FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808587499> ?p ?o ?g. }

• W2808587499 endingPage "73" @default.
• W2808587499 startingPage "68" @default.
• W2808587499 abstract "Lymphocytes play a key role in asthma pathophysiology, secreting various cytokines involved in chronic inflammation. CHF6001 is a highly potent and selective phosphodiesterase type 4 (PDE4) inhibitor designed for inhaled administration and has been shown to reduce the late asthmatic response. However, the effect of PDE4 inhibition on the different cytokines produced by lung lymphocytes from asthma patients has not been examined. This study investigated the anti-inflammatory effects of CHF6001 and the corticosteroid, 17-BMP, on T-cell receptor (TCR) stimulated Th1, Th2 and Th17 cytokine release from bronchoalveolar lavage (BAL) cells from mild (n = 12) and moderate asthma (n = 12) patients. CHF6001 inhibited IFNγ, IL-2 and IL-17, but not IL-13, secretion from both mild and moderate asthma patient BAL cells; there was a greater effect on IFNγ and IL-2 than IL-17. The corticosteroid inhibited all four cytokines from both patient groups, but was less effective in cells from more severe patients. CHF6001 had a greater inhibitory effect on IFNγ and IL-2 than 17-BMP. The PDE4 inhibitor CHF6001 had a greater effect on Th1 cytokines from TCR-stimulated BAL cells than corticosteroid. This pharmacological effect suggests the therapeutic potential for PDE4 inhibitors to be used in the subset of more severe asthma patients with increased airway levels of IFNγ." @default.
• W2808587499 created "2018-06-21" @default.
• W2808587499 creator A5003358525 @default.
• W2808587499 creator A5068917661 @default.
• W2808587499 creator A5076376198 @default.
• W2808587499 creator A5079135277 @default.
• W2808587499 creator A5086450166 @default.
• W2808587499 creator A5087386233 @default.
• W2808587499 creator A5090083154 @default.
• W2808587499 date "2019-01-01" @default.
• W2808587499 modified "2023-09-25" @default.
• W2808587499 title "Anti-inflammatory effects of the phosphodiesterase type 4 inhibitor CHF6001 on bronchoalveolar lavage lymphocytes from asthma patients" @default.
• W2808587499 cites W1095614472 @default.
• W2808587499 cites W1755789113 @default.
• W2808587499 cites W1902502662 @default.
• W2808587499 cites W1940020093 @default.
• W2808587499 cites W1980105210 @default.
• W2808587499 cites W2012612191 @default.
• W2808587499 cites W2034313895 @default.
• W2808587499 cites W2049374415 @default.
• W2808587499 cites W2064570290 @default.
• W2808587499 cites W2068467454 @default.
• W2808587499 cites W2070025576 @default.
• W2808587499 cites W2082848636 @default.
• W2808587499 cites W2088613483 @default.
• W2808587499 cites W2102614658 @default.
• W2808587499 cites W2124554987 @default.
• W2808587499 cites W2124742434 @default.
• W2808587499 cites W2131055445 @default.
• W2808587499 cites W2136699311 @default.
• W2808587499 cites W2139265563 @default.
• W2808587499 cites W2139714816 @default.
• W2808587499 cites W2140271923 @default.
• W2808587499 cites W2141030992 @default.
• W2808587499 cites W2147533486 @default.
• W2808587499 cites W2160989034 @default.
• W2808587499 cites W2164092307 @default.
• W2808587499 cites W2235257650 @default.
• W2808587499 cites W2265637850 @default.
• W2808587499 cites W2277842296 @default.
• W2808587499 cites W2329012680 @default.
• W2808587499 cites W2413517616 @default.
• W2808587499 cites W2461375381 @default.
• W2808587499 cites W2466234801 @default.
• W2808587499 cites W2529532071 @default.
• W2808587499 cites W2560109127 @default.
• W2808587499 cites W2606344473 @default.
• W2808587499 cites W2618729389 @default.
• W2808587499 cites W2728825901 @default.
• W2808587499 cites W2730604407 @default.
• W2808587499 cites W2795837720 @default.
• W2808587499 cites W4237864178 @default.
• W2808587499 doi "https://doi.org/10.1016/j.cyto.2018.06.007" @default.
• W2808587499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29934047" @default.
• W2808587499 hasPublicationYear "2019" @default.
• W2808587499 type Work @default.
• W2808587499 sameAs 2808587499 @default.
• W2808587499 citedByCount "13" @default.
• W2808587499 countsByYear W28085874992019 @default.
• W2808587499 countsByYear W28085874992020 @default.
• W2808587499 countsByYear W28085874992021 @default.
• W2808587499 countsByYear W28085874992022 @default.
• W2808587499 countsByYear W28085874992023 @default.
• W2808587499 crossrefType "journal-article" @default.
• W2808587499 hasAuthorship W2808587499A5003358525 @default.
• W2808587499 hasAuthorship W2808587499A5068917661 @default.
• W2808587499 hasAuthorship W2808587499A5076376198 @default.
• W2808587499 hasAuthorship W2808587499A5079135277 @default.
• W2808587499 hasAuthorship W2808587499A5086450166 @default.
• W2808587499 hasAuthorship W2808587499A5087386233 @default.
• W2808587499 hasAuthorship W2808587499A5090083154 @default.
• W2808587499 hasBestOaLocation W28085874992 @default.
• W2808587499 hasConcept C126322002 @default.
• W2808587499 hasConcept C141105273 @default.
• W2808587499 hasConcept C159654299 @default.
• W2808587499 hasConcept C203014093 @default.
• W2808587499 hasConcept C2776042228 @default.
• W2808587499 hasConcept C2776766087 @default.
• W2808587499 hasConcept C2776804153 @default.
• W2808587499 hasConcept C2776914184 @default.
• W2808587499 hasConcept C2777714996 @default.
• W2808587499 hasConcept C2777961210 @default.
• W2808587499 hasConcept C2778690821 @default.
• W2808587499 hasConcept C71924100 @default.
• W2808587499 hasConcept C98274493 @default.
• W2808587499 hasConceptScore W2808587499C126322002 @default.
• W2808587499 hasConceptScore W2808587499C141105273 @default.
• W2808587499 hasConceptScore W2808587499C159654299 @default.
• W2808587499 hasConceptScore W2808587499C203014093 @default.
• W2808587499 hasConceptScore W2808587499C2776042228 @default.
• W2808587499 hasConceptScore W2808587499C2776766087 @default.
• W2808587499 hasConceptScore W2808587499C2776804153 @default.
• W2808587499 hasConceptScore W2808587499C2776914184 @default.
• W2808587499 hasConceptScore W2808587499C2777714996 @default.
• W2808587499 hasConceptScore W2808587499C2777961210 @default.
• W2808587499 hasConceptScore W2808587499C2778690821 @default.
• W2808587499 hasConceptScore W2808587499C71924100 @default.
• W2808587499 hasConceptScore W2808587499C98274493 @default.

• next