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- W2808344299 abstract "目的 了解中华(内蒙古)骨髓库蒙古族人群HLA-A、B、DRB1位点基因多态性的特点.方法 采用PCR-反向序列特异性寡核苷酸探针(PCR-RSSOP)杂交方法对蒙古族志愿者的HLA-A、B、DRB1位点上的等位基因作中低分辨基因分型,计算HLA-A、B、DRB1的基因频率,获取该库蒙古族HLA-Ⅰ、Ⅱ类等位基因多态性分布的初布资料.结果 该库蒙古族志愿者HLA-A位点共检出16种等位基因,基因频率较高的是A*02,A*24和A*11,分别为0.5521,0.2703,0.2278;而A*25,A*69的频率最低,均为0.0039;HLA-B位点检出28种等位基因,基因频率较高的是B*40,B*15和B*13分别为0.2703,0.2162和0.1931,频率较低的是B*45,B*59均为0.0039;DRB1位点检出13种等位基因,基因频率较高的是DRB1*15,DRB1*7,DRB1*12,分别为0.2780,0.2741,0.2162,而DRB1*10的频率最低为0.0348.结论 内蒙古骨髓库族志愿者HLA-DRB1等位基因频率具有内蒙地区蒙古族人群共有的遗传特征,但也有其自身的分布特点." @default.
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- W2808344299 date "2007-01-01" @default.
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- W2808344299 title "Polymorphism of HLA-A、B、DRB1 loci in Mongolian population of the Inner Mongolia Registry of CMDP" @default.
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