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- W2809040487 abstract "Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) is a natural circulating inhibitor of the LDL receptor. There is evidence that PCSK9 is a risk factor for coronary artery disease. In this study we aimed to determine factors associated with PCSK9 in patients with DMt2, according to statin treatment. Material included 116 consecutive patients with DMt2. Fasting serum lipids were determined enzymatically, apolipoproteins B100, A1 by immunoturbidimetry, apo C3, B48, pentraxin 3 (PTX3) and PCSK9 by ELISA, glycated hemoglobin A1c by HPLC. In the examined group 67 persons were statins users. Mean (SD) age of patients was 59.1 (11.1) years, HbA1c 8.6 (2.4%). Mean (SD) values of serum LDL-cholesterol were 2.6 (1.16) mmol/l and of serum PCSK9 255,4 (106,97) ng/ml. Patients treated with statins were older and had lower LDL-C: 2.38 (1.1) vs. 2.96 (1.2) mmol/l, p Disclosure M. Walus-Miarka: None. M. Kapusta: None. E. Kawalec: None. B. Idzior-Walus: None." @default.
- W2809040487 created "2018-06-29" @default.
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- W2809040487 date "2018-06-22" @default.
- W2809040487 modified "2023-09-25" @default.
- W2809040487 title "Circulating PCSK9 in Statin-Treated Patients with Type 2 Diabetes Mellitus (T2DM)" @default.
- W2809040487 doi "https://doi.org/10.2337/db18-2217-pub" @default.
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