Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808471142> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2808471142 abstract "Background: The relationship between HPV infections and disease of the human uterine cervix is well established, ranging from CIN (cervical intra-epithelial neoplasia) to SCC (squamous cell carcinoma). Several studies showed correlation between papillomavirus life cycle and differentiation program of infected host cell, in order to produce mature virions in squamous, differentiated cells. The majority of cervical HPV infections are transient. By contrast, persistent HPV infections are much more likely to progress to premalignant and malignant cervical lesions than transient productive infections. Under these conditions, it is believed that viral persistence only occurs upon targeted infections of specific cervical cells such as stem cells. Extension of stem cells theory to solid tumor offers support for new hypothesis in tumorigenesis.Objectives: In order to understand the mechanism that governs balance between epithelial regeneration and transformation we investigated p63 expression, a tumor-suppressive protein considered a marker of keratinocyte stem cell.Materials and Methods: p63 expression was evaluated in immunohistochemistry and RT-PCR using HOPE-fixed, paraffin-embedded biopsies from 47 women (33-54 years old) presenting abnormal cytology, with or without positive test for HPV (Linear Array Roche). On the other hand we investigated the association of EP-CAM immunohistochemical expression with differentiation-related and/or neoplastic changes in cervical epithelium.Results: p63 expression was identified in basal/subcolumnar cells. Metaplastic (squamous or mucinous) epithelia, either alone or in conjunction with hyperplasia or carcinoma, exhibited the most intense staining, primarily in basal or subcolumnar cells. In dysplasia, exceded p63 immunostaining was noted in 1/3 lower epithelial layer. RT-PCT revealed a correlation between higher p63 mRNA levels and the severity of lesions.Conclusions: These results were also sustained by balance between cytokeratins detected by immunohistochemistry. HR HPV transformed cells maintain stem cell characteristics in advanced disease stage." @default.
- W2808471142 created "2018-06-21" @default.
- W2808471142 creator A5007393005 @default.
- W2808471142 creator A5008050974 @default.
- W2808471142 creator A5014257321 @default.
- W2808471142 creator A5037454823 @default.
- W2808471142 creator A5047921424 @default.
- W2808471142 creator A5066204528 @default.
- W2808471142 creator A5073607154 @default.
- W2808471142 creator A5078943068 @default.
- W2808471142 date "2008-04-01" @default.
- W2808471142 modified "2023-09-27" @default.
- W2808471142 title "p63 Value in Cervical Biopsy Tissues" @default.
- W2808471142 hasPublicationYear "2008" @default.
- W2808471142 type Work @default.
- W2808471142 sameAs 2808471142 @default.
- W2808471142 citedByCount "0" @default.
- W2808471142 crossrefType "journal-article" @default.
- W2808471142 hasAuthorship W2808471142A5007393005 @default.
- W2808471142 hasAuthorship W2808471142A5008050974 @default.
- W2808471142 hasAuthorship W2808471142A5014257321 @default.
- W2808471142 hasAuthorship W2808471142A5037454823 @default.
- W2808471142 hasAuthorship W2808471142A5047921424 @default.
- W2808471142 hasAuthorship W2808471142A5066204528 @default.
- W2808471142 hasAuthorship W2808471142A5073607154 @default.
- W2808471142 hasAuthorship W2808471142A5078943068 @default.
- W2808471142 hasConcept C121608353 @default.
- W2808471142 hasConcept C126322002 @default.
- W2808471142 hasConcept C138055712 @default.
- W2808471142 hasConcept C142724271 @default.
- W2808471142 hasConcept C204232928 @default.
- W2808471142 hasConcept C2775894508 @default.
- W2808471142 hasConcept C2775904963 @default.
- W2808471142 hasConcept C2775934546 @default.
- W2808471142 hasConcept C2777343196 @default.
- W2808471142 hasConcept C2777546739 @default.
- W2808471142 hasConcept C2777661416 @default.
- W2808471142 hasConcept C2777740455 @default.
- W2808471142 hasConcept C2778220009 @default.
- W2808471142 hasConcept C2778580637 @default.
- W2808471142 hasConcept C28328180 @default.
- W2808471142 hasConcept C31033888 @default.
- W2808471142 hasConcept C4224716 @default.
- W2808471142 hasConcept C529295009 @default.
- W2808471142 hasConcept C54355233 @default.
- W2808471142 hasConcept C555283112 @default.
- W2808471142 hasConcept C71924100 @default.
- W2808471142 hasConcept C86803240 @default.
- W2808471142 hasConceptScore W2808471142C121608353 @default.
- W2808471142 hasConceptScore W2808471142C126322002 @default.
- W2808471142 hasConceptScore W2808471142C138055712 @default.
- W2808471142 hasConceptScore W2808471142C142724271 @default.
- W2808471142 hasConceptScore W2808471142C204232928 @default.
- W2808471142 hasConceptScore W2808471142C2775894508 @default.
- W2808471142 hasConceptScore W2808471142C2775904963 @default.
- W2808471142 hasConceptScore W2808471142C2775934546 @default.
- W2808471142 hasConceptScore W2808471142C2777343196 @default.
- W2808471142 hasConceptScore W2808471142C2777546739 @default.
- W2808471142 hasConceptScore W2808471142C2777661416 @default.
- W2808471142 hasConceptScore W2808471142C2777740455 @default.
- W2808471142 hasConceptScore W2808471142C2778220009 @default.
- W2808471142 hasConceptScore W2808471142C2778580637 @default.
- W2808471142 hasConceptScore W2808471142C28328180 @default.
- W2808471142 hasConceptScore W2808471142C31033888 @default.
- W2808471142 hasConceptScore W2808471142C4224716 @default.
- W2808471142 hasConceptScore W2808471142C529295009 @default.
- W2808471142 hasConceptScore W2808471142C54355233 @default.
- W2808471142 hasConceptScore W2808471142C555283112 @default.
- W2808471142 hasConceptScore W2808471142C71924100 @default.
- W2808471142 hasConceptScore W2808471142C86803240 @default.
- W2808471142 hasLocation W28084711421 @default.
- W2808471142 hasOpenAccess W2808471142 @default.
- W2808471142 hasPrimaryLocation W28084711421 @default.
- W2808471142 hasRelatedWork W1520719781 @default.
- W2808471142 hasRelatedWork W1981283841 @default.
- W2808471142 hasRelatedWork W2010489316 @default.
- W2808471142 hasRelatedWork W2025034738 @default.
- W2808471142 hasRelatedWork W2028606326 @default.
- W2808471142 hasRelatedWork W2037892831 @default.
- W2808471142 hasRelatedWork W2050586039 @default.
- W2808471142 hasRelatedWork W2092453757 @default.
- W2808471142 hasRelatedWork W2145695910 @default.
- W2808471142 hasRelatedWork W2149670480 @default.
- W2808471142 hasRelatedWork W2262850927 @default.
- W2808471142 hasRelatedWork W2363932105 @default.
- W2808471142 hasRelatedWork W2399129844 @default.
- W2808471142 hasRelatedWork W2417964942 @default.
- W2808471142 hasRelatedWork W2435286784 @default.
- W2808471142 hasRelatedWork W26839700 @default.
- W2808471142 hasRelatedWork W2702852489 @default.
- W2808471142 hasRelatedWork W2744200217 @default.
- W2808471142 hasRelatedWork W2993491344 @default.
- W2808471142 hasRelatedWork W188285397 @default.
- W2808471142 hasVolume "16" @default.
- W2808471142 isParatext "false" @default.
- W2808471142 isRetracted "false" @default.
- W2808471142 magId "2808471142" @default.
- W2808471142 workType "article" @default.