Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808305854> ?p ?o ?g. }
- W2808305854 abstract "S100A8 and S100A9 (also known as MRP8 ang MRP14, respectively) are Ca2+ binding proteins belonging to the S100 family. They often exist in the form of heterodimer, while homodimer exists very little because of the stability. S100A8/A9 is constitutively expressed in neutrophils and monocytes as a Ca2+ sensor, participating in cytoskeleton rearrangement and arachidonic acid metabolism. During inflammation, S100A8/A9 is released actively and exerts a critical role in modulating the inflammatory response by stimulating leukocyte recruitment and inducing cytokine secretion. S100A8/A9 serves as a candidate biomarker for diagnosis and follow-up as well as a predictive indicator of therapeutic responses to inflammation-associated diseases. As blockade of S100A8/A9 activity using small-molecule inhibitors or antibodies improves pathological conditions in murine models, the heterodimer has potential as a therapeutic target. In this review, we provide a comprehensive and detailed overview of the distribution and biological functions of S100A8/A9 and highlight its application as a diagnostic and therapeutic target in inflammation-associated diseases." @default.
- W2808305854 created "2018-06-21" @default.
- W2808305854 creator A5000803050 @default.
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- W2808305854 creator A5072288129 @default.
- W2808305854 creator A5073852332 @default.
- W2808305854 creator A5076637933 @default.
- W2808305854 date "2018-06-11" @default.
- W2808305854 modified "2023-10-17" @default.
- W2808305854 title "S100A8/A9 in Inflammation" @default.
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