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• W2808372137 abstract "INTRODUCTION :Liver transplantation is the only definite treatment modality for patients withend-stage liver cirrhosis. A major function of the predictive model is toaccurately assess the probability of mortality within a given time interval, sothat a timely liver transplantation can be performed.The Child score, which was first proposed in the 1960s and then modified asthe Child-Turcotte-Pugh (CTP) score. The selection of predictors andconstruction of the CTP system were empirical, and the system containsparameters that were felt very important to affect the outcome.Although never formally validated as a prognostic tool, the CTP score isuseful to assess the relative risk of mortality in patients with cirrhosis andhas been popular for the past 3 decades. However, a major defect of the CTPsystem is a relatively narrow score range from 5 to 15. While the waiting listof liver transplantation is rapidly growing and patients on the waiting list farout number the cadaveric liver donors, the priority of patients with the sameCTP score awaiting transplantation becomes difficult to judge.A simple first-come, first-served principle was proposed and used in thetransplantation society [1]. However, investigators subsequently found thatpatients with a longer waiting time may actually have a less severe degree ofcirrhosis. It was later demonstrated that waiting time is not a factor thataffects survival and was abandoned as a criterion in organ allocation.Another potential inherent flaw of the CTP system is that it containssubjective variables, including the severity of encephalopathy and ascites,which may be greatly influenced by personal judgment from center to centerduring status interpretation. These drawbacks compromise the fairness oforgan allocation in liver transplantation.AIM :The main aim of this prospective study was to compare the accuracy ofthe Child-Pugh score and the MELD score for the prediction of 3 monthand 6 month survival in cirrhotic patients waiting for liver transplantation.CONCLUSION :The present study highlights the following,• The prognostication based on Child Pugh and MELD scores hadalmost identical discriminative ability for predicting 3Month (0.73 vs.0.73) survival in patients on Transplant Waiting list.• The MELD score was better in predicting 6 month (0.82 vs. 0.73)survival when compared with CTP score.• A cut off point of 8.5 CTP score has been found optimal to predictsensitivity of 73.9% and specificity of 79.5%.• A cut off point of 15.5 for the MELD score has been found optimal topredict Sensitivity of 82.6% and specificity of 78%.In the setting of Liver transplant, the MELD may score better over the CTPscore in determination of priorities for organ allocation." @default.
• W2808372137 created "2018-06-21" @default.
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• W2808372137 date "2010-08-01" @default.
• W2808372137 modified "2023-09-27" @default.
• W2808372137 title "Usefulness of CTP score and MELD score in listing patients for liver transplantation." @default.
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