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- W2808622361 abstract "New biomaterials based on nanoparticles (NPs) carrying polyphenols-rich extracts (Cornus mas) recently showed promising anti-inflammatory activity in psoriasis. We aimed to understand how topically delivered silver and gold nanoparticles complexed with Cornus mas (Ag-NPs-CM, Au-NPs-CM) modulate inflammation in psoriasis at cellular and molecular level. The impact on psoriatic inflammation was assessed in vitro on pro-inflammatory macrophages, by clinical score, high-frequency ultrasonography and immunohistology of psoriasis plaques treated with Ag-NPs-CM, Au-NPs-CM or control. Incubation of pro-inflammatory macrophages with nanoparticles significantly decreased the release of NO, IL-12 and TNF-α. Immunofluorescence confirmed that nanoparticles significantly reduced CD68-positive macrophages and their IL-12 and TNF-α production in human psoriasis plaques. NPs-CM appear to repress NF-κB activation in macrophages, inhibiting the production of pro-inflammatory factors with causal role in psoriasis. Ag and Au NPs-CM represent a novel nanoparticle-based green technology which may provide an efficient tool for modern psoriasis therapy, circumventing immunosuppression-related side effects of biologicals." @default.
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- W2808622361 date "2018-07-29" @default.
- W2808622361 modified "2023-10-18" @default.
- W2808622361 title "Topical silver and gold nanoparticles complexed with <i>Cornus mas</i> suppress inflammation in human psoriasis plaques by inhibiting NF-κB activity" @default.
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- W2808622361 doi "https://doi.org/10.1111/exd.13707" @default.
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