites W2085872107 @default.
- W2808301714 cites W2087201991 @default.
- W2808301714 cites W2087714970 @default.
- W2808301714 cites W2089370460 @default.
- W2808301714 cites W2089551665 @default.
- W2808301714 cites W2091104996 @default.
- W2808301714 cites W2107498856 @default.
- W2808301714 cites W2117277612 @default.
- W2808301714 cites W2120608933 @default.
- W2808301714 cites W2126547130 @default.
- W2808301714 cites W2127927539 @default.
- W2808301714 cites W2151305493 @default.
- W2808301714 cites W2168630917 @default.
- W2808301714 cites W2188697507 @default.
- W2808301714 cites W2298294785 @default.
- W2808301714 cites W2309478194 @default.
- W2808301714 cites W2319093261 @default.
- W2808301714 cites W2342953417 @default.
- W2808301714 cites W2405732702 @default.
- W2808301714 cites W2410250962 @default.
- W2808301714 cites W2512323670 @default.
- W2808301714 cites W2568724142 @default.
- W2808301714 cites W2570401594 @default.
- W2808301714 cites W2570987484 @default.
- W2808301714 cites W2571548596 @default.
- W2808301714 cites W2575378666 @default.
- W2808301714 cites W2577222535 @default.
- W2808301714 cites W2735265951 @default.
- W2808301714 cites W2753468713 @default.
- W2808301714 cites W2753929680 @default.
- W2808301714 cites W2917837889 @default.
- W2808301714 cites W4250618045 @default.
- W2808301714 doi "https://doi.org/10.1016/j.neo.2018.03.008" @default.
- W2808301714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6005814" @default.
- W2808301714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29925042" @default.
- W2808301714 hasPublicationYear "2018" @default.
- W2808301714 type Work @default.
- W2808301714 sameAs 2808301714 @default.
- W2808301714 citedByCount "70" @default.
- W2808301714 countsByYear W28083017142019 @default.
- W2808301714 countsByYear W28083017142020 @default.
- W2808301714 countsByYear W28083017142021 @default.
- W2808301714 countsByYear W28083017142022 @default.
- W2808301714 countsByYear W28083017142023 @default.
- W2808301714 crossrefType "journal-article" @default.
- W2808301714 hasAuthorship W2808301714A5000868352 @default.
- W2808301714 hasAuthorship W2808301714A5002459266 @default.
- W2808301714 hasAuthorship W2808301714A5022235180 @default.
- W2808301714 hasAuthorship W2808301714A5022871374 @default.
- W2808301714 hasAuthorship W2808301714A5027664400 @default.
- W2808301714 hasAuthorship W2808301714A5032741542 @default.
- W2808301714 hasAuthorship W2808301714A5037184723 @default.
- W2808301714 hasAuthorship W2808301714A5039728001 @default.