Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808570189> ?p ?o ?g. }
- W2808570189 abstract "Abstract Checkpoint blockade immunotherapy enhances systemic antitumor immune response by targeting T cell inhibitory pathways; however, inadequate T cell infiltration has limited its anticancer efficacy. Radiotherapy (RT) has local immunomodulatory effects that can alter the microenvironment of irradiated tumors to synergize with immune checkpoint blockade. However, even with high doses of radiation, RT has rarely elicited systemic immune responses. Herein, we report the design of two porous Hf-based nanoscale metal-organic frameworks (nMOFs) as highly effective radioenhancers that significantly outperform HfO 2 , a clinically investigated radioenhancer in vitro and in vivo. Importantly, the combination of nMOF-mediated low-dose RT with an anti-programmed death-ligand 1 antibody effectively extends the local therapeutic effects of RT to distant tumors via abscopal effects. Our work establishes the feasibility of combining nMOF-mediated RT with immune checkpoint blockade to elicit systemic antitumor immunity in non-T cell-inflamed tumor phenotypes without normal tissue toxicity, promising to broaden the application of checkpoint blockade immunotherapy." @default.
- W2808570189 created "2018-06-21" @default.
- W2808570189 creator A5019641122 @default.
- W2808570189 creator A5021817343 @default.
- W2808570189 creator A5030938999 @default.
- W2808570189 creator A5047355204 @default.
- W2808570189 creator A5054855052 @default.
- W2808570189 creator A5057193669 @default.
- W2808570189 creator A5058919712 @default.
- W2808570189 creator A5075196471 @default.
- W2808570189 creator A5076498464 @default.
- W2808570189 creator A5076884619 @default.
- W2808570189 date "2018-06-15" @default.
- W2808570189 modified "2023-10-18" @default.
- W2808570189 title "Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy" @default.
- W2808570189 cites W1524125877 @default.
- W2808570189 cites W1598843567 @default.
- W2808570189 cites W1893566975 @default.
- W2808570189 cites W1940241680 @default.
- W2808570189 cites W1973849409 @default.
- W2808570189 cites W1985006984 @default.
- W2808570189 cites W1986238480 @default.
- W2808570189 cites W1992699637 @default.
- W2808570189 cites W1994718961 @default.
- W2808570189 cites W1999020268 @default.
- W2808570189 cites W2001816519 @default.
- W2808570189 cites W2007062068 @default.
- W2808570189 cites W2008428974 @default.
- W2808570189 cites W2022837929 @default.
- W2808570189 cites W2027630134 @default.
- W2808570189 cites W2032166347 @default.
- W2808570189 cites W2039123767 @default.
- W2808570189 cites W2042699075 @default.
- W2808570189 cites W2044835625 @default.
- W2808570189 cites W2046972425 @default.
- W2808570189 cites W2049553585 @default.
- W2808570189 cites W2051606234 @default.
- W2808570189 cites W2052727153 @default.
- W2808570189 cites W2060070314 @default.
- W2808570189 cites W2060469376 @default.
- W2808570189 cites W2075647502 @default.
- W2808570189 cites W2075879891 @default.
- W2808570189 cites W2076866768 @default.
- W2808570189 cites W2090750060 @default.
- W2808570189 cites W2093424661 @default.
- W2808570189 cites W2095242372 @default.
- W2808570189 cites W2108789863 @default.
- W2808570189 cites W2115712044 @default.
- W2808570189 cites W2118278569 @default.
- W2808570189 cites W2128680272 @default.
- W2808570189 cites W2132834292 @default.
- W2808570189 cites W2133739473 @default.
- W2808570189 cites W2140828776 @default.
- W2808570189 cites W2156311525 @default.
- W2808570189 cites W2159094759 @default.
- W2808570189 cites W2162255724 @default.
- W2808570189 cites W2164918134 @default.
- W2808570189 cites W2198709783 @default.
- W2808570189 cites W2278059930 @default.
- W2808570189 cites W2324532698 @default.
- W2808570189 cites W2327712306 @default.
- W2808570189 cites W2529570061 @default.
- W2808570189 cites W2560367415 @default.
- W2808570189 cites W2606461122 @default.
- W2808570189 cites W2723891822 @default.
- W2808570189 cites W2742204633 @default.
- W2808570189 cites W2794625586 @default.
- W2808570189 cites W4238864742 @default.
- W2808570189 cites W745919197 @default.
- W2808570189 doi "https://doi.org/10.1038/s41467-018-04703-w" @default.
- W2808570189 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6003951" @default.
- W2808570189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29907739" @default.
- W2808570189 hasPublicationYear "2018" @default.
- W2808570189 type Work @default.
- W2808570189 sameAs 2808570189 @default.
- W2808570189 citedByCount "234" @default.
- W2808570189 countsByYear W28085701892018 @default.
- W2808570189 countsByYear W28085701892019 @default.
- W2808570189 countsByYear W28085701892020 @default.
- W2808570189 countsByYear W28085701892021 @default.
- W2808570189 countsByYear W28085701892022 @default.
- W2808570189 countsByYear W28085701892023 @default.
- W2808570189 crossrefType "journal-article" @default.
- W2808570189 hasAuthorship W2808570189A5019641122 @default.
- W2808570189 hasAuthorship W2808570189A5021817343 @default.
- W2808570189 hasAuthorship W2808570189A5030938999 @default.
- W2808570189 hasAuthorship W2808570189A5047355204 @default.
- W2808570189 hasAuthorship W2808570189A5054855052 @default.
- W2808570189 hasAuthorship W2808570189A5057193669 @default.
- W2808570189 hasAuthorship W2808570189A5058919712 @default.
- W2808570189 hasAuthorship W2808570189A5075196471 @default.
- W2808570189 hasAuthorship W2808570189A5076498464 @default.
- W2808570189 hasAuthorship W2808570189A5076884619 @default.
- W2808570189 hasBestOaLocation W28085701891 @default.
- W2808570189 hasConcept C126322002 @default.
- W2808570189 hasConcept C170493617 @default.
- W2808570189 hasConcept C203014093 @default.
- W2808570189 hasConcept C2776090121 @default.
- W2808570189 hasConcept C2776107976 @default.
- W2808570189 hasConcept C2777701055 @default.