Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808561350> ?p ?o ?g. }
- W2808561350 endingPage "2307" @default.
- W2808561350 startingPage "2297" @default.
- W2808561350 abstract "The free radical theory of aging suggests that reactive oxygen species (ROS) are responsible for age-related loss of cellular functions and, therefore, represent the main cause of aging. Redox regulation by thioredoxin-1 (TRX) plays a crucial role in responses to oxidative stress. We show that thioredoxin-interacting protein (TXNIP), a negative regulator of TRX, plays a major role in maintaining the redox status and, thereby, influences aging processes. This role of TXNIP is conserved from flies to humans. Age-dependent upregulation of TXNIP results in decreased stress resistance to oxidative challenge in primary human cells and in Drosophila. Experimental overexpression of TXNIP in flies shortens lifespan due to elevated oxidative DNA damage, whereas downregulation of TXNIP enhances oxidative stress resistance and extends lifespan." @default.
- W2808561350 created "2018-06-21" @default.
- W2808561350 creator A5014027073 @default.
- W2808561350 creator A5026397452 @default.
- W2808561350 creator A5034755405 @default.
- W2808561350 creator A5040929008 @default.
- W2808561350 creator A5046770146 @default.
- W2808561350 creator A5048715563 @default.
- W2808561350 creator A5057097411 @default.
- W2808561350 creator A5068388891 @default.
- W2808561350 creator A5069048670 @default.
- W2808561350 creator A5070010094 @default.
- W2808561350 date "2018-06-27" @default.
- W2808561350 modified "2023-10-14" @default.
- W2808561350 title "Enhanced expression of thioredoxin-interacting-protein regulates oxidative DNA damage and aging" @default.
- W2808561350 cites W1549902711 @default.
- W2808561350 cites W1565329973 @default.
- W2808561350 cites W1977706961 @default.
- W2808561350 cites W1978772332 @default.
- W2808561350 cites W1979165975 @default.
- W2808561350 cites W1982602899 @default.
- W2808561350 cites W1982647833 @default.
- W2808561350 cites W1986131701 @default.
- W2808561350 cites W1986423048 @default.
- W2808561350 cites W1992049458 @default.
- W2808561350 cites W1992533564 @default.
- W2808561350 cites W1995484312 @default.
- W2808561350 cites W2001277875 @default.
- W2808561350 cites W2005573382 @default.
- W2808561350 cites W2006569015 @default.
- W2808561350 cites W2018607502 @default.
- W2808561350 cites W2022037402 @default.
- W2808561350 cites W2054781812 @default.
- W2808561350 cites W2065413522 @default.
- W2808561350 cites W2066442023 @default.
- W2808561350 cites W2068862678 @default.
- W2808561350 cites W2073198282 @default.
- W2808561350 cites W2081543246 @default.
- W2808561350 cites W2086721251 @default.
- W2808561350 cites W2090139562 @default.
- W2808561350 cites W2091838922 @default.
- W2808561350 cites W2100465511 @default.
- W2808561350 cites W2113007696 @default.
- W2808561350 cites W2126525177 @default.
- W2808561350 cites W2128764621 @default.
- W2808561350 cites W2129298171 @default.
- W2808561350 cites W2132403739 @default.
- W2808561350 cites W2139703857 @default.
- W2808561350 cites W2147993424 @default.
- W2808561350 cites W2150132277 @default.
- W2808561350 cites W2150972545 @default.
- W2808561350 cites W2160472691 @default.
- W2808561350 cites W2164583810 @default.
- W2808561350 cites W2168743086 @default.
- W2808561350 cites W2170597525 @default.
- W2808561350 cites W2295666791 @default.
- W2808561350 cites W2315512556 @default.
- W2808561350 cites W2511049107 @default.
- W2808561350 cites W4211228471 @default.
- W2808561350 cites W4247896860 @default.
- W2808561350 cites W7239417 @default.
- W2808561350 doi "https://doi.org/10.1002/1873-3468.13156" @default.
- W2808561350 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6099297" @default.
- W2808561350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29897613" @default.
- W2808561350 hasPublicationYear "2018" @default.
- W2808561350 type Work @default.
- W2808561350 sameAs 2808561350 @default.
- W2808561350 citedByCount "37" @default.
- W2808561350 countsByYear W28085613502018 @default.
- W2808561350 countsByYear W28085613502019 @default.
- W2808561350 countsByYear W28085613502020 @default.
- W2808561350 countsByYear W28085613502021 @default.
- W2808561350 countsByYear W28085613502022 @default.
- W2808561350 countsByYear W28085613502023 @default.
- W2808561350 crossrefType "journal-article" @default.
- W2808561350 hasAuthorship W2808561350A5014027073 @default.
- W2808561350 hasAuthorship W2808561350A5026397452 @default.
- W2808561350 hasAuthorship W2808561350A5034755405 @default.
- W2808561350 hasAuthorship W2808561350A5040929008 @default.
- W2808561350 hasAuthorship W2808561350A5046770146 @default.
- W2808561350 hasAuthorship W2808561350A5048715563 @default.
- W2808561350 hasAuthorship W2808561350A5057097411 @default.
- W2808561350 hasAuthorship W2808561350A5068388891 @default.
- W2808561350 hasAuthorship W2808561350A5069048670 @default.
- W2808561350 hasAuthorship W2808561350A5070010094 @default.
- W2808561350 hasBestOaLocation W28085613501 @default.
- W2808561350 hasConcept C104317684 @default.
- W2808561350 hasConcept C127561419 @default.
- W2808561350 hasConcept C143425029 @default.
- W2808561350 hasConcept C185592680 @default.
- W2808561350 hasConcept C2776151105 @default.
- W2808561350 hasConcept C2779076967 @default.
- W2808561350 hasConcept C2908690268 @default.
- W2808561350 hasConcept C3623737 @default.
- W2808561350 hasConcept C48349386 @default.
- W2808561350 hasConcept C552990157 @default.
- W2808561350 hasConcept C55493867 @default.
- W2808561350 hasConcept C57600042 @default.