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- W2808630484 abstract "BACKGROUND: Primary cilium has been hypothesized to play a role in the pathogenesis ofdentigerous cyst. The role of primary cilium associated protein, Polycystin-1, that hasbeen associated/ implicated in autosomal dominant polycystic kidney diseases has notbeen studied in dentigerous cysts.AIM AND OBJECTIVE: To study and compare the expression of Polycystin-1 in dentalfollicular tissue and dentigerous cyst and to identify the prevalence of dentigerous cyst inchronic renal disease patients.MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded tissue sections of Dentalfollicles (n=31) and Dentigerous cyst (n=15) which were confirmed clinically,radiographically and histopathologically were included in this study. The sections werestained with antibodies against Polycystin-1 and staining intensity was graded as nil (0),mild (+) , moderate (++) and intense ( +++) . Oral screening was also done for 100patients with chronic renal diseases.RESULTS: Polycystin-1 expression between dentigerous cyst and dental follicles werestatistically significant (P˂ 0.05). The intensity of staining varied between the epithelialcells of dentigerous cyst and dental follicles. It was observed that no clinical evidence ofdentigerous cyst was present in 100 chronic renal disease patients.CONCLUSION: The significant difference in the expression of Polycystin-1 betweendentigerous cyst and dental follicle suggests that Polycystin-1 can have a role in thetransformation of dental follicle to dentigerous cyst." @default.
- W2808630484 created "2018-06-21" @default.
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- W2808630484 date "2013-04-01" @default.
- W2808630484 modified "2023-09-26" @default.
- W2808630484 title "Evaluation of Polycystin-1 Expression in Dentigerous Cyst and Asymptomatic Dental Follicle." @default.
- W2808630484 hasPublicationYear "2013" @default.
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