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- W2808789237 abstract "目的运用弱阳离子磁珠（magnetic beads based weak cation exchange, MB-WCX）联合基质辅助激光解吸离子飞行时间质谱（matrix assisted laser desorption ionization time of flight mass spectrometry, MALDI-TOF MS）建立结直肠癌血清蛋白组学诊断模型。 方法收集我院正常对照（健康体检者）、结直肠癌术前及术后患者血清标本各72例，弱阳离子磁珠分离血清多肽，MALDI-TOF MS建立正常对照、结直肠癌术前及术后患者血清蛋白表达谱，ClinProt Tools 2.0软件分析差异表达峰并建立诊断模型，液相色谱-电喷雾离子化质谱（liquid chromatography-eletronic spray ionization mass/mass, LC-ESI-MS/MS）鉴定差异表达蛋白。 结果对比分析正常对照、结直肠癌术前及术后血清蛋白图谱，共发现80个差异表达峰，12个峰差异具有统计学意义（均P 结论血清蛋白质谱模型能够准确区分正常对照与结直肠癌患者，但尚需更进一步研究证实。" @default.
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- W2808789237 date "2018-06-08" @default.
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- W2808789237 title "MB-WCX联合MALDI-TOF MS建立结直肠癌血清诊断模型" @default.
- W2808789237 doi "https://doi.org/10.3971/j.issn.1000-8578.2018.17.1276" @default.
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