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- W2808675497 abstract "Asthmatics sensitized to fungi are reported to have more severe asthma, yet the immunopathogenic pathways contributing to this severity have not been identified. In a pilot assessment of human asthmatics, those subjects sensitized to fungi demonstrated elevated levels of the common γ-chain cytokine IL-7 in lung lavage fluid, which negatively correlated with the lung function measurement PC20. Subsequently, we show that IL-7 administration during experimental fungal asthma worsened lung function and increased the levels of type 2 cytokines (IL-4, IL-5, IL-13), proallergic chemokines (CCL17, CCL22) and proinflammatory cytokines (IL-1α, IL-1β). Intriguingly, IL-7 administration also increased IL-22, which we have previously reported to drive immunopathogenic responses in experimental fungal asthma. Employing IL22CreR26ReYFP reporter mice, we identified γδ T cells, iNKT cells, CD4 T cells and ILC3s as sources of IL-22 during fungal asthma; however, only iNKT cells were significantly increased after IL-7 administration. IL-7-induced immunopathogenesis required both type 2 and IL-22 responses. Blockade of IL-7Rα in vivo resulted in attenuated IL-22 production, lower CCL22 levels, decreased iNKT cell, CD4 T-cell and eosinophil recruitment, yet paradoxically increased dynamic lung resistance. Collectively, these results suggest a complex role for IL-7 signaling in allergic fungal asthma." @default.
- W2808675497 created "2018-06-21" @default.
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- W2808675497 date "2018-09-01" @default.
- W2808675497 modified "2023-10-01" @default.
- W2808675497 title "The common γ-chain cytokine IL-7 promotes immunopathogenesis during fungal asthma" @default.
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- W2808675497 doi "https://doi.org/10.1038/s41385-018-0028-1" @default.
- W2808675497 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6319622" @default.
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- W2808675497 hasPublicationYear "2018" @default.
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