Matches in SemOpenAlex for { <https://semopenalex.org/work/W2809429856> ?p ?o ?g. }
- W2809429856 endingPage "1804" @default.
- W2809429856 startingPage "1804" @default.
- W2809429856 abstract "Thyroid hormones (THs) influence multiple processes in the developing and adult central nervous system, and their local availability needs to be maintained at levels that are tailored to the requirements of their biological targets. The local complement of TH transporters, deiodinase enzymes, and receptors is critical to ensure specific levels of TH action in neural cells. The type 3 iodothyronine deiodinase (DIO3) inactivates THs and is highly present in the developing and adult brain, where it limits their availability and action. DIO3 deficiency in mice results in a host of neurodevelopmental and behavioral abnormalities, demonstrating the deleterious effects of TH excess, and revealing the critical role of DIO3 in the regulation of TH action in the brain. The fact the Dio3 is an imprinted gene and that its allelic expression pattern varies across brain regions and during development introduces an additional level of control to deliver specific levels of hormone action in the central nervous system (CNS). The sensitive epigenetic nature of the mechanisms controlling the genomic imprinting of Dio3 renders brain TH action particularly susceptible to disruption due to exogenous treatments and environmental exposures, with potential implications for the etiology of human neurodevelopmental disorders." @default.
- W2809429856 created "2018-06-29" @default.
- W2809429856 creator A5025755871 @default.
- W2809429856 creator A5030192169 @default.
- W2809429856 date "2018-06-19" @default.
- W2809429856 modified "2023-09-30" @default.
- W2809429856 title "The Type 3 Deiodinase: Epigenetic Control of Brain Thyroid Hormone Action and Neurological Function" @default.
- W2809429856 cites W101501341 @default.
- W2809429856 cites W1481762530 @default.
- W2809429856 cites W1496670813 @default.
- W2809429856 cites W1548473231 @default.
- W2809429856 cites W1600512531 @default.
- W2809429856 cites W1607877556 @default.
- W2809429856 cites W1821797507 @default.
- W2809429856 cites W1874120222 @default.
- W2809429856 cites W1964248550 @default.
- W2809429856 cites W1964827435 @default.
- W2809429856 cites W1965462646 @default.
- W2809429856 cites W1965536495 @default.
- W2809429856 cites W1967607802 @default.
- W2809429856 cites W1967983465 @default.
- W2809429856 cites W1968011921 @default.
- W2809429856 cites W1968724289 @default.
- W2809429856 cites W1968878341 @default.
- W2809429856 cites W1971647523 @default.
- W2809429856 cites W1971708895 @default.
- W2809429856 cites W1972302047 @default.
- W2809429856 cites W1972447384 @default.
- W2809429856 cites W1972651008 @default.
- W2809429856 cites W1973339596 @default.
- W2809429856 cites W1975513261 @default.
- W2809429856 cites W1976309267 @default.
- W2809429856 cites W1978457136 @default.
- W2809429856 cites W1984748289 @default.
- W2809429856 cites W1985913471 @default.
- W2809429856 cites W1987650981 @default.
- W2809429856 cites W1988405671 @default.
- W2809429856 cites W1990657576 @default.
- W2809429856 cites W1991454487 @default.
- W2809429856 cites W1991581797 @default.
- W2809429856 cites W1993618816 @default.
- W2809429856 cites W1999307118 @default.
- W2809429856 cites W2002151701 @default.
- W2809429856 cites W2002154622 @default.
- W2809429856 cites W2003795436 @default.
- W2809429856 cites W2004704824 @default.
- W2809429856 cites W2006665274 @default.
- W2809429856 cites W2006929999 @default.
- W2809429856 cites W2009940298 @default.
- W2809429856 cites W2010914889 @default.
- W2809429856 cites W2011366445 @default.
- W2809429856 cites W2016175608 @default.
- W2809429856 cites W201842558 @default.
- W2809429856 cites W2018776456 @default.
- W2809429856 cites W2021905453 @default.
- W2809429856 cites W2021911548 @default.
- W2809429856 cites W2023134890 @default.
- W2809429856 cites W2023636464 @default.
- W2809429856 cites W2026234549 @default.
- W2809429856 cites W2027842486 @default.
- W2809429856 cites W2030017268 @default.
- W2809429856 cites W2035087361 @default.
- W2809429856 cites W2036110060 @default.
- W2809429856 cites W2038434389 @default.
- W2809429856 cites W2038964583 @default.
- W2809429856 cites W2043008560 @default.
- W2809429856 cites W2043548753 @default.
- W2809429856 cites W2043882061 @default.
- W2809429856 cites W2045703150 @default.
- W2809429856 cites W2046037386 @default.
- W2809429856 cites W2049813666 @default.
- W2809429856 cites W2054275187 @default.
- W2809429856 cites W2055129041 @default.
- W2809429856 cites W2056069396 @default.
- W2809429856 cites W2058421412 @default.
- W2809429856 cites W2058964935 @default.
- W2809429856 cites W2058980325 @default.
- W2809429856 cites W2063595480 @default.
- W2809429856 cites W2063819447 @default.
- W2809429856 cites W2064133930 @default.
- W2809429856 cites W2065440547 @default.
- W2809429856 cites W2067163627 @default.
- W2809429856 cites W2067678215 @default.
- W2809429856 cites W2069320956 @default.
- W2809429856 cites W2070712357 @default.
- W2809429856 cites W2072073963 @default.
- W2809429856 cites W2077012653 @default.
- W2809429856 cites W2078057245 @default.
- W2809429856 cites W2078731706 @default.
- W2809429856 cites W2082068065 @default.
- W2809429856 cites W2082784596 @default.
- W2809429856 cites W2083609386 @default.
- W2809429856 cites W2083726289 @default.
- W2809429856 cites W2085210440 @default.
- W2809429856 cites W2086029165 @default.
- W2809429856 cites W2094889529 @default.
- W2809429856 cites W2095345459 @default.
- W2809429856 cites W2095734937 @default.