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- W2809368035 abstract "Several studies have investigated the impact of IL1A 4-bp insertion/deletion polymorphism (rs3783553) on several human cancers, but the findings are still inconsistent and inconclusive. So, the present meta-analysis was designed to inspect the impact of IL1A 4-bp insertion/deletion and risk of cancer. Eligible studies (published before March 2018) were identified in PubMed, Web of Science, Scopus, and Google scholar databases. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using either a fixed or random-effects models to quantitatively estimate the association. The findings showed that IL1A 4-bp I/D polymorphism significantly associated with the risk of cancer in codominant, dominant, recessive, and allele models. Stratified analysis revealed significant association between that 4-bp I/D polymorphism of IL1A and risk of prostate cancer, cervical cancer, and gynecological cancer. But, this variant was not associated with the risk of hepatocellular carcinoma and gastrointestinal cancer." @default.
- W2809368035 created "2018-06-29" @default.
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- W2809368035 date "2018-09-01" @default.
- W2809368035 modified "2023-09-24" @default.
- W2809368035 title "An updated meta-analysis on the association between 4-bp insertion/deletion (rs3783553) polymorphism within the 3`UTR of IL1A and the risk of cancer" @default.
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- W2809368035 doi "https://doi.org/10.1016/j.genrep.2018.06.006" @default.
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