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• W2808392803 abstract "Objective. T-lymphocyte apoptosis plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE). However, the underlying regulatory mechanisms of apoptosis in SLE remain unclear. The aim of this study was to explore the role of miR-98 in SLE and its underlying mechanisms. Methods. Western blotting and quantitative reverse transcription PCR (qRT-PCR) were used to analyze miR-98 and Fas expression. Luciferase reporter assays were performed to identify miR-98 targets. To modify miRNA levels, miR-98 mimics and inhibitor were transfected into cells. A lentiviral construct was used to overexpress the level of Fas in SLE CD4+ T cells. Gene and protein expression were determined by qRT-PCR and Western blotting. Apoptosis levels were evaluated by annexin V staining and flow cytometry. Results. Compared to those of healthy donors, miR-98 was downregulated in SLE CD4+ T cells, whereas Fas mRNA and protein expression were upregulated. Upregulation of miR-98 by mimic transfection protected Jurkat cells against Fas-mediated apoptosis at both mRNA and protein levels, while miR-98 inhibitor induced the completely opposite effect. Luciferase reporter assays demonstrated that miR-98 directly targeted Fas mRNA. Further, miR-98 inhibitor induced apoptosis in primary healthy CD4+ T cells through the Fas-caspase axis, while upregulation of miR-98 in SLE CD4+ T cells led to the opposite effect. Conclusion. The current study revealed that downregulation of miR-98 induces apoptosis by modulating the Fas-mediated apoptotic signaling pathway in SLE CD4+ T cells. These results suggest that miR-98 might serve as a potential target for SLE treatment." @default.
• W2808392803 created "2018-06-21" @default.
• W2808392803 creator A5022189337 @default.
• W2808392803 creator A5027876738 @default.
• W2808392803 date "2018-06-15" @default.
• W2808392803 modified "2023-10-18" @default.
• W2808392803 title "Role of MiR-98 and Its Underlying Mechanisms in Systemic Lupus Erythematosus" @default.
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• W2808392803 doi "https://doi.org/10.3899/jrheum.171290" @default.
• W2808392803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29907673" @default.
• W2808392803 hasPublicationYear "2018" @default.
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