FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808843507> ?p ?o ?g. }

• W2808843507 abstract "Changes of serum concentrations of glycated, oxidized, and nitrated amino acids and hydroxyproline and anticyclic citrullinated peptide antibody status combined by machine learning techniques in algorithms have recently been found to provide improved diagnosis and typing of early-stage arthritis of the knee, including osteoarthritis (OA), in patients. The association of glycated, oxidized, and nitrated amino acids released from the joint with development and progression of knee OA is unknown. We studied this in an OA animal model as well as interleukin-1β-activated human chondrocytes in vitro and translated key findings to patients with OA.Sixty male 3-week-old Dunkin-Hartley guinea pigs were studied. Separate groups of 12 animals were killed at age 4, 12, 20, 28 and 36 weeks, and histological severity of knee OA was evaluated, and cartilage rheological properties were assessed. Human chondrocytes cultured in multilayers were treated for 10 days with interleukin-1β. Human patients with early and advanced OA and healthy controls were recruited, blood samples were collected, and serum or plasma was prepared. Serum, plasma, and culture medium were analyzed for glycated, oxidized, and nitrated amino acids.Severity of OA increased progressively in guinea pigs with age. Glycated, oxidized, and nitrated amino acids were increased markedly at week 36, with glucosepane and dityrosine increasing progressively from weeks 20 and 28, respectively. Glucosepane correlated positively with OA histological severity (r = 0.58, p < 0.0001) and instantaneous modulus (r = 0.52-0.56; p < 0.0001), oxidation free adducts correlated positively with OA severity (p < 0.0009-0.0062), and hydroxyproline correlated positively with cartilage thickness (p < 0.0003-0.003). Interleukin-1β increased the release of glycated and nitrated amino acids from chondrocytes in vitro. In clinical translation, plasma glucosepane was increased 38% in early-stage OA (p < 0.05) and sixfold in patients with advanced OA (p < 0.001) compared with healthy controls.These studies further advance the prospective role of glycated, oxidized, and nitrated amino acids as serum biomarkers in diagnostic algorithms for early-stage detection of OA and other arthritic disease. Plasma glucosepane, reported here for the first time to our knowledge, may improve early-stage diagnosis and progression of clinical OA." @default.
• W2808843507 created "2018-06-29" @default.
• W2808843507 creator A5011604444 @default.
• W2808843507 creator A5012454701 @default.
• W2808843507 creator A5021086938 @default.
• W2808843507 creator A5033477058 @default.
• W2808843507 creator A5039781359 @default.
• W2808843507 creator A5056708838 @default.
• W2808843507 creator A5060205873 @default.
• W2808843507 creator A5071196909 @default.
• W2808843507 creator A5073408581 @default.
• W2808843507 creator A5085934383 @default.
• W2808843507 creator A5090583139 @default.
• W2808843507 date "2018-06-22" @default.
• W2808843507 modified "2023-10-05" @default.
• W2808843507 title "Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo" @default.
• W2808843507 cites W1749441934 @default.
• W2808843507 cites W178991289 @default.
• W2808843507 cites W1943190408 @default.
• W2808843507 cites W1961648612 @default.
• W2808843507 cites W1968946402 @default.
• W2808843507 cites W1978454670 @default.
• W2808843507 cites W1988436413 @default.
• W2808843507 cites W1992252990 @default.
• W2808843507 cites W1992850373 @default.
• W2808843507 cites W1996920770 @default.
• W2808843507 cites W2002144258 @default.
• W2808843507 cites W2002780234 @default.
• W2808843507 cites W2009305147 @default.
• W2808843507 cites W2010899799 @default.
• W2808843507 cites W2011443409 @default.
• W2808843507 cites W2018999183 @default.
• W2808843507 cites W2033765991 @default.
• W2808843507 cites W2044775219 @default.
• W2808843507 cites W2045372182 @default.
• W2808843507 cites W2058435889 @default.
• W2808843507 cites W2059670411 @default.
• W2808843507 cites W2071540582 @default.
• W2808843507 cites W2085100495 @default.
• W2808843507 cites W2087543260 @default.
• W2808843507 cites W2094420410 @default.
• W2808843507 cites W2096734017 @default.
• W2808843507 cites W2104787607 @default.
• W2808843507 cites W2107524932 @default.
• W2808843507 cites W2124853228 @default.
• W2808843507 cites W2128468094 @default.
• W2808843507 cites W2129531706 @default.
• W2808843507 cites W2131130971 @default.
• W2808843507 cites W2136261717 @default.
• W2808843507 cites W2152348310 @default.
• W2808843507 cites W2171861146 @default.
• W2808843507 cites W2205207837 @default.
• W2808843507 cites W2269139557 @default.
• W2808843507 cites W2391680777 @default.
• W2808843507 cites W2411416582 @default.
• W2808843507 cites W2432892462 @default.
• W2808843507 cites W2513956585 @default.
• W2808843507 cites W2540445000 @default.
• W2808843507 cites W2624406620 @default.
• W2808843507 cites W284783631 @default.
• W2808843507 cites W4211003135 @default.
• W2808843507 cites W4312314171 @default.
• W2808843507 doi "https://doi.org/10.1186/s13075-018-1636-6" @default.
• W2808843507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6013878" @default.
• W2808843507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29929535" @default.
• W2808843507 hasPublicationYear "2018" @default.
• W2808843507 type Work @default.
• W2808843507 sameAs 2808843507 @default.
• W2808843507 citedByCount "15" @default.
• W2808843507 countsByYear W28088435072019 @default.
• W2808843507 countsByYear W28088435072020 @default.
• W2808843507 countsByYear W28088435072021 @default.
• W2808843507 countsByYear W28088435072022 @default.
• W2808843507 crossrefType "journal-article" @default.
• W2808843507 hasAuthorship W2808843507A5011604444 @default.
• W2808843507 hasAuthorship W2808843507A5012454701 @default.
• W2808843507 hasAuthorship W2808843507A5021086938 @default.
• W2808843507 hasAuthorship W2808843507A5033477058 @default.
• W2808843507 hasAuthorship W2808843507A5039781359 @default.
• W2808843507 hasAuthorship W2808843507A5056708838 @default.
• W2808843507 hasAuthorship W2808843507A5060205873 @default.
• W2808843507 hasAuthorship W2808843507A5071196909 @default.
• W2808843507 hasAuthorship W2808843507A5073408581 @default.
• W2808843507 hasAuthorship W2808843507A5085934383 @default.
• W2808843507 hasAuthorship W2808843507A5090583139 @default.
• W2808843507 hasBestOaLocation W28088435071 @default.
• W2808843507 hasConcept C105702510 @default.
• W2808843507 hasConcept C126322002 @default.
• W2808843507 hasConcept C134018914 @default.
• W2808843507 hasConcept C142724271 @default.
• W2808843507 hasConcept C147990577 @default.
• W2808843507 hasConcept C150903083 @default.
• W2808843507 hasConcept C185592680 @default.
• W2808843507 hasConcept C198451711 @default.
• W2808843507 hasConcept C203014093 @default.
• W2808843507 hasConcept C204787440 @default.
• W2808843507 hasConcept C207001950 @default.
• W2808843507 hasConcept C2776164576 @default.
• W2808843507 hasConcept C2777077863 @default.
• W2808843507 hasConcept C2780550940 @default.

• next