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- W2809464880 abstract "The major change in thinking about models of analgesia over the last decade or so may be seen as a shift away from the earlier emphasis on a one-way afferent transmission sequence. Analgesia was effected, according to the older models, by a simple blocking of afferent impulses as some level (as achieved by local anaesthesia). Recent models suggest that there are at least two CNS analgesia control systems, each operating via an active mechanism for the inhibition of nociception which includes reciprocal efferent impulses able to respond to input from lower centres by sending control signals which modify their output. One CNS analgesia system has now been quite well described. This opiate analgesia system has proved to be naloxene reversible and seems to be mediated by reciprocal pathways between brain stem structures and the dorsal horn and trigeminal caudalis. This is not likely to be the system responsible for all cases of hypnotic analgesia, since common experience of continued awareness of some elements of a normally painful stimulus, in spite of a freedom of pain, implicates a higher level involvement such as input from the prefrontal cortex." @default.
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- W2809464880 date "1988-01-01" @default.
- W2809464880 modified "2023-09-24" @default.
- W2809464880 title "Hypnotic analgesia and reflex inhibition" @default.
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