FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808587745> ?p ?o ?g. }

• W2808587745 abstract "Objectives Human Urinary Kallidinogenase (HUK) is a tissue kallikrein that plays neuroprotective roles in ischemic conditions via different mechanisms. Mild hypothermia (MH) is another robust neuroprotectant that reduces mortality but does not profoundly ameliorate the neurological outcome in hypoxic-ischemic encephalopathy (HIE) patients. However, whether the combination of HUK and MH can be used as a promising neuroprotective treatment in HIE is unknown. Methods One-hundred-forty-four adult Wistar rats were randomly divided into 5 groups: Sham, HIE, HUK, MH and a combination of HUK and MH treatment. The HIE rat model was established by right carotid dissection followed by hypoxia aspiration. The survival curve was created within 7 days, and the neurological severity scores (NSS) were assessed at days 0, 1, 3, and 7. Nissl staining, TUNEL, immunofluorescent staining and western blotting were used to evaluate neuronal survival, apoptosis and necrosis, tight-junction proteins Claudin-1 and ZO-1, vascular endothelial growth factor (VEGF), doublecortex (DCX), bradykinin receptor B1, B2 and Ki67 staining. Results: The combined treatment rescued all HIE rats from death and had a best survival curve compared to HIE. The Combination also reduced the NSS scores after HIE at days 7, better than HUK or MH alone. The combination of HUK and MH reserved more cells in Nissl staining and inhibited neuronal apoptosis and necrosis as well as significantly attenuated HIE-induced decreases in claudin-1, ZO-1, cyclin D1, and BDKRB1/B2 receptors in comparison to HUK or MH treatment alone. Moreover, the combined treatment increased the expression of VEGF and DXC as well as the number of Ki67-labeled cells. Conclusions This study demonstrates that both HUK and MH are neuroprotective after HIE insult; however, the combined therapy with HUK and MH enhanced the efficiency and efficacy of either therapy alone in the treatment of HIE, at least partially by promoting angiogenesis and regeneration and rescuing tight-junction loss. The combination of HUK and MH seems to be a feasible and promising clinical strategy to alleviate cerebral injury following HIE insult." @default.
• W2808587745 created "2018-06-21" @default.
• W2808587745 creator A5000422885 @default.
• W2808587745 creator A5002130552 @default.
• W2808587745 creator A5003625073 @default.
• W2808587745 creator A5010674113 @default.
• W2808587745 creator A5020723643 @default.
• W2808587745 creator A5034067305 @default.
• W2808587745 creator A5039924898 @default.
• W2808587745 creator A5040141080 @default.
• W2808587745 creator A5052607928 @default.
• W2808587745 creator A5053405648 @default.
• W2808587745 creator A5063579534 @default.
• W2808587745 creator A5073528622 @default.
• W2808587745 date "2018-07-11" @default.
• W2808587745 modified "2023-10-16" @default.
• W2808587745 title "The Combination of Human Urinary Kallidinogenase and Mild Hypothermia Protects Adult Rats Against Hypoxic-Ischemic Encephalopathy-Induced Injury by Promoting Angiogenesis and Regeneration" @default.
• W2808587745 cites W1516339135 @default.
• W2808587745 cites W1532965294 @default.
• W2808587745 cites W1577396411 @default.
• W2808587745 cites W1586228513 @default.
• W2808587745 cites W1787951607 @default.
• W2808587745 cites W187584177 @default.
• W2808587745 cites W1952301728 @default.
• W2808587745 cites W1964210744 @default.
• W2808587745 cites W1966067258 @default.
• W2808587745 cites W1981584489 @default.
• W2808587745 cites W1982713565 @default.
• W2808587745 cites W1986094463 @default.
• W2808587745 cites W1986346910 @default.
• W2808587745 cites W1992287860 @default.
• W2808587745 cites W1993241503 @default.
• W2808587745 cites W1998321833 @default.
• W2808587745 cites W2008336268 @default.
• W2808587745 cites W2018508990 @default.
• W2808587745 cites W2022157317 @default.
• W2808587745 cites W2038351690 @default.
• W2808587745 cites W2040483330 @default.
• W2808587745 cites W2048080288 @default.
• W2808587745 cites W2063336926 @default.
• W2808587745 cites W2081175077 @default.
• W2808587745 cites W2089648703 @default.
• W2808587745 cites W2129553803 @default.
• W2808587745 cites W2129599482 @default.
• W2808587745 cites W2133665180 @default.
• W2808587745 cites W2133693969 @default.
• W2808587745 cites W2171768182 @default.
• W2808587745 cites W2187679533 @default.
• W2808587745 cites W2241072668 @default.
• W2808587745 cites W2269332153 @default.
• W2808587745 cites W2278321648 @default.
• W2808587745 cites W2288888153 @default.
• W2808587745 cites W2297072255 @default.
• W2808587745 cites W2312900114 @default.
• W2808587745 cites W2322169884 @default.
• W2808587745 cites W2342533302 @default.
• W2808587745 cites W2545813923 @default.
• W2808587745 cites W2559712616 @default.
• W2808587745 cites W2564209709 @default.
• W2808587745 cites W2581378318 @default.
• W2808587745 cites W2592025523 @default.
• W2808587745 cites W2593413052 @default.
• W2808587745 cites W2607487354 @default.
• W2808587745 cites W2617878584 @default.
• W2808587745 cites W2621245281 @default.
• W2808587745 cites W2719321796 @default.
• W2808587745 cites W2749470720 @default.
• W2808587745 cites W2755849992 @default.
• W2808587745 cites W2757302240 @default.
• W2808587745 cites W2765463414 @default.
• W2808587745 doi "https://doi.org/10.3389/fnagi.2018.00196" @default.
• W2808587745 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6050362" @default.
• W2808587745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30050428" @default.
• W2808587745 hasPublicationYear "2018" @default.
• W2808587745 type Work @default.
• W2808587745 sameAs 2808587745 @default.
• W2808587745 citedByCount "6" @default.
• W2808587745 countsByYear W28085877452019 @default.
• W2808587745 countsByYear W28085877452020 @default.
• W2808587745 countsByYear W28085877452021 @default.
• W2808587745 countsByYear W28085877452022 @default.
• W2808587745 countsByYear W28085877452023 @default.
• W2808587745 crossrefType "journal-article" @default.
• W2808587745 hasAuthorship W2808587745A5000422885 @default.
• W2808587745 hasAuthorship W2808587745A5002130552 @default.
• W2808587745 hasAuthorship W2808587745A5003625073 @default.
• W2808587745 hasAuthorship W2808587745A5010674113 @default.
• W2808587745 hasAuthorship W2808587745A5020723643 @default.
• W2808587745 hasAuthorship W2808587745A5034067305 @default.
• W2808587745 hasAuthorship W2808587745A5039924898 @default.
• W2808587745 hasAuthorship W2808587745A5040141080 @default.
• W2808587745 hasAuthorship W2808587745A5052607928 @default.
• W2808587745 hasAuthorship W2808587745A5053405648 @default.
• W2808587745 hasAuthorship W2808587745A5063579534 @default.
• W2808587745 hasAuthorship W2808587745A5073528622 @default.
• W2808587745 hasBestOaLocation W28085877451 @default.
• W2808587745 hasConcept C126322002 @default.
• W2808587745 hasConcept C134018914 @default.
• W2808587745 hasConcept C142724271 @default.
• W2808587745 hasConcept C167734588 @default.

• next