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• W2808346089 abstract "ABSTRACT 6S RNA is a small RNA regulator of RNA polymerase (RNAP) that is present broadly throughout the bacterial kingdom. Initial functional studies in Escherichia coli revealed that 6S RNA forms a complex with RNAP resulting in regulation of transcription, and cells lacking 6S RNA have altered survival phenotypes. The last decade has focused on deepening the understanding of several aspects of 6S RNA activity, including (i) addressing questions of how broadly conserved 6S RNAs are in diverse organisms through continued identification and initial characterization of divergent 6S RNAs; (ii) the nature of the 6S RNA-RNAP interaction through examination of variant proteins and mutant RNAs, cross-linking approaches, and ultimately a cryo-electron microscopic structure; (iii) the physiological consequences of 6S RNA function through identification of the 6S RNA regulon and promoter features that determine 6S RNA sensitivity; and (iv) the mechanism and cellular impact of 6S RNA-directed synthesis of product RNAs (i.e., pRNA synthesis). Much has been learned about this unusual RNA, its mechanism of action, and how it is regulated; yet much still remains to be investigated, especially regarding potential differences in behavior of 6S RNAs in diverse bacteria." @default.
• W2808346089 created "2018-06-21" @default.
• W2808346089 creator A5081571293 @default.
• W2808346089 date "2018-06-01" @default.
• W2808346089 modified "2023-10-11" @default.
• W2808346089 title "6S RNA, a Global Regulator of Transcription" @default.
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• W2808346089 doi "https://doi.org/10.1128/microbiolspec.rwr-0019-2018" @default.
• W2808346089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6013841" @default.
• W2808346089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29916345" @default.
• W2808346089 hasPublicationYear "2018" @default.
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