FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808994189> ?p ?o ?g. }

• W2808994189 endingPage "167" @default.
• W2808994189 startingPage "164" @default.
• W2808994189 abstract "Genome-wide association study (GWAS) in Icelanders identified HLA class II sequence variants on chromosome 6p21 as tuberculosis (TB) susceptibility loci. To evaluate the role of these loci in other populations with different ancestry, we conducted a case-control study in Chinese population.We genotyped two genetic variants (rs9272461 and rs9271300) on the reported chromosome 6p21 in 739 pulmonary tuberculosis (PTB) cases and 749 healthy controls from Chinese Han population using TaqMan allelic discrimination assay. Logistic regression was applied to evaluate the association between genetic variants and PTB risk and to estimate corresponding odds ratios (ORs) and 95% confidence intervals (95%CIs).We found that rs9272461 was significantly associated with the risk of PTB in various genetic models (dominant OR = 0.75, 95%CI: 0.61-0.92; recessive OR = 0.64, 95%CI: 0.46-0.90, and additive OR = 0.78, 95%CI: 0.67-0.90). Moreover, in the stratified analysis in additive model, the association was also significant in the old (age ≥ 48 years) (OR = 0.76, 95%CI: 0.62-0.93; P = .008), men (OR = 0.71, 95%CI: 0.59-0.85; P < .001), and new PTB cases (OR = 0.76, 95%CI: 0.65-0.90; P = .001). The association results were similar between the microbiologically negative (OR = 0.78, 95%CI: 0.64-0.94; P = .008) and positive cases (OR = 0.77, 95%CI: 0.64-0.93; P = .008). We did not observe significant association for rs9271300 neither in the overall analysis (additive model: OR = 0.98, 95%CI: 0.85-1.13; P = .776) nor in the stratified analysis.Our findings indicate that the HLA class II locus also affects the susceptibility to PTB in Chinese population. Further validation studies and function experiments are required to confirm the roles of the discovered variant." @default.
• W2808994189 created "2018-06-29" @default.
• W2808994189 creator A5004483141 @default.
• W2808994189 creator A5028628100 @default.
• W2808994189 creator A5032447166 @default.
• W2808994189 creator A5048324326 @default.
• W2808994189 creator A5054599738 @default.
• W2808994189 creator A5056423626 @default.
• W2808994189 creator A5060231857 @default.
• W2808994189 creator A5068291954 @default.
• W2808994189 creator A5069445164 @default.
• W2808994189 date "2018-10-01" @default.
• W2808994189 modified "2023-10-18" @default.
• W2808994189 title "An HLA class II locus, previously identified by a genome-wide association study, is also associated with susceptibility to pulmonary tuberculosis in a Chinese population" @default.
• W2808994189 cites W1992890129 @default.
• W2808994189 cites W2007250728 @default.
• W2808994189 cites W2015177444 @default.
• W2808994189 cites W2026014108 @default.
• W2808994189 cites W2030704316 @default.
• W2808994189 cites W2055577456 @default.
• W2808994189 cites W2080896009 @default.
• W2808994189 cites W2085104810 @default.
• W2808994189 cites W2148568906 @default.
• W2808994189 cites W2166593999 @default.
• W2808994189 cites W2265174853 @default.
• W2808994189 cites W2294059140 @default.
• W2808994189 cites W2418023999 @default.
• W2808994189 cites W2419637322 @default.
• W2808994189 cites W2467509831 @default.
• W2808994189 cites W2471766627 @default.
• W2808994189 cites W2732085233 @default.
• W2808994189 doi "https://doi.org/10.1016/j.meegid.2018.06.022" @default.
• W2808994189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29933081" @default.
• W2808994189 hasPublicationYear "2018" @default.
• W2808994189 type Work @default.
• W2808994189 sameAs 2808994189 @default.
• W2808994189 citedByCount "5" @default.
• W2808994189 countsByYear W28089941892019 @default.
• W2808994189 countsByYear W28089941892020 @default.
• W2808994189 countsByYear W28089941892022 @default.
• W2808994189 crossrefType "journal-article" @default.
• W2808994189 hasAuthorship W2808994189A5004483141 @default.
• W2808994189 hasAuthorship W2808994189A5028628100 @default.
• W2808994189 hasAuthorship W2808994189A5032447166 @default.
• W2808994189 hasAuthorship W2808994189A5048324326 @default.
• W2808994189 hasAuthorship W2808994189A5054599738 @default.
• W2808994189 hasAuthorship W2808994189A5056423626 @default.
• W2808994189 hasAuthorship W2808994189A5060231857 @default.
• W2808994189 hasAuthorship W2808994189A5068291954 @default.
• W2808994189 hasAuthorship W2808994189A5069445164 @default.
• W2808994189 hasConcept C104317684 @default.
• W2808994189 hasConcept C106208931 @default.
• W2808994189 hasConcept C126322002 @default.
• W2808994189 hasConcept C135763542 @default.
• W2808994189 hasConcept C142724271 @default.
• W2808994189 hasConcept C146304588 @default.
• W2808994189 hasConcept C147483822 @default.
• W2808994189 hasConcept C151956035 @default.
• W2808994189 hasConcept C153209595 @default.
• W2808994189 hasConcept C156957248 @default.
• W2808994189 hasConcept C180754005 @default.
• W2808994189 hasConcept C186413461 @default.
• W2808994189 hasConcept C188280979 @default.
• W2808994189 hasConcept C203014093 @default.
• W2808994189 hasConcept C2781069245 @default.
• W2808994189 hasConcept C2908647359 @default.
• W2808994189 hasConcept C2992519594 @default.
• W2808994189 hasConcept C44249647 @default.
• W2808994189 hasConcept C54355233 @default.
• W2808994189 hasConcept C71924100 @default.
• W2808994189 hasConcept C84597430 @default.
• W2808994189 hasConcept C86803240 @default.
• W2808994189 hasConcept C99454951 @default.
• W2808994189 hasConceptScore W2808994189C104317684 @default.
• W2808994189 hasConceptScore W2808994189C106208931 @default.
• W2808994189 hasConceptScore W2808994189C126322002 @default.
• W2808994189 hasConceptScore W2808994189C135763542 @default.
• W2808994189 hasConceptScore W2808994189C142724271 @default.
• W2808994189 hasConceptScore W2808994189C146304588 @default.
• W2808994189 hasConceptScore W2808994189C147483822 @default.
• W2808994189 hasConceptScore W2808994189C151956035 @default.
• W2808994189 hasConceptScore W2808994189C153209595 @default.
• W2808994189 hasConceptScore W2808994189C156957248 @default.
• W2808994189 hasConceptScore W2808994189C180754005 @default.
• W2808994189 hasConceptScore W2808994189C186413461 @default.
• W2808994189 hasConceptScore W2808994189C188280979 @default.
• W2808994189 hasConceptScore W2808994189C203014093 @default.
• W2808994189 hasConceptScore W2808994189C2781069245 @default.
• W2808994189 hasConceptScore W2808994189C2908647359 @default.
• W2808994189 hasConceptScore W2808994189C2992519594 @default.
• W2808994189 hasConceptScore W2808994189C44249647 @default.
• W2808994189 hasConceptScore W2808994189C54355233 @default.
• W2808994189 hasConceptScore W2808994189C71924100 @default.
• W2808994189 hasConceptScore W2808994189C84597430 @default.
• W2808994189 hasConceptScore W2808994189C86803240 @default.
• W2808994189 hasConceptScore W2808994189C99454951 @default.
• W2808994189 hasLocation W28089941891 @default.
• W2808994189 hasLocation W28089941892 @default.

• next