FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808727488> ?p ?o ?g. }

• W2808727488 endingPage "745" @default.
• W2808727488 startingPage "733" @default.
• W2808727488 abstract "To find out if the T cell repertoire is efficiently and specifically provoked in patients with breast cancer, we have investigated the clonotypes of main T cell subsets (based on Vβ-Chain) in tumor draining lymph nodes. CD4+ helper, CD8+ cytotoxic and (CD4+CD127dimCD25+) regulatory T cells, were ne gatively selected, and isolated, from lymph node mononuclear cells of 14 untreated patients with breast cancer. Four non-malignant patients, who underwent surgical operation, were also recruited as the control group. Based on sequences and new nomenclature of the T cell Receptor β Variables (TRBVs) available in the international ImMunoGeneTics (IMGT) database, 28 TRBV specific forward primers and two TRB Constant region (TRBC) specific reverse primers were developed to amplify all functional alleles. Fluorescent-labeled PCR products were then run on an ABI PRISM 310 Genetic-Analyzer. The data was analyzed by GeneMapper software version 3.1. Clonotype analysis suggested that activated T cells are present in breast cancer. More TRBV usage were detected among CD4+ helper and regulatory subsets, with Gaussian-like pattern in the majority of functional TRBV families; whereas CD8+ cytotoxic T cells showed oligoclonality in almost all TRBV families with one or two dominant peaks in each family. Similar pattern in some of these TRBVs were also observed among controls. Having no expression or polyclonality in the controls, the oligoclonal pattern observed in the TRBV18, however, appears to be specific to breast cancer patients. This phenomenon may reflect the existence of new antigenic stimulation(s) in BC patients, preferentially activating those clones of T cells that express TRBV18." @default.
• W2808727488 created "2018-06-29" @default.
• W2808727488 creator A5037367684 @default.
• W2808727488 creator A5055398153 @default.
• W2808727488 creator A5076640752 @default.
• W2808727488 creator A5078834482 @default.
• W2808727488 creator A5082928123 @default.
• W2808727488 date "2018-08-20" @default.
• W2808727488 modified "2023-10-17" @default.
• W2808727488 title "Analysis of T cell receptor repertoire based on Vβ chain in patients with breast cancer" @default.
• W2808727488 cites W1505727271 @default.
• W2808727488 cites W155752644 @default.
• W2808727488 cites W1588272261 @default.
• W2808727488 cites W1630979627 @default.
• W2808727488 cites W180732785 @default.
• W2808727488 cites W1926326783 @default.
• W2808727488 cites W1929611518 @default.
• W2808727488 cites W1935040042 @default.
• W2808727488 cites W1964372737 @default.
• W2808727488 cites W1990882383 @default.
• W2808727488 cites W1995047655 @default.
• W2808727488 cites W2002979890 @default.
• W2808727488 cites W2023120585 @default.
• W2808727488 cites W2035563026 @default.
• W2808727488 cites W2036374565 @default.
• W2808727488 cites W2043452201 @default.
• W2808727488 cites W2044931032 @default.
• W2808727488 cites W2053739508 @default.
• W2808727488 cites W2057977955 @default.
• W2808727488 cites W2061450798 @default.
• W2808727488 cites W2099516923 @default.
• W2808727488 cites W2100213817 @default.
• W2808727488 cites W2121937453 @default.
• W2808727488 cites W2124482949 @default.
• W2808727488 cites W2136573535 @default.
• W2808727488 cites W2137435397 @default.
• W2808727488 cites W2141550316 @default.
• W2808727488 cites W2144420540 @default.
• W2808727488 cites W2166374144 @default.
• W2808727488 cites W2332517313 @default.
• W2808727488 cites W2342183967 @default.
• W2808727488 cites W2435035615 @default.
• W2808727488 doi "https://doi.org/10.3233/cbm-181295" @default.
• W2808727488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29945345" @default.
• W2808727488 hasPublicationYear "2018" @default.
• W2808727488 type Work @default.
• W2808727488 sameAs 2808727488 @default.
• W2808727488 citedByCount "5" @default.
• W2808727488 countsByYear W28087274882019 @default.
• W2808727488 countsByYear W28087274882020 @default.
• W2808727488 countsByYear W28087274882021 @default.
• W2808727488 crossrefType "journal-article" @default.
• W2808727488 hasAuthorship W2808727488A5037367684 @default.
• W2808727488 hasAuthorship W2808727488A5055398153 @default.
• W2808727488 hasAuthorship W2808727488A5076640752 @default.
• W2808727488 hasAuthorship W2808727488A5078834482 @default.
• W2808727488 hasAuthorship W2808727488A5082928123 @default.
• W2808727488 hasConcept C121608353 @default.
• W2808727488 hasConcept C147483822 @default.
• W2808727488 hasConcept C154317977 @default.
• W2808727488 hasConcept C159654299 @default.
• W2808727488 hasConcept C167672396 @default.
• W2808727488 hasConcept C19317047 @default.
• W2808727488 hasConcept C202751555 @default.
• W2808727488 hasConcept C203014093 @default.
• W2808727488 hasConcept C2776090121 @default.
• W2808727488 hasConcept C2780849966 @default.
• W2808727488 hasConcept C530470458 @default.
• W2808727488 hasConcept C54355233 @default.
• W2808727488 hasConcept C86803240 @default.
• W2808727488 hasConcept C8891405 @default.
• W2808727488 hasConceptScore W2808727488C121608353 @default.
• W2808727488 hasConceptScore W2808727488C147483822 @default.
• W2808727488 hasConceptScore W2808727488C154317977 @default.
• W2808727488 hasConceptScore W2808727488C159654299 @default.
• W2808727488 hasConceptScore W2808727488C167672396 @default.
• W2808727488 hasConceptScore W2808727488C19317047 @default.
• W2808727488 hasConceptScore W2808727488C202751555 @default.
• W2808727488 hasConceptScore W2808727488C203014093 @default.
• W2808727488 hasConceptScore W2808727488C2776090121 @default.
• W2808727488 hasConceptScore W2808727488C2780849966 @default.
• W2808727488 hasConceptScore W2808727488C530470458 @default.
• W2808727488 hasConceptScore W2808727488C54355233 @default.
• W2808727488 hasConceptScore W2808727488C86803240 @default.
• W2808727488 hasConceptScore W2808727488C8891405 @default.
• W2808727488 hasIssue "4" @default.
• W2808727488 hasLocation W28087274881 @default.
• W2808727488 hasLocation W28087274882 @default.
• W2808727488 hasOpenAccess W2808727488 @default.
• W2808727488 hasPrimaryLocation W28087274881 @default.
• W2808727488 hasRelatedWork W113365012 @default.
• W2808727488 hasRelatedWork W1952047395 @default.
• W2808727488 hasRelatedWork W2018916009 @default.
• W2808727488 hasRelatedWork W2039054981 @default.
• W2808727488 hasRelatedWork W2040191638 @default.
• W2808727488 hasRelatedWork W2140205174 @default.
• W2808727488 hasRelatedWork W2796404166 @default.
• W2808727488 hasRelatedWork W3033140387 @default.

• next