Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808594805> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2808594805 endingPage "34" @default.
- W2808594805 startingPage "23" @default.
- W2808594805 abstract "Myostatin is a major factor involved in the regulation of skeletal muscle protein mass. High myostatin levels have been associated with an increase in myotube shrinkage. Enhanced myostatin expression is caused by pro-catabolic reactions involving compounds such as tumor necrosis factor (TNF)-α. The present study investigated the effects of agaro-oligosaccharides (AOSs) on hypercatabolism of myotubes exposed to TNF-α. C2C12 myotubes exposed to TNF-α in the presence or absence of AOSs. Myotube exposure to TNF-α resulted in a reduction in the amount of myosin heavy chain (MyHC) protein and a decrease in myotube diameter, which was associated with increased myostatin mRNA expression. AOSs prevented TNF-α-induced MyHC protein loss and restored normal myostatin mRNA levels, with agarobiose and agarotetraose effectively suppressing the hyperexpression of the mRNA. In addition, expression levels of the known myostatin inhibitors, latent transforming growth factor beta binding protein 3 (Ltbp3) and growth and differentiation factor-associated serum protein 1 (Gasp1) mRNAs, decreased more in TNF-α-induced myotubes than in the TNF-α-free control, possibly resulting in myostatin upregulation. However, AOSs restored nearly normal expression levels of Ltbp3 and Gasp1 mRNA, potentially suppressing myostatin expression. These findings suggest that AOSs could prevent myotube shrinkage induced by TNF-α." @default.
- W2808594805 created "2018-06-21" @default.
- W2808594805 creator A5001956420 @default.
- W2808594805 creator A5010935367 @default.
- W2808594805 creator A5028892000 @default.
- W2808594805 creator A5045984290 @default.
- W2808594805 creator A5048715010 @default.
- W2808594805 date "2018-01-01" @default.
- W2808594805 modified "2023-10-17" @default.
- W2808594805 title "Agaro-Oligosaccharides Prevent Myostatin Hyperexpression and Myosin Heavy Chain Protein Degradation in C2C12 Myotubes Induced by Tumor Necrosis Factor-<i>α</i>" @default.
- W2808594805 cites W1685618362 @default.
- W2808594805 cites W1884746705 @default.
- W2808594805 cites W1974582661 @default.
- W2808594805 cites W1974626477 @default.
- W2808594805 cites W1974894157 @default.
- W2808594805 cites W1987132484 @default.
- W2808594805 cites W1993475468 @default.
- W2808594805 cites W1996657560 @default.
- W2808594805 cites W2013819796 @default.
- W2808594805 cites W2019088303 @default.
- W2808594805 cites W2022510326 @default.
- W2808594805 cites W2023585072 @default.
- W2808594805 cites W2029209119 @default.
- W2808594805 cites W2030860331 @default.
- W2808594805 cites W2038285950 @default.
- W2808594805 cites W2042873218 @default.
- W2808594805 cites W2057999071 @default.
- W2808594805 cites W2077817700 @default.
- W2808594805 cites W2085500474 @default.
- W2808594805 cites W2091556210 @default.
- W2808594805 cites W2122594291 @default.
- W2808594805 cites W2155602382 @default.
- W2808594805 cites W2165868509 @default.
- W2808594805 cites W2166877291 @default.
- W2808594805 cites W2167512318 @default.
- W2808594805 doi "https://doi.org/10.4236/cellbio.2018.72003" @default.
- W2808594805 hasPublicationYear "2018" @default.
- W2808594805 type Work @default.
- W2808594805 sameAs 2808594805 @default.
- W2808594805 citedByCount "1" @default.
- W2808594805 countsByYear W28085948052022 @default.
- W2808594805 crossrefType "journal-article" @default.
- W2808594805 hasAuthorship W2808594805A5001956420 @default.
- W2808594805 hasAuthorship W2808594805A5010935367 @default.
- W2808594805 hasAuthorship W2808594805A5028892000 @default.
- W2808594805 hasAuthorship W2808594805A5045984290 @default.
- W2808594805 hasAuthorship W2808594805A5048715010 @default.
- W2808594805 hasBestOaLocation W28085948051 @default.
- W2808594805 hasConcept C104317684 @default.
- W2808594805 hasConcept C126322002 @default.
- W2808594805 hasConcept C127561419 @default.
- W2808594805 hasConcept C134018914 @default.
- W2808594805 hasConcept C17991360 @default.
- W2808594805 hasConcept C185592680 @default.
- W2808594805 hasConcept C2777488582 @default.
- W2808594805 hasConcept C2779959927 @default.
- W2808594805 hasConcept C3763915 @default.
- W2808594805 hasConcept C55493867 @default.
- W2808594805 hasConcept C60278653 @default.
- W2808594805 hasConcept C6997183 @default.
- W2808594805 hasConcept C71924100 @default.
- W2808594805 hasConcept C86803240 @default.
- W2808594805 hasConcept C95444343 @default.
- W2808594805 hasConceptScore W2808594805C104317684 @default.
- W2808594805 hasConceptScore W2808594805C126322002 @default.
- W2808594805 hasConceptScore W2808594805C127561419 @default.
- W2808594805 hasConceptScore W2808594805C134018914 @default.
- W2808594805 hasConceptScore W2808594805C17991360 @default.
- W2808594805 hasConceptScore W2808594805C185592680 @default.
- W2808594805 hasConceptScore W2808594805C2777488582 @default.
- W2808594805 hasConceptScore W2808594805C2779959927 @default.
- W2808594805 hasConceptScore W2808594805C3763915 @default.
- W2808594805 hasConceptScore W2808594805C55493867 @default.
- W2808594805 hasConceptScore W2808594805C60278653 @default.
- W2808594805 hasConceptScore W2808594805C6997183 @default.
- W2808594805 hasConceptScore W2808594805C71924100 @default.
- W2808594805 hasConceptScore W2808594805C86803240 @default.
- W2808594805 hasConceptScore W2808594805C95444343 @default.
- W2808594805 hasIssue "02" @default.
- W2808594805 hasLocation W28085948051 @default.
- W2808594805 hasOpenAccess W2808594805 @default.
- W2808594805 hasPrimaryLocation W28085948051 @default.
- W2808594805 hasRelatedWork W2095173030 @default.
- W2808594805 hasRelatedWork W217609350 @default.
- W2808594805 hasRelatedWork W2325087279 @default.
- W2808594805 hasRelatedWork W2463478234 @default.
- W2808594805 hasRelatedWork W2808594805 @default.
- W2808594805 hasRelatedWork W2889237711 @default.
- W2808594805 hasRelatedWork W2893460394 @default.
- W2808594805 hasRelatedWork W3161045724 @default.
- W2808594805 hasRelatedWork W4234907391 @default.
- W2808594805 hasRelatedWork W4313245571 @default.
- W2808594805 hasVolume "07" @default.
- W2808594805 isParatext "false" @default.
- W2808594805 isRetracted "false" @default.
- W2808594805 magId "2808594805" @default.
- W2808594805 workType "article" @default.