Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809133070> ?p ?o ?g. }
- W2809133070 endingPage "233" @default.
- W2809133070 startingPage "223" @default.
- W2809133070 abstract "Innovation is increasingly important in the delivery of efficient healthcare; however, the pathways through which medical innovation reach clinical practice are fraught with uncertainty. Further scientific investigation and technological development are normal in medical innovation even when drugs, diagnostics or medical procedures are already adopted. Diffusion studies rarely admit such possibilities as a fundamental element of their conceptual frameworks. This paper explores the diffusion process of an antiretroviral drug (Abacavir) and the introduction of its companion pharmacogenetic test into clinical practice in Italy. This is a landmark case of translational medicine where the principles of pharmacogenetics made an important - applied - contribution to medical innovation shifting the focus away from the diffusion of a complete technology (the drug) towards that of a dynamic technology (Abacavir + developing companion diagnostics). We adopt the historical method to analyse the sequence of events. Key findings show that the diffusion process of a dynamic technology does not fit in the widely accepted S-shaped model for a complete technology. The diffusion phase presents complex interactions amongst the stakeholders involved, each operating on the basis of their own competences within the environment and the regulatory system; the analysis of the diffusion process should proceed through the correct identification of the dynamic technology – the therapy – and cannot be de-coupled from scientific discovery and technological development." @default.
- W2809133070 created "2018-06-29" @default.
- W2809133070 creator A5005017021 @default.
- W2809133070 creator A5009671640 @default.
- W2809133070 creator A5049569770 @default.
- W2809133070 creator A5088755191 @default.
- W2809133070 date "2018-09-01" @default.
- W2809133070 modified "2023-10-18" @default.
- W2809133070 title "Diffusion of complementary evolving pharmaceutical innovations: The case of Abacavir and its pharmacogenetic companion diagnostic in Italy" @default.
- W2809133070 cites W1510986547 @default.
- W2809133070 cites W1572861774 @default.
- W2809133070 cites W1623962738 @default.
- W2809133070 cites W1710922159 @default.
- W2809133070 cites W1966569826 @default.
- W2809133070 cites W1970139648 @default.
- W2809133070 cites W1970873827 @default.
- W2809133070 cites W1972542337 @default.
- W2809133070 cites W1972880268 @default.
- W2809133070 cites W1973270663 @default.
- W2809133070 cites W1983502070 @default.
- W2809133070 cites W1983981789 @default.
- W2809133070 cites W1985923786 @default.
- W2809133070 cites W1994275457 @default.
- W2809133070 cites W1994463508 @default.
- W2809133070 cites W1994897757 @default.
- W2809133070 cites W2016662675 @default.
- W2809133070 cites W2019651488 @default.
- W2809133070 cites W2020069439 @default.
- W2809133070 cites W2025100003 @default.
- W2809133070 cites W2028104603 @default.
- W2809133070 cites W2028331001 @default.
- W2809133070 cites W2035358705 @default.
- W2809133070 cites W2060628494 @default.
- W2809133070 cites W2062044947 @default.
- W2809133070 cites W2067877381 @default.
- W2809133070 cites W2069433056 @default.
- W2809133070 cites W2074203778 @default.
- W2809133070 cites W2076892439 @default.
- W2809133070 cites W2081753990 @default.
- W2809133070 cites W2083085858 @default.
- W2809133070 cites W2086363107 @default.
- W2809133070 cites W2087418073 @default.
- W2809133070 cites W2088052385 @default.
- W2809133070 cites W2089378839 @default.
- W2809133070 cites W2094056187 @default.
- W2809133070 cites W2103811640 @default.
- W2809133070 cites W2112182958 @default.
- W2809133070 cites W2125399507 @default.
- W2809133070 cites W2133995597 @default.
- W2809133070 cites W2140055542 @default.
- W2809133070 cites W2145890930 @default.
- W2809133070 cites W2151419166 @default.
- W2809133070 cites W2161967912 @default.
- W2809133070 cites W2162935528 @default.
- W2809133070 cites W2166550586 @default.
- W2809133070 cites W2168190331 @default.
- W2809133070 cites W2232604650 @default.
- W2809133070 cites W2238552371 @default.
- W2809133070 cites W2286583292 @default.
- W2809133070 cites W2513407075 @default.
- W2809133070 cites W2797105966 @default.
- W2809133070 cites W3121550279 @default.
- W2809133070 cites W3124133074 @default.
- W2809133070 cites W4233264389 @default.
- W2809133070 cites W4248881354 @default.
- W2809133070 cites W4253543067 @default.
- W2809133070 cites W4297958010 @default.
- W2809133070 doi "https://doi.org/10.1016/j.techfore.2018.06.014" @default.
- W2809133070 hasPublicationYear "2018" @default.
- W2809133070 type Work @default.
- W2809133070 sameAs 2809133070 @default.
- W2809133070 citedByCount "3" @default.
- W2809133070 countsByYear W28091330702019 @default.
- W2809133070 countsByYear W28091330702022 @default.
- W2809133070 countsByYear W28091330702023 @default.
- W2809133070 crossrefType "journal-article" @default.
- W2809133070 hasAuthorship W2809133070A5005017021 @default.
- W2809133070 hasAuthorship W2809133070A5009671640 @default.
- W2809133070 hasAuthorship W2809133070A5049569770 @default.
- W2809133070 hasAuthorship W2809133070A5088755191 @default.
- W2809133070 hasBestOaLocation W28091330702 @default.
- W2809133070 hasConcept C111919701 @default.
- W2809133070 hasConcept C112930515 @default.
- W2809133070 hasConcept C116834253 @default.
- W2809133070 hasConcept C142462285 @default.
- W2809133070 hasConcept C160735492 @default.
- W2809133070 hasConcept C17744445 @default.
- W2809133070 hasConcept C199539241 @default.
- W2809133070 hasConcept C21333345 @default.
- W2809133070 hasConcept C2779465607 @default.
- W2809133070 hasConcept C2993143319 @default.
- W2809133070 hasConcept C3013748606 @default.
- W2809133070 hasConcept C41008148 @default.
- W2809133070 hasConcept C512399662 @default.
- W2809133070 hasConcept C59822182 @default.
- W2809133070 hasConcept C71924100 @default.
- W2809133070 hasConcept C86803240 @default.
- W2809133070 hasConcept C98045186 @default.