Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808364202> ?p ?o ?g. }
- W2808364202 endingPage "88" @default.
- W2808364202 startingPage "78" @default.
- W2808364202 abstract "Previous gene expression analysis identified a network of coexpressed genes that is associated with β-amyloid neuropathology and cognitive decline in older adults. The current work targeted influential genes in this network with quantitative proteomics to identify potential novel therapeutic targets.Data came from 834 community-based older persons who were followed annually, died, and underwent brain autopsy. Uniform structured postmortem evaluations assessed the burden of β-amyloid and other common age-related neuropathologies. Selected reaction monitoring quantified cortical protein abundance of 12 genes prioritized from a molecular network of aging human brain that is implicated in Alzheimer's dementia. Regression and linear mixed models examined the protein associations with β-amyloid load and other neuropathological indices as well as cognitive decline over multiple years preceding death.Average age at death was 88.6 years. Overall, 349 participants (41.9%) had Alzheimer's dementia at death. A higher level of PLXNB1 abundance was associated with more β-amyloid load (p = 1.0 × 10-7 ) and higher PHFtau tangle density (p = 2.3 × 10-7 ), and the association of PLXNB1 with cognitive decline is mediated by these known Alzheimer's disease pathologies. On the other hand, higher IGFBP5, HSPB2, and AK4 and lower ITPK1 levels were associated with faster cognitive decline, and, unlike PLXNB1, these associations were not fully explained by common neuropathological indices, suggesting novel mechanisms leading to cognitive decline.Using targeted proteomics, this work identified cortical proteins involved in Alzheimer's dementia and begins to dissect two different molecular pathways: one affecting β-amyloid deposition and another affecting resilience without a known pathological footprint. Ann Neurol 2018;83:78-88." @default.
- W2808364202 created "2018-06-21" @default.
- W2808364202 creator A5010734294 @default.
- W2808364202 creator A5014075642 @default.
- W2808364202 creator A5020237298 @default.
- W2808364202 creator A5021329449 @default.
- W2808364202 creator A5022309484 @default.
- W2808364202 creator A5022605809 @default.
- W2808364202 creator A5032834920 @default.
- W2808364202 creator A5035096362 @default.
- W2808364202 creator A5049324919 @default.
- W2808364202 creator A5052125746 @default.
- W2808364202 creator A5058811459 @default.
- W2808364202 creator A5065367298 @default.
- W2808364202 creator A5072516895 @default.
- W2808364202 creator A5074663242 @default.
- W2808364202 creator A5078755929 @default.
- W2808364202 date "2018-07-01" @default.
- W2808364202 modified "2023-10-16" @default.
- W2808364202 title "Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia" @default.
- W2808364202 cites W1569155484 @default.
- W2808364202 cites W1581476053 @default.
- W2808364202 cites W1603717990 @default.
- W2808364202 cites W1823837540 @default.
- W2808364202 cites W182422435 @default.
- W2808364202 cites W1931319403 @default.
- W2808364202 cites W1965206733 @default.
- W2808364202 cites W1976537088 @default.
- W2808364202 cites W1990275186 @default.
- W2808364202 cites W1991705437 @default.
- W2808364202 cites W2018337921 @default.
- W2808364202 cites W2033105784 @default.
- W2808364202 cites W2033848869 @default.
- W2808364202 cites W2033952130 @default.
- W2808364202 cites W2040179346 @default.
- W2808364202 cites W2043488532 @default.
- W2808364202 cites W2051479964 @default.
- W2808364202 cites W2056015216 @default.
- W2808364202 cites W2056499061 @default.
- W2808364202 cites W2063562236 @default.
- W2808364202 cites W2068410038 @default.
- W2808364202 cites W2092592736 @default.
- W2808364202 cites W2096355806 @default.
- W2808364202 cites W2114277576 @default.
- W2808364202 cites W2114525505 @default.
- W2808364202 cites W2116958649 @default.
- W2808364202 cites W2118117906 @default.
- W2808364202 cites W2119109232 @default.
- W2808364202 cites W2119519240 @default.
- W2808364202 cites W2120107265 @default.
- W2808364202 cites W2122935853 @default.
- W2808364202 cites W2124681501 @default.
- W2808364202 cites W2127360394 @default.
- W2808364202 cites W2132740963 @default.
- W2808364202 cites W2134836371 @default.
- W2808364202 cites W2135374418 @default.
- W2808364202 cites W2141091417 @default.
- W2808364202 cites W2148357240 @default.
- W2808364202 cites W2151689101 @default.
- W2808364202 cites W2156220037 @default.
- W2808364202 cites W2287080163 @default.
- W2808364202 cites W2411692521 @default.
- W2808364202 cites W2427948242 @default.
- W2808364202 cites W2599229533 @default.
- W2808364202 cites W2607994886 @default.
- W2808364202 cites W2771599582 @default.
- W2808364202 cites W2804633924 @default.
- W2808364202 cites W4299599928 @default.
- W2808364202 doi "https://doi.org/10.1002/ana.25266" @default.
- W2808364202 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6119500" @default.
- W2808364202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29908079" @default.
- W2808364202 hasPublicationYear "2018" @default.
- W2808364202 type Work @default.
- W2808364202 sameAs 2808364202 @default.
- W2808364202 citedByCount "81" @default.
- W2808364202 countsByYear W28083642022018 @default.
- W2808364202 countsByYear W28083642022019 @default.
- W2808364202 countsByYear W28083642022020 @default.
- W2808364202 countsByYear W28083642022021 @default.
- W2808364202 countsByYear W28083642022022 @default.
- W2808364202 countsByYear W28083642022023 @default.
- W2808364202 crossrefType "journal-article" @default.
- W2808364202 hasAuthorship W2808364202A5010734294 @default.
- W2808364202 hasAuthorship W2808364202A5014075642 @default.
- W2808364202 hasAuthorship W2808364202A5020237298 @default.
- W2808364202 hasAuthorship W2808364202A5021329449 @default.
- W2808364202 hasAuthorship W2808364202A5022309484 @default.
- W2808364202 hasAuthorship W2808364202A5022605809 @default.
- W2808364202 hasAuthorship W2808364202A5032834920 @default.
- W2808364202 hasAuthorship W2808364202A5035096362 @default.
- W2808364202 hasAuthorship W2808364202A5049324919 @default.
- W2808364202 hasAuthorship W2808364202A5052125746 @default.
- W2808364202 hasAuthorship W2808364202A5058811459 @default.
- W2808364202 hasAuthorship W2808364202A5065367298 @default.
- W2808364202 hasAuthorship W2808364202A5072516895 @default.
- W2808364202 hasAuthorship W2808364202A5074663242 @default.
- W2808364202 hasAuthorship W2808364202A5078755929 @default.
- W2808364202 hasBestOaLocation W28083642023 @default.