Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809025653> ?p ?o ?g. }
- W2809025653 endingPage "1367" @default.
- W2809025653 startingPage "1362" @default.
- W2809025653 abstract "Aim Hepcidin is a central regulator of iron homeostasis. Its production is also influenced by systemic inflammation. The aims of this study were to compare hepcidin levels in paediatric patients newly diagnosed with Crohn's disease (CD) and ulcerative colitis (UC) and to determine the association of hepcidin levels with laboratory and clinical parameters of inflammatory bowel disease (IBD) activity. Methods Children with newly diagnosed IBD between January 2012 and September 2016 were enrolled in this comparative cross‐sectional study. We analysed levels of serum hepcidin, C‐reactive protein, iron, ferritin, soluble transferrin receptors, blood count and faecal calprotectin in all subjects. Serum hepcidin levels were measured by reverse‐phase liquid chromatography. The Paediatric Crohn's Disease Activity Index was used to evaluate CD in children, and Paediatric Ulcerative Colitis Activity Index was used for the assessment of UC disease activity. Results Subjects with CD ( n = 53) had significantly higher serum hepcidin levels compared with subjects with UC ( n = 23) – 22.6 ng/mL (range 8.5–65.0) versus 6.5 ng/mL (range 2.4–25.8) ( P < 0.05). Hepcidin was independently associated with ferritin levels in all IBD patients ( P < 0.05). Moreover, there was a significant positive correlation between hepcidin and platelet count ( P < 0.05) in children with CD and a negative correlation between hepcidin and faecal calprotectin ( P < 0.05) in children with UC. Conclusion Different hepcidin levels between children with newly diagnosed CD and UC suggest the distinct contribution of iron deficiency and/or systemic inflammation to anaemia and may help clinicians choose the best anti‐anaemic treatment." @default.
- W2809025653 created "2018-06-29" @default.
- W2809025653 creator A5017470886 @default.
- W2809025653 creator A5022508239 @default.
- W2809025653 creator A5048908948 @default.
- W2809025653 creator A5055464838 @default.
- W2809025653 creator A5071253203 @default.
- W2809025653 creator A5074559351 @default.
- W2809025653 creator A5075977394 @default.
- W2809025653 creator A5085991301 @default.
- W2809025653 date "2018-06-20" @default.
- W2809025653 modified "2023-09-27" @default.
- W2809025653 title "Hepcidin in newly diagnosed inflammatory bowel disease in children" @default.
- W2809025653 cites W1595284826 @default.
- W2809025653 cites W1595296968 @default.
- W2809025653 cites W1924847619 @default.
- W2809025653 cites W1984922769 @default.
- W2809025653 cites W2001242767 @default.
- W2809025653 cites W2006579028 @default.
- W2809025653 cites W2010940655 @default.
- W2809025653 cites W2016239788 @default.
- W2809025653 cites W2016920824 @default.
- W2809025653 cites W2020461096 @default.
- W2809025653 cites W2021053299 @default.
- W2809025653 cites W2027624389 @default.
- W2809025653 cites W2029565279 @default.
- W2809025653 cites W2037674164 @default.
- W2809025653 cites W2042149448 @default.
- W2809025653 cites W2044466822 @default.
- W2809025653 cites W2046291329 @default.
- W2809025653 cites W2068938145 @default.
- W2809025653 cites W2079732985 @default.
- W2809025653 cites W2086398642 @default.
- W2809025653 cites W2093340986 @default.
- W2809025653 cites W2115797209 @default.
- W2809025653 cites W2121300659 @default.
- W2809025653 cites W2124903183 @default.
- W2809025653 cites W2139324545 @default.
- W2809025653 cites W2144472014 @default.
- W2809025653 cites W2147372244 @default.
- W2809025653 cites W2160011929 @default.
- W2809025653 cites W2160035970 @default.
- W2809025653 cites W2163447382 @default.
- W2809025653 cites W2232323550 @default.
- W2809025653 cites W2316368001 @default.
- W2809025653 cites W2354459017 @default.
- W2809025653 cites W2758466320 @default.
- W2809025653 doi "https://doi.org/10.1111/jpc.14093" @default.
- W2809025653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29923651" @default.
- W2809025653 hasPublicationYear "2018" @default.
- W2809025653 type Work @default.
- W2809025653 sameAs 2809025653 @default.
- W2809025653 citedByCount "11" @default.
- W2809025653 countsByYear W28090256532019 @default.
- W2809025653 countsByYear W28090256532020 @default.
- W2809025653 countsByYear W28090256532021 @default.
- W2809025653 countsByYear W28090256532022 @default.
- W2809025653 countsByYear W28090256532023 @default.
- W2809025653 crossrefType "journal-article" @default.
- W2809025653 hasAuthorship W2809025653A5017470886 @default.
- W2809025653 hasAuthorship W2809025653A5022508239 @default.
- W2809025653 hasAuthorship W2809025653A5048908948 @default.
- W2809025653 hasAuthorship W2809025653A5055464838 @default.
- W2809025653 hasAuthorship W2809025653A5071253203 @default.
- W2809025653 hasAuthorship W2809025653A5074559351 @default.
- W2809025653 hasAuthorship W2809025653A5075977394 @default.
- W2809025653 hasAuthorship W2809025653A5085991301 @default.
- W2809025653 hasConcept C126322002 @default.
- W2809025653 hasConcept C203014093 @default.
- W2809025653 hasConcept C2776768029 @default.
- W2809025653 hasConcept C2776914184 @default.
- W2809025653 hasConcept C2778260677 @default.
- W2809025653 hasConcept C2778292693 @default.
- W2809025653 hasConcept C2778319317 @default.
- W2809025653 hasConcept C2779008522 @default.
- W2809025653 hasConcept C2779134260 @default.
- W2809025653 hasConcept C2780479503 @default.
- W2809025653 hasConcept C57194454 @default.
- W2809025653 hasConcept C71924100 @default.
- W2809025653 hasConcept C90924648 @default.
- W2809025653 hasConceptScore W2809025653C126322002 @default.
- W2809025653 hasConceptScore W2809025653C203014093 @default.
- W2809025653 hasConceptScore W2809025653C2776768029 @default.
- W2809025653 hasConceptScore W2809025653C2776914184 @default.
- W2809025653 hasConceptScore W2809025653C2778260677 @default.
- W2809025653 hasConceptScore W2809025653C2778292693 @default.
- W2809025653 hasConceptScore W2809025653C2778319317 @default.
- W2809025653 hasConceptScore W2809025653C2779008522 @default.
- W2809025653 hasConceptScore W2809025653C2779134260 @default.
- W2809025653 hasConceptScore W2809025653C2780479503 @default.
- W2809025653 hasConceptScore W2809025653C57194454 @default.
- W2809025653 hasConceptScore W2809025653C71924100 @default.
- W2809025653 hasConceptScore W2809025653C90924648 @default.
- W2809025653 hasFunder F4320321006 @default.
- W2809025653 hasIssue "12" @default.
- W2809025653 hasLocation W28090256531 @default.
- W2809025653 hasLocation W28090256532 @default.
- W2809025653 hasOpenAccess W2809025653 @default.