FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808837692> ?p ?o ?g. }

• W2808837692 abstract "Abstract Osteoarthritis (OA) is a complex degenerative joint disorder, which is caused by both environmental and genetic factors. Previous studies have indicated that the GNL3 gene is associated with knee osteoarthritis (KOA) susceptibility in Europeans; however, the exact molecular mechanism is still unclear. In the present study, we investigated the potential genetic association of GNL3 with KOA in a two-stage sample of 6,704 individuals from the Han Chinese population. Subjects containing 1,052 KOA patients and 2,117 controls were considered the discovery dataset, while subjects consisting of 1,173 KOA patients and 2,362 controls were utilized as the replication dataset. Single-SNP association, imputation, and haplotypic association analyses were performed. The SNP of rs11177 in GNL3 was identified to be significantly associated with KOA after accounting for age, gender and BMI in both stages. The imputed SNP of rs6617 in SPCS1 was found to be strongly associated with KOA risk, and the significant association signal was confirmed in the replication stage. Moreover, a haplotype-based analysis also indicated a positive genetic effect of GNL3 on KOA susceptibility. In summary, our results proved that GNL3 plays an important role in the etiology of KOA, suggesting that GNL3 is a potential genetic modifier for KOA development." @default.
• W2808837692 created "2018-06-29" @default.
• W2808837692 creator A5000268131 @default.
• W2808837692 creator A5001928175 @default.
• W2808837692 creator A5009844753 @default.
• W2808837692 creator A5054325872 @default.
• W2808837692 creator A5076702481 @default.
• W2808837692 creator A5081292202 @default.
• W2808837692 creator A5090815103 @default.
• W2808837692 date "2018-06-25" @default.
• W2808837692 modified "2023-10-16" @default.
• W2808837692 title "Common variants in the GNL3 contribute to the increasing risk of knee osteoarthritis in Han Chinese population" @default.
• W2808837692 cites W1562897792 @default.
• W2808837692 cites W1859919406 @default.
• W2808837692 cites W1883415090 @default.
• W2808837692 cites W1913410150 @default.
• W2808837692 cites W1949757104 @default.
• W2808837692 cites W1969435202 @default.
• W2808837692 cites W1988508537 @default.
• W2808837692 cites W1989843183 @default.
• W2808837692 cites W1992282491 @default.
• W2808837692 cites W2008887939 @default.
• W2808837692 cites W2010054222 @default.
• W2808837692 cites W2059238175 @default.
• W2808837692 cites W2061115737 @default.
• W2808837692 cites W2062664473 @default.
• W2808837692 cites W2076631139 @default.
• W2808837692 cites W2089276164 @default.
• W2808837692 cites W2095737334 @default.
• W2808837692 cites W2113858336 @default.
• W2808837692 cites W2115588119 @default.
• W2808837692 cites W2140609232 @default.
• W2808837692 cites W2159837021 @default.
• W2808837692 cites W2160063494 @default.
• W2808837692 cites W2190285290 @default.
• W2808837692 cites W2333733892 @default.
• W2808837692 cites W2341972066 @default.
• W2808837692 cites W2416886523 @default.
• W2808837692 cites W2469993515 @default.
• W2808837692 cites W2475363254 @default.
• W2808837692 cites W2508728551 @default.
• W2808837692 cites W2557263742 @default.
• W2808837692 cites W2591076406 @default.
• W2808837692 cites W4249798376 @default.
• W2808837692 doi "https://doi.org/10.1038/s41598-018-27971-4" @default.
• W2808837692 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6018215" @default.
• W2808837692 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29942097" @default.
• W2808837692 hasPublicationYear "2018" @default.
• W2808837692 type Work @default.
• W2808837692 sameAs 2808837692 @default.
• W2808837692 citedByCount "6" @default.
• W2808837692 countsByYear W28088376922019 @default.
• W2808837692 countsByYear W28088376922020 @default.
• W2808837692 countsByYear W28088376922021 @default.
• W2808837692 countsByYear W28088376922022 @default.
• W2808837692 countsByYear W28088376922023 @default.
• W2808837692 crossrefType "journal-article" @default.
• W2808837692 hasAuthorship W2808837692A5000268131 @default.
• W2808837692 hasAuthorship W2808837692A5001928175 @default.
• W2808837692 hasAuthorship W2808837692A5009844753 @default.
• W2808837692 hasAuthorship W2808837692A5054325872 @default.
• W2808837692 hasAuthorship W2808837692A5076702481 @default.
• W2808837692 hasAuthorship W2808837692A5081292202 @default.
• W2808837692 hasAuthorship W2808837692A5090815103 @default.
• W2808837692 hasBestOaLocation W28088376921 @default.
• W2808837692 hasConcept C104317684 @default.
• W2808837692 hasConcept C119857082 @default.
• W2808837692 hasConcept C126322002 @default.
• W2808837692 hasConcept C135763542 @default.
• W2808837692 hasConcept C137627325 @default.
• W2808837692 hasConcept C139275648 @default.
• W2808837692 hasConcept C142724271 @default.
• W2808837692 hasConcept C153209595 @default.
• W2808837692 hasConcept C186413461 @default.
• W2808837692 hasConcept C197754878 @default.
• W2808837692 hasConcept C204787440 @default.
• W2808837692 hasConcept C2776164576 @default.
• W2808837692 hasConcept C2908647359 @default.
• W2808837692 hasConcept C41008148 @default.
• W2808837692 hasConcept C54355233 @default.
• W2808837692 hasConcept C58041806 @default.
• W2808837692 hasConcept C60644358 @default.
• W2808837692 hasConcept C67636389 @default.
• W2808837692 hasConcept C71924100 @default.
• W2808837692 hasConcept C86803240 @default.
• W2808837692 hasConcept C9357733 @default.
• W2808837692 hasConcept C99454951 @default.
• W2808837692 hasConceptScore W2808837692C104317684 @default.
• W2808837692 hasConceptScore W2808837692C119857082 @default.
• W2808837692 hasConceptScore W2808837692C126322002 @default.
• W2808837692 hasConceptScore W2808837692C135763542 @default.
• W2808837692 hasConceptScore W2808837692C137627325 @default.
• W2808837692 hasConceptScore W2808837692C139275648 @default.
• W2808837692 hasConceptScore W2808837692C142724271 @default.
• W2808837692 hasConceptScore W2808837692C153209595 @default.
• W2808837692 hasConceptScore W2808837692C186413461 @default.
• W2808837692 hasConceptScore W2808837692C197754878 @default.
• W2808837692 hasConceptScore W2808837692C204787440 @default.
• W2808837692 hasConceptScore W2808837692C2776164576 @default.
• W2808837692 hasConceptScore W2808837692C2908647359 @default.

• next