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- W2808983734 abstract "Naked mole rats (NMRs, Heterocephalus glaber) are long-lived, cancer-resistant rodents. Here, we report the development of an induced pluripotent stem cell (iPSC) line generated from immortalized NMR embryonic fibroblasts transduced with a doxycycline-inducible mouse OSKM polycistronic vector. This iPSC line was shown to express pluripotency-associated markers, form embryoid bodies, differentiate in vitro to the derivatives of three germ layers, and exhibit normal karyotype. The ability of iPSCs to differentiate in vivo was supported by the contribution to interspecific chimera upon injection into mouse blastocysts. This NMR iPSC line may be a useful tool in cancer and aging research." @default.
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- W2808983734 date "2018-08-01" @default.
- W2808983734 modified "2023-10-17" @default.
- W2808983734 title "A naked mole rat iPSC line expressing drug-inducible mouse pluripotency factors developed from embryonic fibroblasts" @default.
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- W2808983734 doi "https://doi.org/10.1016/j.scr.2018.06.010" @default.
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