FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808387375> ?p ?o ?g. }

• W2808387375 abstract "Summary H3K9me3, H3K27me3 and H4K20me1 are epigenetic markers associated with chromatin condensation and transcriptional repression. Previously, we found that migration of melanoma cells is associated with and dependent on global chromatin condensation that includes a global increase in these markers. Taken together with more recent reports by others suggest it is a general signature of migrating cells. Here, to learn about the function of these markers in migrating cells we mapped them by ChIP-seq analysis. This analysis revealed that induction of migration leads to expansion of these markers along the genome and to an increased overlapping between them. Significantly, induction of migration led to a higher increase in H3K9me3 and H4K20me1 signals at repetitive elements than at protein-coding genes, while an opposite pattern was found for H3K27me3. Transcriptome analysis revealed that 182 altered genes following induction of migration, of which 33% are dependent on H3K27me3 for these changes. H3K27me3 was also required to prevent changes in the expression of 501 other genes upon induction of migration. Taken together our results suggest that heterochromatinization in migrating cells is global and not restricted to specific genomic loci and that H3K27me3 is a key component in executing a migration-specific transcriptional plan." @default.
• W2808387375 created "2018-06-21" @default.
• W2808387375 creator A5013774287 @default.
• W2808387375 creator A5022625213 @default.
• W2808387375 creator A5025814998 @default.
• W2808387375 date "2018-06-12" @default.
• W2808387375 modified "2023-10-16" @default.
• W2808387375 title "The heterochromatin landscape in migrating cells and the importance of H3K27me3 for migration-associated transcriptional changes" @default.
• W2808387375 cites W147196794 @default.
• W2808387375 cites W1484972278 @default.
• W2808387375 cites W1496606526 @default.
• W2808387375 cites W1527951107 @default.
• W2808387375 cites W1908700664 @default.
• W2808387375 cites W1973033965 @default.
• W2808387375 cites W1979638914 @default.
• W2808387375 cites W1983545974 @default.
• W2808387375 cites W1986801877 @default.
• W2808387375 cites W1994796444 @default.
• W2808387375 cites W2000877345 @default.
• W2808387375 cites W2014677321 @default.
• W2808387375 cites W2015416439 @default.
• W2808387375 cites W2015989042 @default.
• W2808387375 cites W2017508629 @default.
• W2808387375 cites W2026759417 @default.
• W2808387375 cites W2040909468 @default.
• W2808387375 cites W2047247302 @default.
• W2808387375 cites W2060608189 @default.
• W2808387375 cites W2064297857 @default.
• W2808387375 cites W2065886242 @default.
• W2808387375 cites W2074760925 @default.
• W2808387375 cites W2074934579 @default.
• W2808387375 cites W2079322691 @default.
• W2808387375 cites W2095670827 @default.
• W2808387375 cites W2097065948 @default.
• W2808387375 cites W2100592123 @default.
• W2808387375 cites W2102619694 @default.
• W2808387375 cites W2112401372 @default.
• W2808387375 cites W2114104545 @default.
• W2808387375 cites W2117692326 @default.
• W2808387375 cites W2122557087 @default.
• W2808387375 cites W2134526812 @default.
• W2808387375 cites W2137526110 @default.
• W2808387375 cites W2138879453 @default.
• W2808387375 cites W2141693735 @default.
• W2808387375 cites W2142928043 @default.
• W2808387375 cites W2145869787 @default.
• W2808387375 cites W2146512944 @default.
• W2808387375 cites W2148576723 @default.
• W2808387375 cites W2170037266 @default.
• W2808387375 cites W2170551349 @default.
• W2808387375 cites W2221999476 @default.
• W2808387375 cites W2239579513 @default.
• W2808387375 cites W2289339686 @default.
• W2808387375 cites W2303653884 @default.
• W2808387375 cites W2311649981 @default.
• W2808387375 cites W2341539131 @default.
• W2808387375 cites W2345662304 @default.
• W2808387375 cites W2475056796 @default.
• W2808387375 cites W2558411436 @default.
• W2808387375 cites W2568280021 @default.
• W2808387375 cites W2611799052 @default.
• W2808387375 cites W2618049924 @default.
• W2808387375 cites W2765510117 @default.
• W2808387375 cites W2768013244 @default.
• W2808387375 cites W2784942939 @default.
• W2808387375 cites W2916830745 @default.
• W2808387375 doi "https://doi.org/10.1101/344887" @default.
• W2808387375 hasPublicationYear "2018" @default.
• W2808387375 type Work @default.
• W2808387375 sameAs 2808387375 @default.
• W2808387375 citedByCount "3" @default.
• W2808387375 countsByYear W28083873752018 @default.
• W2808387375 countsByYear W28083873752019 @default.
• W2808387375 countsByYear W28083873752021 @default.
• W2808387375 crossrefType "posted-content" @default.
• W2808387375 hasAuthorship W2808387375A5013774287 @default.
• W2808387375 hasAuthorship W2808387375A5022625213 @default.
• W2808387375 hasAuthorship W2808387375A5025814998 @default.
• W2808387375 hasBestOaLocation W28083873751 @default.
• W2808387375 hasConcept C103435993 @default.
• W2808387375 hasConcept C104317684 @default.
• W2808387375 hasConcept C137738243 @default.
• W2808387375 hasConcept C141231307 @default.
• W2808387375 hasConcept C1491633281 @default.
• W2808387375 hasConcept C150194340 @default.
• W2808387375 hasConcept C162317418 @default.
• W2808387375 hasConcept C41091548 @default.
• W2808387375 hasConcept C54355233 @default.
• W2808387375 hasConcept C83640560 @default.
• W2808387375 hasConcept C86803240 @default.
• W2808387375 hasConcept C95444343 @default.
• W2808387375 hasConceptScore W2808387375C103435993 @default.
• W2808387375 hasConceptScore W2808387375C104317684 @default.
• W2808387375 hasConceptScore W2808387375C137738243 @default.
• W2808387375 hasConceptScore W2808387375C141231307 @default.
• W2808387375 hasConceptScore W2808387375C1491633281 @default.
• W2808387375 hasConceptScore W2808387375C150194340 @default.
• W2808387375 hasConceptScore W2808387375C162317418 @default.
• W2808387375 hasConceptScore W2808387375C41091548 @default.
• W2808387375 hasConceptScore W2808387375C54355233 @default.

• next