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- W2809125364 endingPage "29" @default.
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- W2809125364 abstract "Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating and lethal neurodegenerative diseases seen comorbidly in up to 15% of patients. Despite several decades of research, no effective treatment or disease-modifying strategies have been developed. We now understand more than before about the genetics and biology behind ALS and FTD, but the genetic etiology for the majority of patients is still unknown and the phenotypic variability observed across patients, even those carrying the same mutation, is enigmatic. Additionally, susceptibility factors leading to neuronal vulnerability in specific central nervous system regions involved in disease are yet to be identified. As the inherited but dynamic epigenome acts as a cell-specific interface between the inherited fixed genome and both cell-intrinsic mechanisms and environmental input, adaptive epigenetic changes might contribute to the ALS/FTD aspects we still struggle to comprehend. This chapter summarizes our current understanding of basic epigenetic mechanisms, how they relate to ALS and FTD, and their potential as therapeutic targets. A clear understanding of the biological mechanisms driving these two currently incurable diseases is urgent-well-needed therapeutic strategies need to be developed soon. Disease-specific epigenetic changes have already been observed in patients and these might be central to this endeavor." @default.
- W2809125364 created "2018-06-29" @default.
- W2809125364 creator A5012880398 @default.
- W2809125364 creator A5040177206 @default.
- W2809125364 creator A5040220531 @default.
- W2809125364 date "2018-01-01" @default.
- W2809125364 modified "2023-09-23" @default.
- W2809125364 title "An Epigenetic Spin to ALS and FTD" @default.
- W2809125364 cites W1487070667 @default.
- W2809125364 cites W1511534554 @default.
- W2809125364 cites W1519160353 @default.
- W2809125364 cites W1527534059 @default.
- W2809125364 cites W1580690188 @default.
- W2809125364 cites W1610732998 @default.
- W2809125364 cites W1789457561 @default.
- W2809125364 cites W1941480039 @default.
- W2809125364 cites W1958676502 @default.
- W2809125364 cites W1966315727 @default.
- W2809125364 cites W1970091573 @default.
- W2809125364 cites W1970508468 @default.
- W2809125364 cites W1971131806 @default.
- W2809125364 cites W1974047233 @default.
- W2809125364 cites W1974134624 @default.
- W2809125364 cites W1974181990 @default.
- W2809125364 cites W1978901723 @default.
- W2809125364 cites W1982725145 @default.
- W2809125364 cites W1987105053 @default.
- W2809125364 cites W1987243580 @default.
- W2809125364 cites W1988163167 @default.
- W2809125364 cites W1988498229 @default.
- W2809125364 cites W1989322210 @default.
- W2809125364 cites W1991869354 @default.
- W2809125364 cites W1992065280 @default.
- W2809125364 cites W1993967927 @default.
- W2809125364 cites W1995100225 @default.
- W2809125364 cites W1998006860 @default.
- W2809125364 cites W1998102288 @default.
- W2809125364 cites W1999746344 @default.
- W2809125364 cites W1999808854 @default.
- W2809125364 cites W2001811842 @default.
- W2809125364 cites W2002407852 @default.
- W2809125364 cites W2003618511 @default.
- W2809125364 cites W2004259334 @default.
- W2809125364 cites W2008441891 @default.
- W2809125364 cites W2012453729 @default.
- W2809125364 cites W2013163706 @default.
- W2809125364 cites W2013846239 @default.
- W2809125364 cites W2014787267 @default.
- W2809125364 cites W2016091352 @default.
- W2809125364 cites W2016600360 @default.
- W2809125364 cites W2018017154 @default.
- W2809125364 cites W2019279972 @default.
- W2809125364 cites W2022853768 @default.
- W2809125364 cites W2023166679 @default.
- W2809125364 cites W2024628274 @default.
- W2809125364 cites W2026858070 @default.
- W2809125364 cites W2027448097 @default.
- W2809125364 cites W2027460468 @default.
- W2809125364 cites W2027873015 @default.
- W2809125364 cites W2028104082 @default.
- W2809125364 cites W2031754719 @default.
- W2809125364 cites W2031964319 @default.
- W2809125364 cites W2032514134 @default.
- W2809125364 cites W2034021935 @default.
- W2809125364 cites W2035016973 @default.
- W2809125364 cites W2035059547 @default.
- W2809125364 cites W2039684583 @default.
- W2809125364 cites W2042960888 @default.
- W2809125364 cites W2045151039 @default.
- W2809125364 cites W2045470216 @default.
- W2809125364 cites W2047517574 @default.
- W2809125364 cites W2048606094 @default.
- W2809125364 cites W2049061886 @default.
- W2809125364 cites W2050252352 @default.
- W2809125364 cites W2050716704 @default.
- W2809125364 cites W2051025140 @default.
- W2809125364 cites W2052271388 @default.
- W2809125364 cites W2053621737 @default.
- W2809125364 cites W2059478037 @default.
- W2809125364 cites W2060176389 @default.
- W2809125364 cites W2061173467 @default.
- W2809125364 cites W2065498897 @default.
- W2809125364 cites W2065847836 @default.
- W2809125364 cites W2066828509 @default.
- W2809125364 cites W2068966740 @default.
- W2809125364 cites W2069171272 @default.
- W2809125364 cites W2069461792 @default.
- W2809125364 cites W2070792578 @default.
- W2809125364 cites W2071930821 @default.
- W2809125364 cites W2074141888 @default.
- W2809125364 cites W2074608237 @default.
- W2809125364 cites W2074628298 @default.
- W2809125364 cites W2076316598 @default.
- W2809125364 cites W2079204113 @default.
- W2809125364 cites W2080719124 @default.
- W2809125364 cites W2081201102 @default.
- W2809125364 cites W2085027326 @default.
- W2809125364 cites W2085982331 @default.