Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808567508> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2808567508 abstract "Objective: To report headache outcomes in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) Background: Headache is the most common symptom of IIH. The IIHTT enrolled 165 participants with mild visual loss to assess whether acetazolamide (ACZ) plus dietary management was superior to placebo (PBO) tablets plus dietary management in improving visual function at 6 months. We report the headache outcomes from the IIHTT. Design/Methods: Participants completed the Headache Impact Test -6 (HIT) and headache symptom questionnaires at each study visit. The Short Form-36 (SF-36) and National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and neuro-ophthalmic supplement (NOS) assessed quality of life at baseline and at 6 months. Group comparisons regarding HIT-6 total score were performed using two-sample t-tests. Group comparisons of proportions were performed using chi-square tests. Bivariate associations between variables were assessed using Spearman rank correlation coefficients. Logistic regression analyses determined the associations between baseline variables and the development of headache after baseline. Results: 139 (84%) enrollees had headaches at baseline and another 21 (13%) reported headaches in follow-up. 69% in the ACZ group and 68% randomized to PBO had persistent headaches at 6 months. There was no statistically significant difference in HIT-6 scores between treatment groups at 6 months. Development of headache after enrollment was not associated with CSF opening pressure (OP) at baseline (OR 0.997, 95% CI 0.991–1.003, p=0.32), baseline papilledema grade (OR 1.88, 95% CI 0.74–4.81, p=0.19), or baseline BMI (OR 1.02, 95% CI 0.97–1.08, p=0.39). HIT-6 score at 6 months was not significantly correlated with CSF OP at 6 months (r=0.12, p=0.29), the maximum dose of study drug taken (r=−0.09, p=0.48) or weight loss (r=0.02, p=0.80). Visual and general quality of life measures significantly correlated with the number of headache days at 6 months. Conclusions: Our findings provide class I evidence that CSF pressure and headaches are independent features of IIH. Study Supported by: National Eye Institute (1U10EY017281-01A1, DCBC 1U10EY017387-01A1, ARRA for NORDIC 3U10EY017281-01A1S1, and DCBC 1U10EY017387-01A1S1, and supplements for NORDIC 3U10EY017281-01A1S2) Disclosure: Dr. Friedman has received personal compensation for activities with Allergan, Teva, Eli Lilly, Avenir, Zosano, Amgen, Alder, Supernus and Trigemina as a speaker or advisory board member. Dr. Mejico has nothing to disclose. Dr. Subramanian has nothing to disclose. Dr. Quiros has nothing to disclose. Dr. McDermott has nothing to disclose." @default.
- W2808567508 created "2018-06-21" @default.
- W2808567508 creator A5013878572 @default.
- W2808567508 creator A5044678247 @default.
- W2808567508 creator A5045531332 @default.
- W2808567508 creator A5060095007 @default.
- W2808567508 creator A5084891824 @default.
- W2808567508 date "2017-04-18" @default.
- W2808567508 modified "2023-09-26" @default.
- W2808567508 title "Headache Outcomes in the Idiopathic Intracranial Hypertension Treatment Trial (S52.008)" @default.
- W2808567508 hasPublicationYear "2017" @default.
- W2808567508 type Work @default.
- W2808567508 sameAs 2808567508 @default.
- W2808567508 citedByCount "0" @default.
- W2808567508 crossrefType "journal-article" @default.
- W2808567508 hasAuthorship W2808567508A5013878572 @default.
- W2808567508 hasAuthorship W2808567508A5044678247 @default.
- W2808567508 hasAuthorship W2808567508A5045531332 @default.
- W2808567508 hasAuthorship W2808567508A5060095007 @default.
- W2808567508 hasAuthorship W2808567508A5084891824 @default.
- W2808567508 hasConcept C126322002 @default.
- W2808567508 hasConcept C141071460 @default.
- W2808567508 hasConcept C142724271 @default.
- W2808567508 hasConcept C159110408 @default.
- W2808567508 hasConcept C168563851 @default.
- W2808567508 hasConcept C1862650 @default.
- W2808567508 hasConcept C187212893 @default.
- W2808567508 hasConcept C204787440 @default.
- W2808567508 hasConcept C27081682 @default.
- W2808567508 hasConcept C2776367607 @default.
- W2808567508 hasConcept C2777405951 @default.
- W2808567508 hasConcept C2778107024 @default.
- W2808567508 hasConcept C2778541695 @default.
- W2808567508 hasConcept C2779804854 @default.
- W2808567508 hasConcept C2779951463 @default.
- W2808567508 hasConcept C2780954326 @default.
- W2808567508 hasConcept C2780966972 @default.
- W2808567508 hasConcept C42219234 @default.
- W2808567508 hasConcept C71924100 @default.
- W2808567508 hasConceptScore W2808567508C126322002 @default.
- W2808567508 hasConceptScore W2808567508C141071460 @default.
- W2808567508 hasConceptScore W2808567508C142724271 @default.
- W2808567508 hasConceptScore W2808567508C159110408 @default.
- W2808567508 hasConceptScore W2808567508C168563851 @default.
- W2808567508 hasConceptScore W2808567508C1862650 @default.
- W2808567508 hasConceptScore W2808567508C187212893 @default.
- W2808567508 hasConceptScore W2808567508C204787440 @default.
- W2808567508 hasConceptScore W2808567508C27081682 @default.
- W2808567508 hasConceptScore W2808567508C2776367607 @default.
- W2808567508 hasConceptScore W2808567508C2777405951 @default.
- W2808567508 hasConceptScore W2808567508C2778107024 @default.
- W2808567508 hasConceptScore W2808567508C2778541695 @default.
- W2808567508 hasConceptScore W2808567508C2779804854 @default.
- W2808567508 hasConceptScore W2808567508C2779951463 @default.
- W2808567508 hasConceptScore W2808567508C2780954326 @default.
- W2808567508 hasConceptScore W2808567508C2780966972 @default.
- W2808567508 hasConceptScore W2808567508C42219234 @default.
- W2808567508 hasConceptScore W2808567508C71924100 @default.
- W2808567508 hasLocation W28085675081 @default.
- W2808567508 hasOpenAccess W2808567508 @default.
- W2808567508 hasPrimaryLocation W28085675081 @default.
- W2808567508 hasRelatedWork W1937811850 @default.
- W2808567508 hasRelatedWork W2033728635 @default.
- W2808567508 hasRelatedWork W2039160209 @default.
- W2808567508 hasRelatedWork W2062407023 @default.
- W2808567508 hasRelatedWork W2166640699 @default.
- W2808567508 hasRelatedWork W2572646627 @default.
- W2808567508 hasRelatedWork W2588954438 @default.
- W2808567508 hasRelatedWork W2623279991 @default.
- W2808567508 hasRelatedWork W2777881032 @default.
- W2808567508 hasRelatedWork W2802385378 @default.
- W2808567508 hasRelatedWork W2885529412 @default.
- W2808567508 hasRelatedWork W2899506043 @default.
- W2808567508 hasRelatedWork W2913186854 @default.
- W2808567508 hasRelatedWork W3084499749 @default.
- W2808567508 hasRelatedWork W3109623479 @default.
- W2808567508 hasRelatedWork W3116772304 @default.
- W2808567508 hasRelatedWork W3132024420 @default.
- W2808567508 hasRelatedWork W3139212806 @default.
- W2808567508 hasRelatedWork W3159959646 @default.
- W2808567508 hasRelatedWork W3162054455 @default.
- W2808567508 hasVolume "88" @default.
- W2808567508 isParatext "false" @default.
- W2808567508 isRetracted "false" @default.
- W2808567508 magId "2808567508" @default.
- W2808567508 workType "article" @default.