Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808584889> ?p ?o ?g. }
- W2808584889 abstract "Aurora A kinase (AURKA) is a major regulator of mitosis and an important driver of cancer progression. The roles of AURKA outside of mitosis, and how these might contribute to cancer progression, are not well understood. Here, we show that a fraction of cytoplasmic AURKA is associated with mitochondria, co-fractionating in cell extracts and interacting with mitochondrial proteins by reciprocal co-immunoprecipitation. We have also found that the dynamics of the mitochondrial network are sensitive to AURKA inhibition, depletion or overexpression. This can account for the different mitochondrial morphologies observed in RPE-1 and U2OS cell lines, which show very different levels of expression of AURKA. We identify the mitochondrial fraction of AURKA as influencing mitochondrial morphology, because an N-terminally truncated version of the kinase that does not localize to mitochondria does not affect the mitochondrial network. We identify a cryptic mitochondrial targeting sequence in the AURKA N-terminus and discuss how alternative conformations of the protein may influence its cytoplasmic fate." @default.
- W2808584889 created "2018-06-21" @default.
- W2808584889 creator A5009414571 @default.
- W2808584889 creator A5010848840 @default.
- W2808584889 creator A5021844617 @default.
- W2808584889 creator A5034805318 @default.
- W2808584889 creator A5041311509 @default.
- W2808584889 creator A5062955549 @default.
- W2808584889 creator A5087418165 @default.
- W2808584889 date "2018-06-01" @default.
- W2808584889 modified "2023-10-10" @default.
- W2808584889 title "Constitutive regulation of mitochondrial morphology by Aurora A kinase depends on a predicted cryptic targeting sequence at the N-terminus" @default.
- W2808584889 cites W1543378549 @default.
- W2808584889 cites W1657157395 @default.
- W2808584889 cites W1840016496 @default.
- W2808584889 cites W1972726904 @default.
- W2808584889 cites W1975035163 @default.
- W2808584889 cites W1985390453 @default.
- W2808584889 cites W1989026904 @default.
- W2808584889 cites W1997982747 @default.
- W2808584889 cites W2003607443 @default.
- W2808584889 cites W2008174897 @default.
- W2808584889 cites W2011499343 @default.
- W2808584889 cites W2015807143 @default.
- W2808584889 cites W2016559686 @default.
- W2808584889 cites W2021558950 @default.
- W2808584889 cites W2031069616 @default.
- W2808584889 cites W2031128960 @default.
- W2808584889 cites W2042981624 @default.
- W2808584889 cites W2052543023 @default.
- W2808584889 cites W2068876164 @default.
- W2808584889 cites W2069910776 @default.
- W2808584889 cites W2071110654 @default.
- W2808584889 cites W2083352151 @default.
- W2808584889 cites W2089047063 @default.
- W2808584889 cites W2092740775 @default.
- W2808584889 cites W2093877987 @default.
- W2808584889 cites W2095734738 @default.
- W2808584889 cites W2100659636 @default.
- W2808584889 cites W2104884643 @default.
- W2808584889 cites W2115470184 @default.
- W2808584889 cites W2119993590 @default.
- W2808584889 cites W2135158109 @default.
- W2808584889 cites W2137424160 @default.
- W2808584889 cites W2137429755 @default.
- W2808584889 cites W2138180163 @default.
- W2808584889 cites W2138760860 @default.
- W2808584889 cites W2139131640 @default.
- W2808584889 cites W2139636031 @default.
- W2808584889 cites W2140557275 @default.
- W2808584889 cites W2143368175 @default.
- W2808584889 cites W2155643523 @default.
- W2808584889 cites W2161320489 @default.
- W2808584889 cites W2265376588 @default.
- W2808584889 cites W2594299422 @default.
- W2808584889 cites W2617467085 @default.
- W2808584889 doi "https://doi.org/10.1098/rsob.170272" @default.
- W2808584889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6030116" @default.
- W2808584889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29899121" @default.
- W2808584889 hasPublicationYear "2018" @default.
- W2808584889 type Work @default.
- W2808584889 sameAs 2808584889 @default.
- W2808584889 citedByCount "24" @default.
- W2808584889 countsByYear W28085848892019 @default.
- W2808584889 countsByYear W28085848892020 @default.
- W2808584889 countsByYear W28085848892021 @default.
- W2808584889 countsByYear W28085848892023 @default.
- W2808584889 crossrefType "journal-article" @default.
- W2808584889 hasAuthorship W2808584889A5009414571 @default.
- W2808584889 hasAuthorship W2808584889A5010848840 @default.
- W2808584889 hasAuthorship W2808584889A5021844617 @default.
- W2808584889 hasAuthorship W2808584889A5034805318 @default.
- W2808584889 hasAuthorship W2808584889A5041311509 @default.
- W2808584889 hasAuthorship W2808584889A5062955549 @default.
- W2808584889 hasAuthorship W2808584889A5087418165 @default.
- W2808584889 hasBestOaLocation W28085848891 @default.
- W2808584889 hasConcept C104317684 @default.
- W2808584889 hasConcept C184235292 @default.
- W2808584889 hasConcept C190062978 @default.
- W2808584889 hasConcept C24586158 @default.
- W2808584889 hasConcept C28859421 @default.
- W2808584889 hasConcept C54355233 @default.
- W2808584889 hasConcept C71829478 @default.
- W2808584889 hasConcept C81885089 @default.
- W2808584889 hasConcept C86803240 @default.
- W2808584889 hasConcept C93304396 @default.
- W2808584889 hasConcept C95444343 @default.
- W2808584889 hasConceptScore W2808584889C104317684 @default.
- W2808584889 hasConceptScore W2808584889C184235292 @default.
- W2808584889 hasConceptScore W2808584889C190062978 @default.
- W2808584889 hasConceptScore W2808584889C24586158 @default.
- W2808584889 hasConceptScore W2808584889C28859421 @default.
- W2808584889 hasConceptScore W2808584889C54355233 @default.
- W2808584889 hasConceptScore W2808584889C71829478 @default.
- W2808584889 hasConceptScore W2808584889C81885089 @default.
- W2808584889 hasConceptScore W2808584889C86803240 @default.
- W2808584889 hasConceptScore W2808584889C93304396 @default.
- W2808584889 hasConceptScore W2808584889C95444343 @default.
- W2808584889 hasFunder F4320319985 @default.
- W2808584889 hasFunder F4320320879 @default.