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• W2808552968 abstract "Abstract Epidermal homeostasis requires balanced and coordinated adult stem cell renewal and differentiation. These processes are controlled by both extracellular signaling and by cell intrinsic transcription regulatory networks, yet how these control mechanisms are integrated to achieve this unclear. Here, we developed single-cell ID-seq and measured 69 antibody-DNA conjugates (including 34 phospho-specific epitopes) to study the activation state of signaling pathways during epidermal differentiation at the single-cell level. Computational pseudo-timing inference revealed activation of the JAK-STAT, WNT and BMP pathways along the epidermal differentiation trajectory. During differentiation, cells start producing BMP2 ligands and activate the canonical intracellular effectors SMAD1/5/9. Mechanistically, the BMP pathway is responsible for directly activating a specific transcription program that includes the key differentiation transcription factors MAF and MAFB to allow terminal differentiation. We propose that incorporating autocrine signaling pathway activation into a transcription regulatory network enables regional coordination of transcription programs during epidermal differentiation." @default.
• W2808552968 created "2018-06-21" @default.
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• W2808552968 date "2018-06-19" @default.
• W2808552968 modified "2023-09-24" @default.
• W2808552968 title "Single-cell ID-seq identifies BMP signaling as a driver of a late stage epidermal differentiation program" @default.
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• W2808552968 doi "https://doi.org/10.1101/350850" @default.
• W2808552968 hasPublicationYear "2018" @default.
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