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• W2808839071 abstract "There is increasing evidence that microRNAs (miRNAs) play important roles in tumor progression and development by targeting different genes, including gastric cancer (GC). However, the role of miR-16 in GC is so far unclear. Herein, we examined the function and potential mechanism of miR-16 in GC. Reverse transcription-quantitative PCR found that miR-16 expression was prominently lower in GC tissues while SALL4 expression was frequently higher than normal tissues. Re-expression of miR-16 could suppress GC cell proliferation and migration by MTT and Transwell assay. We confirmed that miR-16 directly targeted SALL4 in regulating GC by luciferase assay. Knockdown of SALL4 inhibited cell proliferation and migration. Furthermore, SALL4 could counteract the inhibition-effect of miR-16 in GC. In conclusion, for the the first time we demonstrated that miR-16 played inhibitory effect through targeting SALL4 in GC cell proliferation and migration. Our study revealed that miR-16/SALL4 axis was critical in regulating the GC development, indicating a new prospect to regulate GC cell progression and development." @default.
• W2808839071 created "2018-06-29" @default.
• W2808839071 creator A5018616951 @default.
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• W2808839071 date "2018-06-20" @default.
• W2808839071 modified "2023-09-25" @default.
• W2808839071 title "miR-16 targets SALL4 to repress the proliferation and migration of gastric cancer" @default.
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• W2808839071 doi "https://doi.org/10.3892/ol.2018.8997" @default.
• W2808839071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6096186" @default.
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