FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809209936> ?p ?o ?g. }

• W2809209936 endingPage "e11219" @default.
• W2809209936 startingPage "e11219" @default.
• W2809209936 abstract "Because the epidemiology of Clostridium difficile infection (CDI) is region-specific, the present study was undertaken to examine the epidemiology of C difficile outbreaks in Beijing, China. Eighty nonduplicate isolates were collected from March, 2016 to December, 2016. The molecular type and phylogenetic analysis were evaluated by multilocus sequence typing (MLST). The minimum inhibitory concentrations (MICs) for 11 antibiotics and the resistance mechanisms were investigated. Sixty-five toxigenic strains (81.25%), including 22 tcdA-B+CDT- strains (27.5%) and 43 tcdA+B+CDT- strains (53.75%), and also 15 nontoxigenic strains (tcdA-B-CDT-; 18.75%) were detected. MLST identified 21 different sequence types (STs), including 2 novel types (ST409 and ST416). All isolates were susceptible to metronidazole, vancomycin, fidaxomicin, piperacillin/tazobactam, and meropenem, and all were effectively inhibited by emodin (MICs 4–8 μg/mL). The resistance rates to rifaximin, ceftriaxone, clindamycin, erythromycin, and ciprofloxacin were 8.75%, 51.25%, 96.25%, 81.25%, and 96.25%, respectively; 81.25% (65/80) of isolates were multidrug-resistant. Amino acid mutations in GyrA and/or GyrB conferred quinolone resistance. One novel amino acid substitution, F86Y in GyrA, was found in 1 CIP-intermediate strain. The erm(B) gene played a key role in mediating macrolide-lincosamide-streptogramin B (MLSB) resistance. Erm(G) was also found in erm(B)-negative strains that were resistant to both erythromycin and clindamycin. RpoB mutations were associated with rifampin resistance, and 2 new amino mutations were identified in 1 intermediate strain (E573A and E603N). Regional diversity and gene heterogeneity exist in both the ST type and resistant patterns of clinical C difficile isolates in Northern China." @default.
• W2809209936 created "2018-06-29" @default.
• W2809209936 creator A5009099362 @default.
• W2809209936 creator A5037294989 @default.
• W2809209936 creator A5082767963 @default.
• W2809209936 creator A5084083030 @default.
• W2809209936 date "2018-06-01" @default.
• W2809209936 modified "2023-09-26" @default.
• W2809209936 title "Molecular epidemiology and antimicrobial susceptibility of human Clostridium difficile isolates from a single institution in Northern China" @default.
• W2809209936 cites W1685880048 @default.
• W2809209936 cites W1723563490 @default.
• W2809209936 cites W1854083360 @default.
• W2809209936 cites W1905209719 @default.
• W2809209936 cites W1958130321 @default.
• W2809209936 cites W1967996945 @default.
• W2809209936 cites W1983171730 @default.
• W2809209936 cites W1998653042 @default.
• W2809209936 cites W2003497105 @default.
• W2809209936 cites W2006446060 @default.
• W2809209936 cites W2007890464 @default.
• W2809209936 cites W2024026489 @default.
• W2809209936 cites W2059278858 @default.
• W2809209936 cites W2077695558 @default.
• W2809209936 cites W2084475449 @default.
• W2809209936 cites W2086038885 @default.
• W2809209936 cites W2099823842 @default.
• W2809209936 cites W2100344755 @default.
• W2809209936 cites W2100695104 @default.
• W2809209936 cites W2104171041 @default.
• W2809209936 cites W2104491546 @default.
• W2809209936 cites W2106831385 @default.
• W2809209936 cites W2111990189 @default.
• W2809209936 cites W2113556993 @default.
• W2809209936 cites W2127067932 @default.
• W2809209936 cites W2127424257 @default.
• W2809209936 cites W2129216572 @default.
• W2809209936 cites W2132243859 @default.
• W2809209936 cites W2133076450 @default.
• W2809209936 cites W2135913675 @default.
• W2809209936 cites W2140533633 @default.
• W2809209936 cites W2142113823 @default.
• W2809209936 cites W2148890593 @default.
• W2809209936 cites W2155780941 @default.
• W2809209936 cites W2158143521 @default.
• W2809209936 cites W2169794659 @default.
• W2809209936 cites W2171121258 @default.
• W2809209936 cites W2296278790 @default.
• W2809209936 cites W2303104457 @default.
• W2809209936 cites W2311203695 @default.
• W2809209936 cites W2399278318 @default.
• W2809209936 cites W2529864906 @default.
• W2809209936 cites W2566975142 @default.
• W2809209936 cites W2570844395 @default.
• W2809209936 cites W2589006182 @default.
• W2809209936 cites W2591247874 @default.
• W2809209936 cites W2599046258 @default.
• W2809209936 cites W2610277958 @default.
• W2809209936 cites W2725607968 @default.
• W2809209936 cites W2771610202 @default.
• W2809209936 cites W4379533413 @default.
• W2809209936 doi "https://doi.org/10.1097/md.0000000000011219" @default.
• W2809209936 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6023650" @default.
• W2809209936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29924052" @default.
• W2809209936 hasPublicationYear "2018" @default.
• W2809209936 type Work @default.
• W2809209936 sameAs 2809209936 @default.
• W2809209936 citedByCount "16" @default.
• W2809209936 countsByYear W28092099362018 @default.
• W2809209936 countsByYear W28092099362019 @default.
• W2809209936 countsByYear W28092099362020 @default.
• W2809209936 countsByYear W28092099362021 @default.
• W2809209936 countsByYear W28092099362022 @default.
• W2809209936 countsByYear W28092099362023 @default.
• W2809209936 crossrefType "journal-article" @default.
• W2809209936 hasAuthorship W2809209936A5009099362 @default.
• W2809209936 hasAuthorship W2809209936A5037294989 @default.
• W2809209936 hasAuthorship W2809209936A5082767963 @default.
• W2809209936 hasAuthorship W2809209936A5084083030 @default.
• W2809209936 hasBestOaLocation W28092099361 @default.
• W2809209936 hasConcept C104317684 @default.
• W2809209936 hasConcept C135763542 @default.
• W2809209936 hasConcept C159047783 @default.
• W2809209936 hasConcept C2777458120 @default.
• W2809209936 hasConcept C2777637488 @default.
• W2809209936 hasConcept C2778193466 @default.
• W2809209936 hasConcept C2779375183 @default.
• W2809209936 hasConcept C2780206985 @default.
• W2809209936 hasConcept C2994496256 @default.
• W2809209936 hasConcept C501593827 @default.
• W2809209936 hasConcept C523546767 @default.
• W2809209936 hasConcept C54355233 @default.
• W2809209936 hasConcept C71924100 @default.
• W2809209936 hasConcept C77434933 @default.
• W2809209936 hasConcept C86803240 @default.
• W2809209936 hasConcept C89423630 @default.
• W2809209936 hasConcept C94665300 @default.
• W2809209936 hasConcept C97669555 @default.
• W2809209936 hasConceptScore W2809209936C104317684 @default.

• next