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• W2808756935 abstract "Different fields of cancer management consider bone health to be of increasing clinical importance for patients: 1) presence of bone metastases in many solid tumors, 2) use of bone-targeted treatments in the reduction of bone metastasis, 3) effects of cancer treatment on reproductive hormones, critical for normal bone remodeling maintenance. Additionally, bone microenvironment is further complicated by the decline of ovarian sex steroid production and by the related increase in inflammatory factors linked to menopause, which result in accelerated bone loss and increased risk of osteoporosis (OP). Similarly, cancers and metastasis to bone showed a close relationship with sex hormones (particularly estrogen). Thus, these findings raise a question: Could pre-existing estrogen deficiency OP promote and/or influence cancer cell homing and tumor growth in bone? Although some preclinical and clinical evidence exists, it is mandatory to understand this aspect that would be relevant in the clinical theatre, where physicians need to understand the treatments available to reduce the risk of skeletal disease in cancer patients. This descriptive systematic review summarizes preclinical and clinical studies dealing with bimodal interactions between pre-existing estrogen deficiency OP and bone metastasis development and provides evidence supporting differences in tumor growth and colonization between healthy and OP status. Few studies evaluated the impact of estrogen deficiency OP on the susceptibility to bone metastases. Therefore, implementing biological knowledge, could help researchers and clinicians to have a better comprehension of the importance of pre- and post-menopausal bone microenvironment and its clinical implications for precision medicine in cancer patients." @default.
• W2808756935 created "2018-06-29" @default.
• W2808756935 creator A5022326448 @default.
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• W2808756935 date "2018-10-01" @default.
• W2808756935 modified "2023-09-27" @default.
• W2808756935 title "Link between estrogen deficiency osteoporosis and susceptibility to bone metastases: A way towards precision medicine in cancer patients" @default.
• W2808756935 cites W1505632988 @default.
• W2808756935 cites W1508715863 @default.
• W2808756935 cites W1593442063 @default.
• W2808756935 cites W1594526962 @default.
• W2808756935 cites W1965914119 @default.
• W2808756935 cites W1967252848 @default.
• W2808756935 cites W1969027216 @default.
• W2808756935 cites W1974389676 @default.
• W2808756935 cites W1975574047 @default.
• W2808756935 cites W1976866943 @default.
• W2808756935 cites W1981833135 @default.
• W2808756935 cites W1982066003 @default.
• W2808756935 cites W1985716862 @default.
• W2808756935 cites W1992885568 @default.
• W2808756935 cites W1995827857 @default.
• W2808756935 cites W1997810509 @default.
• W2808756935 cites W1998818726 @default.
• W2808756935 cites W2000837340 @default.
• W2808756935 cites W2003213153 @default.
• W2808756935 cites W2007342256 @default.
• W2808756935 cites W2020456228 @default.
• W2808756935 cites W2021371661 @default.
• W2808756935 cites W2024045774 @default.
• W2808756935 cites W2028194167 @default.
• W2808756935 cites W2031050297 @default.
• W2808756935 cites W2031799746 @default.
• W2808756935 cites W2039057018 @default.
• W2808756935 cites W2045805069 @default.
• W2808756935 cites W2055162328 @default.
• W2808756935 cites W2057734360 @default.
• W2808756935 cites W2067513456 @default.
• W2808756935 cites W2076136326 @default.
• W2808756935 cites W2077814106 @default.
• W2808756935 cites W2080229852 @default.
• W2808756935 cites W2083832224 @default.
• W2808756935 cites W2086939643 @default.
• W2808756935 cites W2093725917 @default.
• W2808756935 cites W2101634616 @default.
• W2808756935 cites W2113352126 @default.
• W2808756935 cites W2113581209 @default.
• W2808756935 cites W2113697838 @default.
• W2808756935 cites W2113949832 @default.
• W2808756935 cites W2114875470 @default.
• W2808756935 cites W2122303350 @default.
• W2808756935 cites W2124758627 @default.
• W2808756935 cites W2127686099 @default.
• W2808756935 cites W2137512902 @default.
• W2808756935 cites W2138767280 @default.
• W2808756935 cites W2139521250 @default.
• W2808756935 cites W2141312569 @default.
• W2808756935 cites W2148639087 @default.
• W2808756935 cites W2149049293 @default.
• W2808756935 cites W2150774373 @default.
• W2808756935 cites W2153711239 @default.
• W2808756935 cites W2155602568 @default.
• W2808756935 cites W2161962336 @default.
• W2808756935 cites W2167099022 @default.
• W2808756935 cites W2170686519 @default.
• W2808756935 cites W2170821394 @default.
• W2808756935 cites W2171709369 @default.
• W2808756935 cites W2195295268 @default.
• W2808756935 cites W2241843730 @default.
• W2808756935 cites W2252063010 @default.
• W2808756935 cites W2291522985 @default.
• W2808756935 cites W2332495596 @default.
• W2808756935 cites W2332736166 @default.
• W2808756935 cites W2343623791 @default.
• W2808756935 cites W2395612161 @default.
• W2808756935 cites W2396599501 @default.
• W2808756935 cites W2467566329 @default.
• W2808756935 cites W2528564885 @default.
• W2808756935 cites W2560609124 @default.
• W2808756935 cites W2580706718 @default.
• W2808756935 cites W2583987107 @default.
• W2808756935 cites W2596883961 @default.
• W2808756935 cites W2611825467 @default.
• W2808756935 cites W2612478849 @default.
• W2808756935 cites W2713361452 @default.
• W2808756935 cites W2721575552 @default.
• W2808756935 cites W2736840806 @default.
• W2808756935 cites W2739423598 @default.
• W2808756935 cites W4214942744 @default.
• W2808756935 cites W4235348522 @default.
• W2808756935 cites W4323966435 @default.
• W2808756935 cites W747422444 @default.
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• W2808756935 doi "https://doi.org/10.1016/j.breast.2018.06.013" @default.
• W2808756935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30007267" @default.

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