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- W2809491661 endingPage "255" @default.
- W2809491661 startingPage "244" @default.
- W2809491661 abstract "Immune dysregulation is a defining feature of myelodysplastic syndromes (MDS). Recently, several studies have further defined the complex role of immune alterations within MDS. Herein, we will summarize some of these findings and discuss the therapeutic strategies currently in development.Immune alterations in MDS are complex, heterogeneous, and intertwined with clonal hematopoiesis and stromal cell dysfunction. Inflammation in MDS proceeds as a vicious cycle, mediated in large part by secreted factors, which induce cell death and activate innate immune signaling. Therapeutic targeting of this variable immune dysregulation has led to modest responses thus far, but incorporation of the growing repertoire of immunotherapy brings new potential for improved outcomes. The immune milieu is variable across the spectrum of MDS subtypes, with a changing balance of inflammatory and suppressive cellular forces from low- to high-risk disease." @default.
- W2809491661 created "2018-06-29" @default.
- W2809491661 creator A5008012217 @default.
- W2809491661 creator A5060502100 @default.
- W2809491661 date "2018-06-22" @default.
- W2809491661 modified "2023-10-13" @default.
- W2809491661 title "Disordered Immune Regulation and its Therapeutic Targeting in Myelodysplastic Syndromes" @default.
- W2809491661 cites W1513711973 @default.
- W2809491661 cites W1558724806 @default.
- W2809491661 cites W1961505479 @default.
- W2809491661 cites W1961693387 @default.
- W2809491661 cites W1965615377 @default.
- W2809491661 cites W1968226137 @default.
- W2809491661 cites W1970343951 @default.
- W2809491661 cites W1972996521 @default.
- W2809491661 cites W1974001500 @default.
- W2809491661 cites W1976477978 @default.
- W2809491661 cites W1983973479 @default.
- W2809491661 cites W1986358260 @default.
- W2809491661 cites W1987694020 @default.
- W2809491661 cites W1988600618 @default.
- W2809491661 cites W1992343552 @default.
- W2809491661 cites W2002062621 @default.
- W2809491661 cites W2003579048 @default.
- W2809491661 cites W2004150448 @default.
- W2809491661 cites W2011804335 @default.
- W2809491661 cites W2016055354 @default.
- W2809491661 cites W2018317651 @default.
- W2809491661 cites W2019932788 @default.
- W2809491661 cites W2020719716 @default.
- W2809491661 cites W2022505130 @default.
- W2809491661 cites W2023052004 @default.
- W2809491661 cites W2027667038 @default.
- W2809491661 cites W2028442715 @default.
- W2809491661 cites W2037910376 @default.
- W2809491661 cites W2055445052 @default.
- W2809491661 cites W2056415390 @default.
- W2809491661 cites W2059825042 @default.
- W2809491661 cites W2067545345 @default.
- W2809491661 cites W2070332120 @default.
- W2809491661 cites W2077217249 @default.
- W2809491661 cites W2081606391 @default.
- W2809491661 cites W2082883544 @default.
- W2809491661 cites W2082919098 @default.
- W2809491661 cites W2083377487 @default.
- W2809491661 cites W2100022718 @default.
- W2809491661 cites W2101234143 @default.
- W2809491661 cites W2108884015 @default.
- W2809491661 cites W2111063688 @default.
- W2809491661 cites W2114106581 @default.
- W2809491661 cites W2117375925 @default.
- W2809491661 cites W2125175295 @default.
- W2809491661 cites W2128877614 @default.
- W2809491661 cites W2131095909 @default.
- W2809491661 cites W2132155262 @default.
- W2809491661 cites W2132327973 @default.
- W2809491661 cites W2138024027 @default.
- W2809491661 cites W2152217218 @default.
- W2809491661 cites W2157155777 @default.
- W2809491661 cites W2162825929 @default.
- W2809491661 cites W2168286467 @default.
- W2809491661 cites W2169900655 @default.
- W2809491661 cites W2178103997 @default.
- W2809491661 cites W2209012767 @default.
- W2809491661 cites W2264802194 @default.
- W2809491661 cites W2274764336 @default.
- W2809491661 cites W2335142737 @default.
- W2809491661 cites W2339658711 @default.
- W2809491661 cites W2340797329 @default.
- W2809491661 cites W2345130661 @default.
- W2809491661 cites W2345674384 @default.
- W2809491661 cites W2407839150 @default.
- W2809491661 cites W2414800588 @default.
- W2809491661 cites W2423491126 @default.
- W2809491661 cites W2473996913 @default.
- W2809491661 cites W2512270264 @default.
- W2809491661 cites W2522867493 @default.
- W2809491661 cites W2530814271 @default.
- W2809491661 cites W2531333005 @default.
- W2809491661 cites W2564955822 @default.
- W2809491661 cites W2565273860 @default.
- W2809491661 cites W2569286686 @default.
- W2809491661 cites W2569838360 @default.
- W2809491661 cites W2577785715 @default.
- W2809491661 cites W2585106732 @default.
- W2809491661 cites W2592575609 @default.
- W2809491661 cites W2594882747 @default.
- W2809491661 cites W2597865830 @default.
- W2809491661 cites W2603369913 @default.
- W2809491661 cites W2613042274 @default.
- W2809491661 cites W2628145035 @default.
- W2809491661 cites W2731791503 @default.
- W2809491661 cites W2733520933 @default.
- W2809491661 cites W2749684771 @default.
- W2809491661 cites W2749902186 @default.
- W2809491661 cites W2752628798 @default.
- W2809491661 cites W2758263899 @default.
- W2809491661 cites W2762453060 @default.