Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808631904> ?p ?o ?g. }
- W2808631904 abstract "Streptococcus pneumoniae is the most common cause of community-acquired pneumonia (CAP). Despite the low prevalence of CAP caused by methicillin-resistant S. aureus (MRSA), CAP patients often receive empirical antibiotic therapy providing coverage for MRSA such as vancomycin or linezolid. An early differentiation between S. pneumoniae and S. aureus pneumonia can help to reduce the use of unnecessary antibiotics. The objective of this study was to identify candidate biomarkers that can discriminate pneumococcal from staphylococcal pneumonia. A genome-wide transcriptional analysis of lung and peripheral blood performed in murine models of S. pneumoniae and S. aureus lung infection identified an interferon signature specifically associated with S. pneumoniae infection. Prediction models built using a and support vector machine (SVM) and Monte Carlo cross-validation (MCCV), identified the combination of the interferon-induced chemokines CXCL9 and CXCL10 serum concentrations as the set of biomarkers with best sensitivity, specificity and predictive power that enabled an accurate discrimination between S. pneumoniae and S. aureus pneumonia. The predictive performance of these biomarkers was further validated in an independent cohort of mice. This study highlights the potential of serum CXCL9 and CXCL10 biomarkers as an adjunctive diagnostic tool that could facilitate prompt and correct pathogen-targeted therapy in CAP patients." @default.
- W2808631904 created "2018-06-21" @default.
- W2808631904 creator A5026062674 @default.
- W2808631904 creator A5033943280 @default.
- W2808631904 creator A5063804349 @default.
- W2808631904 creator A5064605655 @default.
- W2808631904 creator A5074513891 @default.
- W2808631904 date "2018-06-25" @default.
- W2808631904 modified "2023-10-17" @default.
- W2808631904 title "An Interferon Signature Discriminates Pneumococcal From Staphylococcal Pneumonia" @default.
- W2808631904 cites W1769504474 @default.
- W2808631904 cites W1893167071 @default.
- W2808631904 cites W1937319853 @default.
- W2808631904 cites W1976327004 @default.
- W2808631904 cites W2015524501 @default.
- W2808631904 cites W2028015105 @default.
- W2808631904 cites W203656311 @default.
- W2808631904 cites W2039774779 @default.
- W2808631904 cites W2065665494 @default.
- W2808631904 cites W2081491561 @default.
- W2808631904 cites W2086567743 @default.
- W2808631904 cites W2087723235 @default.
- W2808631904 cites W2108162055 @default.
- W2808631904 cites W2108244474 @default.
- W2808631904 cites W2108360478 @default.
- W2808631904 cites W2108632788 @default.
- W2808631904 cites W2110005071 @default.
- W2808631904 cites W2115127793 @default.
- W2808631904 cites W2115577286 @default.
- W2808631904 cites W2125066910 @default.
- W2808631904 cites W2133979383 @default.
- W2808631904 cites W2139915419 @default.
- W2808631904 cites W2143477093 @default.
- W2808631904 cites W2157403238 @default.
- W2808631904 cites W2158000594 @default.
- W2808631904 cites W2162110737 @default.
- W2808631904 cites W2164150624 @default.
- W2808631904 cites W2165482500 @default.
- W2808631904 cites W2168617764 @default.
- W2808631904 cites W2169332402 @default.
- W2808631904 cites W2330212472 @default.
- W2808631904 cites W2346951734 @default.
- W2808631904 cites W2489293415 @default.
- W2808631904 cites W2534163151 @default.
- W2808631904 cites W2556477841 @default.
- W2808631904 cites W2563162320 @default.
- W2808631904 cites W2736185952 @default.
- W2808631904 cites W2741328373 @default.
- W2808631904 cites W2756648723 @default.
- W2808631904 cites W3143755808 @default.
- W2808631904 cites W4205623122 @default.
- W2808631904 doi "https://doi.org/10.3389/fimmu.2018.01424" @default.
- W2808631904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6026679" @default.
- W2808631904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29988532" @default.
- W2808631904 hasPublicationYear "2018" @default.
- W2808631904 type Work @default.
- W2808631904 sameAs 2808631904 @default.
- W2808631904 citedByCount "9" @default.
- W2808631904 countsByYear W28086319042019 @default.
- W2808631904 countsByYear W28086319042021 @default.
- W2808631904 countsByYear W28086319042022 @default.
- W2808631904 countsByYear W28086319042023 @default.
- W2808631904 crossrefType "journal-article" @default.
- W2808631904 hasAuthorship W2808631904A5026062674 @default.
- W2808631904 hasAuthorship W2808631904A5033943280 @default.
- W2808631904 hasAuthorship W2808631904A5063804349 @default.
- W2808631904 hasAuthorship W2808631904A5064605655 @default.
- W2808631904 hasAuthorship W2808631904A5074513891 @default.
- W2808631904 hasBestOaLocation W28086319041 @default.
- W2808631904 hasConcept C126322002 @default.
- W2808631904 hasConcept C13373296 @default.
- W2808631904 hasConcept C17502307 @default.
- W2808631904 hasConcept C203014093 @default.
- W2808631904 hasConcept C2776703206 @default.
- W2808631904 hasConcept C2777914695 @default.
- W2808631904 hasConcept C2778980435 @default.
- W2808631904 hasConcept C2779489039 @default.
- W2808631904 hasConcept C2779892413 @default.
- W2808631904 hasConcept C2781253189 @default.
- W2808631904 hasConcept C2781414143 @default.
- W2808631904 hasConcept C501593827 @default.
- W2808631904 hasConcept C523546767 @default.
- W2808631904 hasConcept C54355233 @default.
- W2808631904 hasConcept C5858377 @default.
- W2808631904 hasConcept C71924100 @default.
- W2808631904 hasConcept C86803240 @default.
- W2808631904 hasConcept C8891405 @default.
- W2808631904 hasConcept C89423630 @default.
- W2808631904 hasConceptScore W2808631904C126322002 @default.
- W2808631904 hasConceptScore W2808631904C13373296 @default.
- W2808631904 hasConceptScore W2808631904C17502307 @default.
- W2808631904 hasConceptScore W2808631904C203014093 @default.
- W2808631904 hasConceptScore W2808631904C2776703206 @default.
- W2808631904 hasConceptScore W2808631904C2777914695 @default.
- W2808631904 hasConceptScore W2808631904C2778980435 @default.
- W2808631904 hasConceptScore W2808631904C2779489039 @default.
- W2808631904 hasConceptScore W2808631904C2779892413 @default.
- W2808631904 hasConceptScore W2808631904C2781253189 @default.
- W2808631904 hasConceptScore W2808631904C2781414143 @default.
- W2808631904 hasConceptScore W2808631904C501593827 @default.