Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809054311> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2809054311 endingPage "400" @default.
- W2809054311 startingPage "398" @default.
- W2809054311 abstract "While the long-term administration of antipsychotics is known to cause dopamine supersensitivity psychosis (DSP), recent studies revealed that DSP helps form the foundation of treatment resistance. Electroconvulsive shock (ES) is one of the more effective treatments for treatment-resistant schizophrenia. The objective of this study was to examine whether repeated ES can release rats from dopamine supersensitivity states such as striatal dopamine D2 receptor (DRD2) up-regulation and voluntary hyperlocomotion following chronic administration of haloperidol (HAL). HAL (0.75 mg/kg/day) was administered for 14 days via mini-pumps implanted in rats, and DRD2 density and voluntary locomotion were measured one day after drug cessation to confirm the development of dopamine supersensitivity. The rats with or without dopamine supersensitivity received repeated ES or sham treatments, and then DRD2 density was assessed and a voluntary locomotion test was performed. Chronic treatment with HAL led to the up-regulation of striatal DRD2 and hyperlocomotion in the rats one day after drug cessation. We thus confirmed that these rats experienced a dopamine supersensitivity state. Moreover, after repeated ES, locomotor activity and DRD2 density in the DSP model rats fell to the control level, while an ES sham operation had no effect on the dopamine supersensitivity state. The present study suggests that repeated ES could release DSP model rats from dopamine supersensitivity states. ES may be helpful for patients with DSP." @default.
- W2809054311 created "2018-06-29" @default.
- W2809054311 creator A5007678575 @default.
- W2809054311 creator A5032293493 @default.
- W2809054311 creator A5033793584 @default.
- W2809054311 creator A5048221957 @default.
- W2809054311 creator A5064662913 @default.
- W2809054311 date "2018-12-01" @default.
- W2809054311 modified "2023-09-30" @default.
- W2809054311 title "Combination therapy of electroconvulsive therapy and aripiprazole for dopamine supersensitivity psychosis" @default.
- W2809054311 cites W1503976483 @default.
- W2809054311 cites W2002943255 @default.
- W2809054311 cites W2081178081 @default.
- W2809054311 cites W2150602432 @default.
- W2809054311 cites W2154296992 @default.
- W2809054311 cites W2168180171 @default.
- W2809054311 cites W2234545454 @default.
- W2809054311 cites W2701376032 @default.
- W2809054311 cites W2758873794 @default.
- W2809054311 doi "https://doi.org/10.1016/j.schres.2018.06.038" @default.
- W2809054311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29937327" @default.
- W2809054311 hasPublicationYear "2018" @default.
- W2809054311 type Work @default.
- W2809054311 sameAs 2809054311 @default.
- W2809054311 citedByCount "6" @default.
- W2809054311 countsByYear W28090543112020 @default.
- W2809054311 countsByYear W28090543112021 @default.
- W2809054311 countsByYear W28090543112022 @default.
- W2809054311 countsByYear W28090543112023 @default.
- W2809054311 crossrefType "journal-article" @default.
- W2809054311 hasAuthorship W2809054311A5007678575 @default.
- W2809054311 hasAuthorship W2809054311A5032293493 @default.
- W2809054311 hasAuthorship W2809054311A5033793584 @default.
- W2809054311 hasAuthorship W2809054311A5048221957 @default.
- W2809054311 hasAuthorship W2809054311A5064662913 @default.
- W2809054311 hasConcept C118552586 @default.
- W2809054311 hasConcept C120069818 @default.
- W2809054311 hasConcept C126322002 @default.
- W2809054311 hasConcept C15744967 @default.
- W2809054311 hasConcept C2776412080 @default.
- W2809054311 hasConcept C2779727114 @default.
- W2809054311 hasConcept C2780211496 @default.
- W2809054311 hasConcept C2780948584 @default.
- W2809054311 hasConcept C44208683 @default.
- W2809054311 hasConcept C513476851 @default.
- W2809054311 hasConcept C71924100 @default.
- W2809054311 hasConcept C98274493 @default.
- W2809054311 hasConceptScore W2809054311C118552586 @default.
- W2809054311 hasConceptScore W2809054311C120069818 @default.
- W2809054311 hasConceptScore W2809054311C126322002 @default.
- W2809054311 hasConceptScore W2809054311C15744967 @default.
- W2809054311 hasConceptScore W2809054311C2776412080 @default.
- W2809054311 hasConceptScore W2809054311C2779727114 @default.
- W2809054311 hasConceptScore W2809054311C2780211496 @default.
- W2809054311 hasConceptScore W2809054311C2780948584 @default.
- W2809054311 hasConceptScore W2809054311C44208683 @default.
- W2809054311 hasConceptScore W2809054311C513476851 @default.
- W2809054311 hasConceptScore W2809054311C71924100 @default.
- W2809054311 hasConceptScore W2809054311C98274493 @default.
- W2809054311 hasLocation W28090543111 @default.
- W2809054311 hasLocation W28090543112 @default.
- W2809054311 hasOpenAccess W2809054311 @default.
- W2809054311 hasPrimaryLocation W28090543111 @default.
- W2809054311 hasRelatedWork W1990355158 @default.
- W2809054311 hasRelatedWork W2002689986 @default.
- W2809054311 hasRelatedWork W2011477540 @default.
- W2809054311 hasRelatedWork W2041632039 @default.
- W2809054311 hasRelatedWork W2140223605 @default.
- W2809054311 hasRelatedWork W2255883432 @default.
- W2809054311 hasRelatedWork W2271303358 @default.
- W2809054311 hasRelatedWork W2437422930 @default.
- W2809054311 hasRelatedWork W4235120786 @default.
- W2809054311 hasRelatedWork W4362734134 @default.
- W2809054311 hasVolume "202" @default.
- W2809054311 isParatext "false" @default.
- W2809054311 isRetracted "false" @default.
- W2809054311 magId "2809054311" @default.
- W2809054311 workType "article" @default.