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- W2808583944 abstract "Systemic lupus erythematosus (SLE) is the prototype of systemicautoimmune diseases. It affects predominantly women in their reproductiveyears. Remissions and relapses characterize the disease. The clinicalmanifestations and their severity in individual patients may vary considerablyand, therefore, the treatment strategy needs to be tailored accordingly.Systemic lupus erythematosus (SLE) has frequent and potentially seriousneuropsychiatric (NP) manifestations that are of importance in the managementof the disease. Lack of a diagnostic gold standard and ambiguous terminologyhave hampered epidemiologic research in neuropsychiatric systemic lupuserythematosus (NPSLE). The reported prevalence of NPSLE varies widely,from 14% to 75%, because of inconsistent classifications and selected patientpopulations in tertiary referral centers. A nomenclature system recentlydeveloped by the American College of Rheumatology (ACR) is the first steptoward standardized and internationally accepted classification ofNPSLE. This nomenclature comprises case definitions includingdiagnostic criteria, exclusions, and methods of ascertainment for a total of 19syndromes. The purpose of this cross-sectional, hospital based study is toassess the validity of the ACR nomenclature and case definitions for NPSLE.1. Atleast one Neuropsychiatric SLE (NPSLE) syndrome was found in 70%of SLE patients admitted.2. Females were more predominant (F:M=20:1)3. 9.5% of patients presented with NPSLE as the first manifestation of SLE.4. Headache was the most common presentation seen in 54.7% patientsfollowed by mood disorders(depression) (47.6%). Migraine without aurawas the most common type of headache noted.5. Psychosis was seen only in 12% of patients.6. Peripheral nerve disorders were seen in 12% of the patients.7. Seizure disorder was seen in 33% of patients, generalized seizure beingthe most common among them.8. Tremor disorder seen in 4.8% of the patients.9. Some of the defined NPSLE syndromes like demyelinating diseases,aseptic meningitis, myelopathy, anxiety disorder, autonomic disorder,myasthenia, cranial neuropathy and plexopathy were not observed in thepresent study." @default.
- W2808583944 created "2018-06-21" @default.
- W2808583944 creator A5000024903 @default.
- W2808583944 date "2010-08-01" @default.
- W2808583944 modified "2023-09-27" @default.
- W2808583944 title "A study on Neuropsychiatric Manifestations of Systemic Lupus Erythematosus." @default.
- W2808583944 hasPublicationYear "2010" @default.
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