FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809397712> ?p ?o ?g. }

• W2809397712 endingPage "604" @default.
• W2809397712 startingPage "600" @default.
• W2809397712 abstract "Malignancy is accompanied by changes in the metabolism of both cells and the organism1,2. Pancreatic ductal adenocarcinoma (PDAC) is associated with wasting of peripheral tissues, a metabolic syndrome that lowers quality of life and has been proposed to decrease survival of patients with cancer3,4. Tissue wasting is a multifactorial disease and targeting specific circulating factors to reverse this syndrome has been mostly ineffective in the clinic5,6. Here we show that loss of both adipose and muscle tissue occurs early in the development of pancreatic cancer. Using mouse models of PDAC, we show that tumour growth in the pancreas but not in other sites leads to adipose tissue wasting, suggesting that tumour growth within the pancreatic environment contributes to this wasting phenotype. We find that decreased exocrine pancreatic function is a driver of adipose tissue loss and that replacement of pancreatic enzymes attenuates PDAC-associated wasting of peripheral tissues. Paradoxically, reversal of adipose tissue loss impairs survival in mice with PDAC. When analysing patients with PDAC, we find that depletion of adipose and skeletal muscle tissues at the time of diagnosis is common, but is not associated with worse survival. Taken together, these results provide an explanation for wasting of adipose tissue in early PDAC and suggest that early loss of peripheral tissue associated with pancreatic cancer may not impair survival." @default.
• W2809397712 created "2018-06-29" @default.
• W2809397712 creator A5006842434 @default.
• W2809397712 creator A5007639788 @default.
• W2809397712 creator A5008180849 @default.
• W2809397712 creator A5009113067 @default.
• W2809397712 creator A5017814971 @default.
• W2809397712 creator A5017947396 @default.
• W2809397712 creator A5019690020 @default.
• W2809397712 creator A5022285016 @default.
• W2809397712 creator A5024598961 @default.
• W2809397712 creator A5028547202 @default.
• W2809397712 creator A5029672982 @default.
• W2809397712 creator A5030750875 @default.
• W2809397712 creator A5031717380 @default.
• W2809397712 creator A5045483608 @default.
• W2809397712 creator A5047496278 @default.
• W2809397712 creator A5048782070 @default.
• W2809397712 creator A5052652125 @default.
• W2809397712 creator A5057221073 @default.
• W2809397712 creator A5057349628 @default.
• W2809397712 creator A5064406116 @default.
• W2809397712 creator A5064728099 @default.
• W2809397712 creator A5065098287 @default.
• W2809397712 creator A5067779580 @default.
• W2809397712 creator A5071185138 @default.
• W2809397712 creator A5075684997 @default.
• W2809397712 creator A5081715298 @default.
• W2809397712 creator A5082729431 @default.
• W2809397712 creator A5085137537 @default.
• W2809397712 creator A5090228463 @default.
• W2809397712 date "2018-06-01" @default.
• W2809397712 modified "2023-10-18" @default.
• W2809397712 title "Altered exocrine function can drive adipose wasting in early pancreatic cancer" @default.
• W2809397712 cites W1898606210 @default.
• W2809397712 cites W1950421495 @default.
• W2809397712 cites W1973767788 @default.
• W2809397712 cites W1976355418 @default.
• W2809397712 cites W1978048291 @default.
• W2809397712 cites W1996675676 @default.
• W2809397712 cites W1998166655 @default.
• W2809397712 cites W2000417148 @default.
• W2809397712 cites W2025157903 @default.
• W2809397712 cites W2026114478 @default.
• W2809397712 cites W2035894010 @default.
• W2809397712 cites W2042953513 @default.
• W2809397712 cites W2066135299 @default.
• W2809397712 cites W2068008235 @default.
• W2809397712 cites W2069376956 @default.
• W2809397712 cites W2089057393 @default.
• W2809397712 cites W2101398993 @default.
• W2809397712 cites W2104416279 @default.
• W2809397712 cites W2107089530 @default.
• W2809397712 cites W2107328434 @default.
• W2809397712 cites W2118558111 @default.
• W2809397712 cites W2127424726 @default.
• W2809397712 cites W2145280166 @default.
• W2809397712 cites W2159555803 @default.
• W2809397712 cites W2162821812 @default.
• W2809397712 cites W2259134248 @default.
• W2809397712 cites W2290301118 @default.
• W2809397712 cites W2413384708 @default.
• W2809397712 cites W2553667461 @default.
• W2809397712 cites W2590788086 @default.
• W2809397712 cites W2625770229 @default.
• W2809397712 cites W2737050825 @default.
• W2809397712 cites W375187717 @default.
• W2809397712 doi "https://doi.org/10.1038/s41586-018-0235-7" @default.
• W2809397712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6112987" @default.
• W2809397712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29925948" @default.
• W2809397712 hasPublicationYear "2018" @default.
• W2809397712 type Work @default.
• W2809397712 sameAs 2809397712 @default.
• W2809397712 citedByCount "104" @default.
• W2809397712 countsByYear W28093977122018 @default.
• W2809397712 countsByYear W28093977122019 @default.
• W2809397712 countsByYear W28093977122020 @default.
• W2809397712 countsByYear W28093977122021 @default.
• W2809397712 countsByYear W28093977122022 @default.
• W2809397712 countsByYear W28093977122023 @default.
• W2809397712 crossrefType "journal-article" @default.
• W2809397712 hasAuthorship W2809397712A5006842434 @default.
• W2809397712 hasAuthorship W2809397712A5007639788 @default.
• W2809397712 hasAuthorship W2809397712A5008180849 @default.
• W2809397712 hasAuthorship W2809397712A5009113067 @default.
• W2809397712 hasAuthorship W2809397712A5017814971 @default.
• W2809397712 hasAuthorship W2809397712A5017947396 @default.
• W2809397712 hasAuthorship W2809397712A5019690020 @default.
• W2809397712 hasAuthorship W2809397712A5022285016 @default.
• W2809397712 hasAuthorship W2809397712A5024598961 @default.
• W2809397712 hasAuthorship W2809397712A5028547202 @default.
• W2809397712 hasAuthorship W2809397712A5029672982 @default.
• W2809397712 hasAuthorship W2809397712A5030750875 @default.
• W2809397712 hasAuthorship W2809397712A5031717380 @default.
• W2809397712 hasAuthorship W2809397712A5045483608 @default.
• W2809397712 hasAuthorship W2809397712A5047496278 @default.
• W2809397712 hasAuthorship W2809397712A5048782070 @default.
• W2809397712 hasAuthorship W2809397712A5052652125 @default.

• next