FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808422384> ?p ?o ?g. }

• W2808422384 abstract "Assisted reproductive technology (ART) has been associated with low birth weight of fresh embryo transfer (FRESH) derived and increased birth weight of frozen embryo transfer (FET)-derived newborns. Owing to that, we focused on imprinted insulin-like growth factor 2 (IGF2)/H19 locus known to be important for normal growth. This locus is regulated by H19 imprinting control region (ICR) with seven binding sites for the methylation-sensitive zinc finger regulatory protein (CTCF). A polymorphism rs10732516 G/A in the sixth binding site for CTCF, associates with a genotype-specific trend to the DNA methylation. Due to this association, 62 couples with singleton pregnancies derived from FRESH (44 IVF/18 ICSI), 24 couples from FET (15 IVF/9 ICSI), and 157 couples with spontaneously conceived pregnancies as controls were recruited in Finland and Estonia for genotype-specific examination. DNA methylation levels at the H19 ICR, H19 DMR, and long interspersed nuclear elements in placental tissue were explored by MassARRAY EpiTYPER (n = 122). Allele-specific changes in the methylation level of H19 ICR in placental tissue (n = 26) and white blood cells (WBC, n = 8) were examined by bisulfite sequencing. Newborns' (n = 243) anthropometrics was analyzed by using international growth standards.A consistent trend of genotype-specific decreased methylation level was observed in paternal allele of rs10732516 paternal A/maternal G genotype, but not in paternal G/maternal A genotype, at H19 ICR in ART placentas. This hypomethylation was not detected in WBCs. Also genotype-specific differences in FRESH-derived newborns' birth weight and head circumference were observed (P = 0.04, P = 0.004, respectively): FRESH-derived newborns with G/G genotype were heavier (P = 0.04) and had larger head circumference (P = 0.002) compared to newborns with A/A genotype. Also, the placental weight and birth weight of controls, FRESH- and FET-derived newborns differed significantly in rs10732516 A/A genotype (P = 0.024, P = 0.006, respectively): the placentas and newborns of FET-derived pregnancies were heavier compared to FRESH-derived pregnancies (P = 0.02, P = 0.004, respectively).The observed DNA methylation changes together with the phenotypic findings suggest that rs10732516 polymorphism associates with the effects of ART in a parent-of-origin manner. Therefore, this polymorphism should be considered when the effects of environmental factors on embryonic development are studied." @default.
• W2808422384 created "2018-06-21" @default.
• W2808422384 creator A5010788057 @default.
• W2808422384 creator A5011453777 @default.
• W2808422384 creator A5011696993 @default.
• W2808422384 creator A5037656140 @default.
• W2808422384 creator A5038905495 @default.
• W2808422384 creator A5046217435 @default.
• W2808422384 creator A5052590660 @default.
• W2808422384 creator A5052683253 @default.
• W2808422384 creator A5061962903 @default.
• W2808422384 creator A5068579328 @default.
• W2808422384 creator A5069397777 @default.
• W2808422384 creator A5072796053 @default.
• W2808422384 creator A5077598674 @default.
• W2808422384 date "2018-06-18" @default.
• W2808422384 modified "2023-10-12" @default.
• W2808422384 title "rs10732516 polymorphism at the IGF2/H19 locus associates with genotype-specific effects on placental DNA methylation and birth weight of newborns conceived by assisted reproductive technology" @default.
• W2808422384 cites W1643500256 @default.
• W2808422384 cites W1821797507 @default.
• W2808422384 cites W1975552240 @default.
• W2808422384 cites W1981371297 @default.
• W2808422384 cites W1992541066 @default.
• W2808422384 cites W2013844122 @default.
• W2808422384 cites W2041490610 @default.
• W2808422384 cites W2063091345 @default.
• W2808422384 cites W2071675221 @default.
• W2808422384 cites W2075744925 @default.
• W2808422384 cites W2078526277 @default.
• W2808422384 cites W2099721980 @default.
• W2808422384 cites W2104549677 @default.
• W2808422384 cites W2105952005 @default.
• W2808422384 cites W2106423392 @default.
• W2808422384 cites W2109580184 @default.
• W2808422384 cites W2113902103 @default.
• W2808422384 cites W2116391993 @default.
• W2808422384 cites W2125404332 @default.
• W2808422384 cites W2127905342 @default.
• W2808422384 cites W2140535499 @default.
• W2808422384 cites W2147038326 @default.
• W2808422384 cites W2149974028 @default.
• W2808422384 cites W2150310487 @default.
• W2808422384 cites W2152137902 @default.
• W2808422384 cites W2152466864 @default.
• W2808422384 cites W2153563181 @default.
• W2808422384 cites W2161584400 @default.
• W2808422384 cites W2163035954 @default.
• W2808422384 cites W2165779364 @default.
• W2808422384 cites W2293253825 @default.
• W2808422384 cites W2558364145 @default.
• W2808422384 cites W2587150222 @default.
• W2808422384 cites W2599208506 @default.
• W2808422384 cites W2610903912 @default.
• W2808422384 cites W2761995490 @default.
• W2808422384 cites W2762249545 @default.
• W2808422384 cites W2767697489 @default.
• W2808422384 cites W2768946593 @default.
• W2808422384 doi "https://doi.org/10.1186/s13148-018-0511-2" @default.
• W2808422384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6006593" @default.
• W2808422384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29946374" @default.
• W2808422384 hasPublicationYear "2018" @default.
• W2808422384 type Work @default.
• W2808422384 sameAs 2808422384 @default.
• W2808422384 citedByCount "24" @default.
• W2808422384 countsByYear W28084223842018 @default.
• W2808422384 countsByYear W28084223842019 @default.
• W2808422384 countsByYear W28084223842020 @default.
• W2808422384 countsByYear W28084223842021 @default.
• W2808422384 countsByYear W28084223842022 @default.
• W2808422384 countsByYear W28084223842023 @default.
• W2808422384 crossrefType "journal-article" @default.
• W2808422384 hasAuthorship W2808422384A5010788057 @default.
• W2808422384 hasAuthorship W2808422384A5011453777 @default.
• W2808422384 hasAuthorship W2808422384A5011696993 @default.
• W2808422384 hasAuthorship W2808422384A5037656140 @default.
• W2808422384 hasAuthorship W2808422384A5038905495 @default.
• W2808422384 hasAuthorship W2808422384A5046217435 @default.
• W2808422384 hasAuthorship W2808422384A5052590660 @default.
• W2808422384 hasAuthorship W2808422384A5052683253 @default.
• W2808422384 hasAuthorship W2808422384A5061962903 @default.
• W2808422384 hasAuthorship W2808422384A5068579328 @default.
• W2808422384 hasAuthorship W2808422384A5069397777 @default.
• W2808422384 hasAuthorship W2808422384A5072796053 @default.
• W2808422384 hasAuthorship W2808422384A5077598674 @default.
• W2808422384 hasBestOaLocation W28084223841 @default.
• W2808422384 hasConcept C104317684 @default.
• W2808422384 hasConcept C111936080 @default.
• W2808422384 hasConcept C135763542 @default.
• W2808422384 hasConcept C150194340 @default.
• W2808422384 hasConcept C160099875 @default.
• W2808422384 hasConcept C16685009 @default.
• W2808422384 hasConcept C180754005 @default.
• W2808422384 hasConcept C189235521 @default.
• W2808422384 hasConcept C190727270 @default.
• W2808422384 hasConcept C196843134 @default.
• W2808422384 hasConcept C201492766 @default.
• W2808422384 hasConcept C2778760011 @default.
• W2808422384 hasConcept C2779234561 @default.
• W2808422384 hasConcept C2994278967 @default.
• W2808422384 hasConcept C33288867 @default.

• next