FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809405586> ?p ?o ?g. }

• W2809405586 abstract "The management of patients with triple‑negative breast cancer is challenging due to the lack of effective therapeutic options, aggressive behavior and relatively poor prognosis. Xi Huang pills (XHP) are a well‑known traditional Chinese medicine that demonstrate anticancer activities. The aim of the present study was to investigate the antitumor effects of XHP on MDA‑MB‑231 cells in vitro and in vivo, and its potential underlying molecular mechanisms. In the present study, an MTT assay was used to evaluate the antiproliferative activity of XHP on MDA‑MB‑231 cells. In order to investigate the effects further, cell cycle distribution, apoptosis and mitochondrial membrane potential assays were performed, as well as western blot analyses. In addition, a tumor xenograft model was employed to investigate the effects of XHP in vivo. The results of the MTT assay demonstrated that the viability of MDA‑MB‑231 cells was markedly inhibited by XHP in a dose‑ and time‑dependent manner. The inhibitory effect of XHP on the viability of MDA‑MB‑231 cells was greater when compared with MCF‑10A cells. An increase in apoptosis and loss of mitochondrial membrane potential was observed following 4, 8 and 12 mg/ml XHP treatment of MDA‑MB‑231 cells. The protein expression levels of cleaved caspase‑3 were increased by 1.62‑, 2.13‑ and 2.19‑fold, respectively, when compared with the untreated controls, whereas no effects on the expression of B‑cell lymphoma 2 (Bcl‑2) or Bcl‑2‑associated X protein (Bax) were observed. The results of the cell cycle distribution assay analysis demonstrated that XHP treatment arrested cells at the G2/M phase. In addition, XHP treatment decreased the expression of cyclin A and increased the expression of p21Cip1. In vivo experiments revealed that XHP inhibited the growth of MDA‑MB‑231 xenograft tumors without body weight loss, and demonstrated similar effects on the protein expression levels of cleaved caspase 3, cyclin A and p21Cip1 as observed in vitro. In conclusion, the viability of MDA‑MB‑231 cells was inhibited by XHP in a dose‑dependent, time‑dependent and cell‑selective manner in vitro, and the potential underlying mechanisms may involve apoptosis and cell cycle arrest at the G2/M phase. XHP may induce apoptosis in MDA‑MB‑231 cells via the intrinsic pathway, which does not involve the Bcl‑2/Bax ratio. G2/M phase arrest may have been due to the integrated action of decreased cyclin A expression and increased p21Cip1 expression. In addition, XHP inhibited the growth of xenograft tumors in the absence of body weight loss in vivo." @default.
• W2809405586 created "2018-06-29" @default.
• W2809405586 creator A5002331567 @default.
• W2809405586 creator A5007462313 @default.
• W2809405586 creator A5021664676 @default.
• W2809405586 creator A5032715719 @default.
• W2809405586 creator A5050465730 @default.
• W2809405586 creator A5056495676 @default.
• W2809405586 creator A5063528206 @default.
• W2809405586 creator A5083729859 @default.
• W2809405586 date "2018-06-21" @default.
• W2809405586 modified "2023-10-12" @default.
• W2809405586 title "Antitumor effects of Xi Huang pills on MDA‑MB‑231 cells in�vitro and in�vivo" @default.
• W2809405586 cites W1519042167 @default.
• W2809405586 cites W1551881307 @default.
• W2809405586 cites W1976886432 @default.
• W2809405586 cites W1985459298 @default.
• W2809405586 cites W1987337616 @default.
• W2809405586 cites W1995070503 @default.
• W2809405586 cites W2001110303 @default.
• W2809405586 cites W2009183786 @default.
• W2809405586 cites W2014613601 @default.
• W2809405586 cites W2032007742 @default.
• W2809405586 cites W2054880957 @default.
• W2809405586 cites W2071632100 @default.
• W2809405586 cites W2108319118 @default.
• W2809405586 cites W2120304525 @default.
• W2809405586 cites W2121619780 @default.
• W2809405586 cites W2135662322 @default.
• W2809405586 cites W2137495186 @default.
• W2809405586 cites W2151501496 @default.
• W2809405586 cites W2158025958 @default.
• W2809405586 cites W2524089703 @default.
• W2809405586 cites W2601428550 @default.
• W2809405586 cites W2737370020 @default.
• W2809405586 cites W2789904435 @default.
• W2809405586 doi "https://doi.org/10.3892/mmr.2018.9203" @default.
• W2809405586 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6072179" @default.
• W2809405586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29956784" @default.
• W2809405586 hasPublicationYear "2018" @default.
• W2809405586 type Work @default.
• W2809405586 sameAs 2809405586 @default.
• W2809405586 citedByCount "1" @default.
• W2809405586 countsByYear W28094055862022 @default.
• W2809405586 crossrefType "journal-article" @default.
• W2809405586 hasAuthorship W2809405586A5002331567 @default.
• W2809405586 hasAuthorship W2809405586A5007462313 @default.
• W2809405586 hasAuthorship W2809405586A5021664676 @default.
• W2809405586 hasAuthorship W2809405586A5032715719 @default.
• W2809405586 hasAuthorship W2809405586A5050465730 @default.
• W2809405586 hasAuthorship W2809405586A5056495676 @default.
• W2809405586 hasAuthorship W2809405586A5063528206 @default.
• W2809405586 hasAuthorship W2809405586A5083729859 @default.
• W2809405586 hasBestOaLocation W28094055861 @default.
• W2809405586 hasConcept C104317684 @default.
• W2809405586 hasConcept C1491633281 @default.
• W2809405586 hasConcept C150903083 @default.
• W2809405586 hasConcept C153911025 @default.
• W2809405586 hasConcept C185592680 @default.
• W2809405586 hasConcept C190283241 @default.
• W2809405586 hasConcept C202751555 @default.
• W2809405586 hasConcept C207001950 @default.
• W2809405586 hasConcept C2776415932 @default.
• W2809405586 hasConcept C2780783641 @default.
• W2809405586 hasConcept C2781018059 @default.
• W2809405586 hasConcept C29537977 @default.
• W2809405586 hasConcept C502942594 @default.
• W2809405586 hasConcept C53227056 @default.
• W2809405586 hasConcept C55493867 @default.
• W2809405586 hasConcept C67082663 @default.
• W2809405586 hasConcept C86803240 @default.
• W2809405586 hasConcept C98274493 @default.
• W2809405586 hasConceptScore W2809405586C104317684 @default.
• W2809405586 hasConceptScore W2809405586C1491633281 @default.
• W2809405586 hasConceptScore W2809405586C150903083 @default.
• W2809405586 hasConceptScore W2809405586C153911025 @default.
• W2809405586 hasConceptScore W2809405586C185592680 @default.
• W2809405586 hasConceptScore W2809405586C190283241 @default.
• W2809405586 hasConceptScore W2809405586C202751555 @default.
• W2809405586 hasConceptScore W2809405586C207001950 @default.
• W2809405586 hasConceptScore W2809405586C2776415932 @default.
• W2809405586 hasConceptScore W2809405586C2780783641 @default.
• W2809405586 hasConceptScore W2809405586C2781018059 @default.
• W2809405586 hasConceptScore W2809405586C29537977 @default.
• W2809405586 hasConceptScore W2809405586C502942594 @default.
• W2809405586 hasConceptScore W2809405586C53227056 @default.
• W2809405586 hasConceptScore W2809405586C55493867 @default.
• W2809405586 hasConceptScore W2809405586C67082663 @default.
• W2809405586 hasConceptScore W2809405586C86803240 @default.
• W2809405586 hasConceptScore W2809405586C98274493 @default.
• W2809405586 hasLocation W28094055861 @default.
• W2809405586 hasLocation W28094055862 @default.
• W2809405586 hasLocation W28094055863 @default.
• W2809405586 hasLocation W28094055864 @default.
• W2809405586 hasOpenAccess W2809405586 @default.
• W2809405586 hasPrimaryLocation W28094055861 @default.
• W2809405586 hasRelatedWork W2048146059 @default.
• W2809405586 hasRelatedWork W2080074638 @default.
• W2809405586 hasRelatedWork W2080111928 @default.
• W2809405586 hasRelatedWork W2094452529 @default.

• next