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• W2809441519 abstract "<ns4:p>About 20% of the general population is contact-sensitized to common haptens such as fragrances, preservatives, and metals. Many also develop allergic contact dermatitis (ACD), the clinical manifestation of contact sensitization. ACD represents a common health issue and is also one of the most important occupational diseases. Although this inflammatory skin disease is mediated predominantly by memory T lymphocytes recognizing low-molecular-weight chemicals after skin contact, the innate immune system also plays an important role. Along that line, the presence of irritants may increase the risk of ACD and therefore ACD is often seen in the context of irritant contact dermatitis. In this review article, we discuss recent progress in basic research that has dramatically increased our understanding of the pathomechanisms of ACD and provides a basis for the development of novel diagnostic and therapeutic measures. Current methods for diagnosis as well as treatment options of ACD are also discussed.</ns4:p>" @default.
• W2809441519 created "2018-06-29" @default.
• W2809441519 creator A5002498051 @default.
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• W2809441519 date "2018-06-20" @default.
• W2809441519 modified "2023-10-16" @default.
• W2809441519 title "Recent advances in understanding and managing contact dermatitis" @default.
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• W2809441519 doi "https://doi.org/10.12688/f1000research.13499.1" @default.
• W2809441519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6013761" @default.
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• W2809441519 hasPublicationYear "2018" @default.
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